A consensus-based framework for conducting and reporting osteoarthritis phenotype research
| العنوان: | A consensus-based framework for conducting and reporting osteoarthritis phenotype research |
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| المؤلفون: | Robin Christensen, Elena Losina, Lisa C. Carlesso, Sita M A Bierma-Zeinstra, Jesper Knoop, Amanda E. Nelson, Ana M. Valdes, Martin J. Thomas, M. van der Esch, Kathryn Mills, Richard F. Loeser, V. Byers Kraus, M.P.M. Steultjens, Christopher B. Little, George Peat, Tuhina Neogi, David J. Hunter, W.E. van Spil, Leticia A Deveza, Ali Mobasheri, Nigel K Arden, Anne-Christine Bay-Jensen, Christoph Ladel, Peter Kent, A.-C. Rat |
| المساهمون: | Department of Orthopedic Surgery [Boston], Brigham and Women's Hospital [Boston], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), School of Health and Life Sciences [Glasgow Caledonian University], Glasgow Caledonian University (GCU), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Department of Statistics, Penn State University, University of Pennsylvania [Philadelphia], Urban Vitality, Lectoraat Interdisciplinaire Zorg voor Chronische Gewrichtsaandoeningen, Health Economics and Health Technology Assessment, AMS - Ageing and Morbidity, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, General Practice, Orthopedics and Sports Medicine |
| المصدر: | Arthritis Research and Therapy Arthritis Research and Therapy, BioMed Central, 2020, 22 (1), ⟨10.1186/s13075-020-2143-0⟩ Arthritis research & therapy, 22:54. BioMed Central Ltd. Van Spil, W E, Bierma-Zeinstra, S M A, Deveza, L A, Arden, N K, Bay-Jensen, A C, Kraus, V B, Carlesso, L, Christensen, R, Van Der Esch, M, Kent, P, Knoop, J, Ladel, C, Little, C B, Loeser, R F, Losina, E, Mills, K, Mobasheri, A, Nelson, A E, Neogi, T, Peat, G M, Rat, A C, Steultjens, M, Thomas, M J, Valdes, A M & Hunter, D J 2020, ' A consensus-based framework for conducting and reporting osteoarthritis phenotype research ', Arthritis Research and Therapy, vol. 22, no. 1, 54, pp. 1-7 . https://doi.org/10.1186/s13075-020-2143-0Test Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-7 (2020) Arthritis Research and Therapy, 22(1):54, 1-7. BioMed Central Arthritis Research and Therapy, 22. BioMed Central Ltd. Arthritis Research & Therapy, 22, 54 Arthritis Research & Therapy Van Spil, W E, Bierma-Zeinstra, S M A, Deveza, L A, Arden, N K, Bay-Jensen, A C, Kraus, V B, Carlesso, L, Christensen, R, Van Der Esch, M, Kent, P, Knoop, J, Ladel, C, Little, C B, Loeser, R F, Losina, E, Mills, K, Mobasheri, A, Nelson, A E, Neogi, T, Peat, G M, Rat, A C, Steultjens, M, Thomas, M J, Valdes, A M & Hunter, D J 2020, ' A consensus-based framework for conducting and reporting osteoarthritis phenotype research ', Arthritis Research and Therapy, vol. 22, 54 . https://doi.org/10.1186/s13075-020-2143-0Test |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Research Report, Research design, Biomedical Research, Consensus, lcsh:Diseases of the musculoskeletal system, Knowledge management, Delphi Technique, Framework, Q1, Osteoarthritis, Hip, Consensus (maximum 10), 03 medical and health sciences, 0302 clinical medicine, Outcome Assessment, Health Care, Osteoarthritis, Humans, Statistical analysis, 030212 general & internal medicine, Set (psychology), ComputingMilieux_MISCELLANEOUS, computer.programming_language, 030203 arthritis & rheumatology, Operationalization, business.industry, Osteoarthritis, Knee, R1, Phenotype, Study Characteristics, Phenotypes, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Practice Guidelines as Topic, lcsh:RC925-935, business, Psychology, computer, Delphi, Research Article |
| الوصف: | Background The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research. Methods A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies. Results Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided. Conclusions This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients. |
| وصف الملف: | application/pdf |
| تدمد: | 1478-6362 1478-6354 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8beb6d45c3db422310fa46c7643859Test https://doi.org/10.1186/s13075-020-2143-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da8beb6d45c3db422310fa46c7643859 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14786362 14786354 |
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