دورية أكاديمية
HMGB1 mediates anemia of inflammation in murine sepsis survivors
| العنوان: | HMGB1 mediates anemia of inflammation in murine sepsis survivors |
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| المؤلفون: | Valdes-Ferrer, S. I., Papoin, J., Dancho, M. E., Olofsson, L. P. S., Li, J., Lipton, J. M., Avancena, P., Yang, H., Zou, Y. R., Chavan, S. S., Volpe, B. T., Rivella, S., Diamond, B., Steinberg, B. M., Blanc, L., Tracey, K. J., +2 additional authors |
| المصدر: | Journal Articles |
| بيانات النشر: | Donald and Barbara Zucker School of Medicine Academic Works |
| سنة النشر: | 2015 |
| المجموعة: | Hofstra Northwell Academic Works (Hofstra Northwell School of Medicine) |
| مصطلحات موضوعية: | Neurology, Surgery |
| الوصف: | Patients surviving sepsis develop anemia but the molecular mechanism is unknown. Here we observed that mice surviving polymicrobial Gram-negative sepsis develop hypochromic, microcytic anemia with reticulocytosis. The bone marrow of sepsis survivors accumulates polychromatophilic and orthochromatic erythroblasts. Compensatory extramedullary erythropoiesis in the spleen is defective during terminal differentiation. Circulating TNF and IL-6 are elevated for five days after the onset of sepsis, and serum HMGB1 levels are increased from day seven until at least day 28. Administration of recombinant HMGB1 to healthy mice mediates anemia with extramedullary erythropoiesis and significantly elevated reticulocyte counts. Moreover, administration of anti-HMGB1 monoclonal antibodies after sepsis significantly ameliorates the development of anemia (hematocrit 48.5+/-9.0% versus 37.4+/-6.1%, p |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://academicworks.medicine.hofstra.edu/publications/1453Test; https://academicworks.medicine.hofstra.edu/context/publications/article/2454/viewcontent/MolMed2015v21p961.pdfTest |
| DOI: | 10.2119/molmed.2015.00243 |
| الإتاحة: | https://doi.org/10.2119/molmed.2015.00243Test https://academicworks.medicine.hofstra.edu/publications/1453Test https://academicworks.medicine.hofstra.edu/context/publications/article/2454/viewcontent/MolMed2015v21p961.pdfTest |
| رقم الانضمام: | edsbas.2CF85308 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2119/molmed.2015.00243 |
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