An Efficient and Practical Process for the Synthesis of Glimepiride
| العنوان: | An Efficient and Practical Process for the Synthesis of Glimepiride |
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| المؤلفون: | Dinesh Kumar Tanwar, Manjinder Singh Gill, Vaghela Ravikumar Surendrabhai |
| المصدر: | Synlett. 28:2495-2498 |
| بيانات النشر: | Georg Thieme Verlag KG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Carbamate, 010405 organic chemistry, medicine.drug_class, Aryl, medicine.medical_treatment, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Sulfonylurea, 0104 chemical sciences, Sulfonamide, chemistry.chemical_compound, Glimepiride, chemistry, medicine, Organic chemistry, Phosgene, medicine.drug |
| الوصف: | A novel and simple approach to the synthesis of glimepiride is reported. It involves the preparation of a carbamate of 3-ethyl-4-methyl-1H-pyrrol-2(5H)-one, followed by its reaction with 4-(2-aminoethyl)benzenesulfonamide to produce the intermediate sulfonamide. This sulfonamide, upon reaction with phenyl (trans-4-methylcyclohexyl)carbamate, gave glimepiride. This process avoids the use of phosgene, isocyanates, or chloroformates. Furthermore, sulfonation of the aryl group was eliminated, rendering the product free of the impurities reported in earlier processes. |
| تدمد: | 1437-2096 0936-5214 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::70db94c79b9f23155c0fc39d08f31440Test https://doi.org/10.1055/s-0036-1590836Test |
| رقم الانضمام: | edsair.doi...........70db94c79b9f23155c0fc39d08f31440 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14372096 09365214 |
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