المؤلفون: Uliassi, Elisa, Fiorani, Giulia, Krauth-Siegel, R. Luise, Bergamini, Christian, Fato, Romana, BIANCHINI, GIULIA, Carlos Menéndez, J., Molina, Maria Teresa, López-Montero, Eulogio, Falchi, Federico, Cavalli, Andrea, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Moraes, Carolina B., Freitas-Junior, Lucio H., Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

المساهمون: Uliassi, Elisa, Fiorani, Giulia, Krauth-Siegel, R. Luise, Bergamini, Christian, Fato, Romana, Bianchini, Giulia, Carlos Menéndez, J., Molina, Maria Teresa, López-Montero, Eulogio, Falchi, Federico, Cavalli, Andrea, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Moraes, Carolina B., Freitas-Junior, Lucio H., Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

مصطلحات موضوعية: Coumarin, Crassiflorone, Glyceraldehyde-3-phosphate dehydrogenase, Leishmaniasi, Natural product, Quinone, Trypanocidal activity, Trypanosomiasi, Trypanothione reductase, Cell Line, Tumor, Dose-Response Relationship, Drug, Human, Models, Molecular, Molecular Structure, NADH, NADPH Oxidoreductase, Parasitic Sensitivity Test, Structure-Activity Relationship, Trypanocidal Agent, Trypanosoma brucei brucei, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29031061; info:eu-repo/semantics/altIdentifier/wos/WOS:000417962900012; volume:141; firstpage:138; lastpage:148; numberofpages:11; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11380/1153742Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85030853675; http://www.journals.elsevier.com/european-journal-of-medicinal-chemistryTest/

الإتاحة: https://doi.org/10.1016/j.ejmech.2017.10.005Test
http://hdl.handle.net/11380/1153742Test
http://www.journals.elsevier.com/european-journal-of-medicinal-chemistryTest/

المؤلفون: Chacón Vargas, Karla Fabiola, Nogueda Torres, Benjamin, Sánchez Torres, Luvia E., Suarez Contreras, Erick, Villalobos Rocha, Juan Carlos, Torres Martinez, Yuridia, Lara Ramirez, Edgar E., Krauth Siegel, R. Luise, Monge, Antonio, Rivera, Gildardo, FIORANI, GIULIA, BOLOGNESI, MARIA LAURA

المساهمون: Chacón-Vargas, Karla Fabiola, Nogueda-Torres, Benjamin, Sánchez-Torres, Luvia E., Suarez-Contreras, Erick, Villalobos-Rocha, Juan Carlo, Torres-Martinez, Yuridia, Lara-Ramirez, Edgar E., Fiorani, Giulia, Krauth-Siegel, R Luise, Bolognesi, Maria Laura, Monge, Antonio, Rivera, Gildardo

مصطلحات موضوعية: Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide, Trypanosoma cruzi, Trypanothione reductase inhibitor, Binding Site, Inhibitory Concentration 50, Molecular Conformation, Molecular Docking Simulation, Molecular Dynamics Simulation, NADH, NADPH Oxidoreductase, Parasitic Sensitivity Test, Protein Binding, Quinoxaline, Structure-Activity Relationship, Trypanocidal Agent, Medicine (all), Organic Chemistry

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28157150; info:eu-repo/semantics/altIdentifier/wos/WOS:000395552400034; volume:22; issue:2; firstpage:1; lastpage:18; numberofpages:18; journal:MOLECULES; http://hdl.handle.net/11585/588434Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85014012878; http://www.mdpi.com/1420-3049/22/2/220/pdfTest

الإتاحة: https://doi.org/10.3390/molecules22020220Test
http://hdl.handle.net/11585/588434Test
http://www.mdpi.com/1420-3049/22/2/220/pdfTest

المؤلفون: Annika Wagner, R. Luise Krauth-Siegel, Silvana Grasso, Khawla Chouchene, Jiri Gut, Ute A. Hellmich, Kathrin Ulrich, Peter Wich, Philip J. Rosenthal, Roberta Ettari, Maria Zappalà, Giorgio Amendola, Tanja Schirmeister, Santo Previti, Sandro Cosconati, Ira Schmid

المساهمون: Previti, Santo, Ettari, Roberta, Cosconati, Sandro, Amendola, Giorgio, Chouchene, Khawla, Wagner, Annika, Hellmich, Ute A., Ulrich, Kathrin, Krauth siegel, R. Luise, Wich, Peter R., Schmid, Ira, Schirmeister, Tanja, Gut, Jiri, Rosenthal, Philip J., Grasso, Silvana, Zappalã , Maria

المصدر: Journal of Medicinal Chemistry. 60:6911-6923

مصطلحات موضوعية: 0301 basic medicine, Cathepsin L, Antimalarial, Peptide, HeLa Cell, 01 natural sciences, Cysteine Proteinase Inhibitor, Dipeptide, Drug Discovery, Peptide sequence, chemistry.chemical_classification, Trypanocidal Agent, biology, Neglected Diseases, Stereoisomerism, Dipeptides, Trypanocidal Agents, MAJOR CYSTEINE PROTEASE, PLASMODIUM-FALCIPARUM, TRYPANOSOMA-BRUCEI, CONFORMATIONAL-ANALYSIS, BIOLOGICAL EVALUATION, HIGHLY POTENT, VINYL-ESTER, INHIBITORS, PEPTIDOMIMETICS, SUBSTRATE, Molecular Docking Simulation, Cysteine Endopeptidases, Biochemistry, Molecular Medicine, Human, Proteases, Neglected Disease, Stereochemistry, Phenylalanine, Plasmodium falciparum, Trypanosoma brucei brucei, Cysteine Proteinase Inhibitors, Molecular Dynamics Simulation, Trypanosoma brucei, Antimalarials, Structure-Activity Relationship, 03 medical and health sciences, parasitic diseases, Humans, Structure–activity relationship, 010405 organic chemistry, Drug Discovery3003 Pharmaceutical Science, Hydrogen Bonding, Trypanosoma brucei rhodesiense, biology.organism_classification, Malaria, 0104 chemical sciences, Trypanosomiasis, African, 030104 developmental biology, chemistry, Carbamate, Carbamates, Cysteine Endopeptidase, HeLa Cells, Cysteine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d9b095592e567456d44767db643e0bTest
https://doi.org/10.1021/acs.jmedchem.7b00405Test

المؤلفون: Bernhard Wünsch, R. Luise Krauth-Siegel, Marcel Kaiser, Valquíria A. P. Jabor, Thomas J. Schmidt, Kirstin Lehmkuhl, Frederik Börgel, Maria Cristina Nonato, Dirk Schepmann, Jan-Frederik Uth

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Plasmodium, Erythrocytes, Alkylation, Chemistry Techniques, Synthetic, 01 natural sciences, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Biotransformation, Biomimetic Materials, Drug Discovery, medicine, Side chain, Animals, Moiety, Benzopyrans, 030304 developmental biology, Biological Products, 0303 health sciences, Natural product, Combinatorial chemistry, 0104 chemical sciences, Benzopyran, Kinetics, 010404 medicinal & biomolecular chemistry, chemistry, Mechanism of action, Molecular Medicine, medicine.symptom, Chirality (chemistry), PRODUTOS NATURAIS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe66ab5f7e7b353b8a514f78b4071c8Test

المؤلفون: R. Luise Krauth-Siegel, Mairin Lenz, Thomas J. Schmidt

المصدر: Molecules
Volume 24
Issue 20
Molecules, Vol 24, Iss 20, p 3737 (2019)

مصطلحات موضوعية: Trypanosoma brucei, Stereochemistry, Trypanosoma cruzi, Trypanothione, Pharmaceutical Science, Sesquiterpene lactone, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, Lactones, Structure-Activity Relationship, lcsh:Organic chemistry, Drug Discovery, parasitic diseases, sesquiterpene lactone, Animals, Humans, NADH, NADPH Oxidoreductases, Physical and Theoretical Chemistry, Enzyme Inhibitors, antitrypanosomal activity, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, irreversible inhibitor, Dithiol, trypanothione reductase, Trypanosoma brucei rhodesiense, biology.organism_classification, 0104 chemical sciences, Enzyme, chemistry, Chemistry (miscellaneous), 4,15-iso-atriplicolide ester, Molecular Medicine, Sesquiterpenes, Cysteine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616615d012ce1b6b2eadd6033fed41b4Test

المؤلفون: August Stich, Ines Schmidt, Elena Katzowitsch, Heike Bruhn, Antje Fuß, Alexandra Miliu, Sarah Göllner, Tanja Schirmeister, Anna Kucharski, R. Luise Krauth-Siegel, Ulrike Holzgrabe

المصدر: Bioorganic & Medicinal Chemistry. 25:4526-4531

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Trypanosoma brucei brucei, Clinical Biochemistry, Pharmaceutical Science, Flavoprotein, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Oxidoreductase, parasitic diseases, Drug Discovery, medicine, Animals, African trypanosomiasis, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Trypanosoma brucei rhodesiense, medicine.disease, biology.organism_classification, Trypanocidal Agents, Cysteine protease, Trypanosomiasis, African, 030104 developmental biology, Tacrine, Antiprotozoal, biology.protein, Molecular Medicine, Protozoa, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4044085813e651531a3dd560959511dTest
https://doi.org/10.1016/j.bmc.2017.06.051Test

المؤلفون: Emil F. Pai, Dora Harangozo, Ondrej Halgas, Raoul De Gasparo, R. Luise Krauth-Siegel, Marcel Kaiser, François Diederich

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany). 25(49)

مصطلحات موضوعية: Glutathione reductase, Trypanosoma brucei brucei, Protozoan Proteins, Trypanosoma brucei, Molecular Dynamics Simulation, 010402 general chemistry, Crystallography, X-Ray, Ligands, 01 natural sciences, Catalysis, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Catalytic Domain, parasitic diseases, medicine, African trypanosomiasis, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, Pathogen, Binding Sites, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, General Chemistry, biology.organism_classification, medicine.disease, In vitro, 0104 chemical sciences, 3. Good health, Biochemistry, Drug Design, biology.protein, Trypanosoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708ff6cfd9aeef404726c2d64ef54fceTest
https://pubmed.ncbi.nlm.nih.gov/31407832Test

المؤلفون: Previti, Santo, Ettari, Roberta, Amendola, Giorgio, Chouchene, Khawla, Wagner, Annika, Hellmich, Ute A., Ulrich, Kathrin, Krauth siegel, R. Luise, Wich, Peter R., Schmid, Ira, Schirmeister, Tanja, Gut, Jiri, Rosenthal, Philip J., Grasso, Silvana, Zappalã , Maria, COSCONATI, Sandro

المساهمون: Previti, Santo, Ettari, Roberta, Cosconati, Sandro, Amendola, Giorgio, Chouchene, Khawla, Wagner, Annika, Hellmich, Ute A., Ulrich, Kathrin, Krauth siegel, R. Luise, Wich, Peter R., Schmid, Ira, Schirmeister, Tanja, Gut, Jiri, Rosenthal, Philip J., Grasso, Silvana, Zappalã , Maria

مصطلحات موضوعية: Antimalarial, Carbamate, Cathepsin L, Cysteine Endopeptidase, Cysteine Proteinase Inhibitor, Dipeptide, HeLa Cell, Human, Hydrogen Bonding, Malaria, Molecular Docking Simulation, Molecular Dynamics Simulation, Neglected Disease, Phenylalanine, Plasmodium falciparum, Stereoisomerism, Structure-Activity Relationship, Trypanocidal Agent, Trypanosoma brucei brucei, Trypanosomiasis, African, Molecular Medicine, Drug Discovery3003 Pharmaceutical Science

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28763614; info:eu-repo/semantics/altIdentifier/wos/WOS:000408598500008; volume:60; issue:16; firstpage:6911; lastpage:6923; numberofpages:13; journal:JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11591/379707Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85028597390; http://pubs.acs.org/jmcTest

الإتاحة: https://doi.org/10.1021/acs.jmedchem.7b00405Test
http://hdl.handle.net/11591/379707Test
http://pubs.acs.org/jmcTest

المؤلفون: Giulia Bianchini, Bernhard Ellinger, Lucio H. Freitas-Junior, Giulia Fiorani, Eulogio López-Montero, Maria Laura Bolognesi, Maria Teresa Molina, Gesa Witt, Elisa Uliassi, R. Luise Krauth-Siegel, Maria Paola Costi, Romana Fato, Christian Bergamini, Federico Falchi, Sheraz Gul, J. Carlos Menéndez, Carolina B. Moraes, Maria Kuzikov, Andrea Cavalli, Chiara Borsari

المساهمون: DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 03 - Scienze chimiche, AREA MIN. 05 - Scienze biologiche, Publica, Uliassi, Elisa, Fiorani, Giulia, Krauth-Siegel, R. Luise, Bergamini, Christian, Fato, Romana, Bianchini, Giulia, Carlos Menéndez, J., Molina, Maria Teresa, López-Montero, Eulogio, Falchi, Federico, Cavalli, Andrea, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Moraes, Carolina B., Freitas-Junior, Lucio H., Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

مصطلحات موضوعية: 0301 basic medicine, Parasitic Sensitivity Test, Models, Molecular, Crassiflorone, Trypanosomiasi, Dehydrogenase, 01 natural sciences, NADPH Oxidoreductases, chemistry.chemical_compound, Parasitic Sensitivity Tests, Coumarins, Models, Drug Discovery, NADH, NADPH Oxidoreductases, Leishmaniasis, Glyceraldehyde 3-phosphate dehydrogenase, Natural products, Tumor, biology, Trypanocidal Agent, Molecular Structure, Quinones, Glyceraldehyde-3-Phosphate Dehydrogenases, General Medicine, Trypanocidal Agents, Biochemistry, Quinone, Glyceraldehyde-3-phosphate dehydrogenase, Diospyros crassiflora, Drug, Human, Leishmaniasi, Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei, Coumarin, Natural product, Cell Line, Dose-Response Relationship, 03 medical and health sciences, Structure-Activity Relationship, Trypanosomiasis, Cell Line, Tumor, Structure–activity relationship, Humans, Trypanocidal agent, Trypanocidal activity, Pharmacology, Dose-Response Relationship, Drug, 010405 organic chemistry, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Molecular, biology.organism_classification, 0104 chemical sciences, 030104 developmental biology, Trypanothione reductase, chemistry, NADH, biology.protein, NADH, NADPH Oxidoreductase

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd27927f3e2d6ad95ba8f890079d66dbTest
http://hdl.handle.net/11585/621363Test

المؤلفون: Alejandro E. Leroux, R. Luise Krauth-Siegel

المصدر: Molecular and biochemical parasitology. 206(1-2)

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma, Trypanothione, Antiprotozoal Agents, Protozoan Proteins, Gene Expression, Biology, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, Amide Synthases, Detoxification, medicine, Animals, Chagas Disease, NADH, NADPH Oxidoreductases, Molecular Targeted Therapy, Sulfhydryl Compounds, Enzyme Inhibitors, Molecular Biology, Leishmaniasis, chemistry.chemical_classification, Leishmania, medicine.disease, biology.organism_classification, High-Throughput Screening Assays, 030104 developmental biology, Enzyme, Trypanosomiasis, African, chemistry, Biochemistry, Parasitology, Oxidation-Reduction, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf5150294bb9e321e4f0921797b4145Test
https://pubmed.ncbi.nlm.nih.gov/26592324Test