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1
المؤلفون: Zhou Zuwen, Yi Chen, Dong-Ze Lin, Yu-Ting Duan, Jiang Lihua, Liu Yanxin, Xingdong Zhao, Yu-xiang Wang, Yi Wang, Xi Zhang, Yiming Sun, Jian Ding, Meiyu Geng, Linghua Meng
المصدر: Acta Pharmacol Sin
مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Mice, Nude, Antineoplastic Agents, mTORC1, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Animals, Humans, Pharmacology (medical), Kinome, Cells, Cultured, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Pharmacology, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, fungi, Neoplasms, Experimental, General Medicine, medicine.disease, Lymphoma, 030104 developmental biology, Apoptosis, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Female, Lymphoma, Large B-Cell, Diffuse, Drug Screening Assays, Antitumor, Idelalisib, Diffuse large B-cell lymphoma
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff493d7fa61a5246d92e48b526e3ac3Test
https://doi.org/10.1038/s41401-021-00644-1Test -
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المؤلفون: Ao Zhang, Chunyong Ding, Yi Wang, Linghua Meng, Wei Guo, Xiaohua Liu, Pu Sun, Chen Shulun
المصدر: European Journal of Medicinal Chemistry. 179:38-55
مصطلحات موضوعية: Male, medicine.medical_treatment, Antineoplastic Agents, Pharmacology, 01 natural sciences, Immune tolerance, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Potency, Moiety, Amines, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Cell Proliferation, 030304 developmental biology, Mice, Inbred BALB C, Oxadiazoles, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, Immunotherapy, Small molecule, Rats, 0104 chemical sciences, HEK293 Cells, Drug Design, Cancer cell, biology.protein, Female, Drug Screening Assays, Antitumor, Antibody
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358dea415ba7e81b4749d7ad154d3a91Test
https://doi.org/10.1016/j.ejmech.2019.06.037Test -
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المؤلفون: Linghua Meng, Mingyue Zheng, Yang Ye, Wei Guo, Chunping Tang, Sheng Yao, Pu Sun, Tianbiao Yang
المصدر: Acta Pharmacologica Sinica
مصطلحات موضوعية: 0301 basic medicine, High-throughput screening, Article, natural product library, law.invention, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Non-competitive inhibition, law, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Pharmacology (medical), indoleamine 2,3-dioxygenase 1 inhibitor, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Cells, Cultured, Pharmacology, chemistry.chemical_classification, Biological Products, Natural product, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, General Medicine, Recombinant Proteins, Tryptophan Oxygenase, High-Throughput Screening Assays, HEK293 Cells, 030104 developmental biology, Enzyme, Biochemistry, Docking (molecular), high-throughput fluorescence-based screening, 030220 oncology & carcinogenesis, Recombinant DNA, Uncompetitive inhibitor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083d65a8a0b2d431068173ed4f16aca6Test
https://doi.org/10.1038/s41401-019-0246-4Test -
4
المؤلفون: Linghua Meng, Guolin Wu, Bao Cheng, Qin Chen, Shengming Ma, Guirong Zhu
المصدر: European Journal of Medicinal Chemistry. 228:113930
مصطلحات موضوعية: Cell cycle checkpoint, Antineoplastic Agents, Microtubules, Polymerization, Mice, Structure-Activity Relationship, Tubulin, In vivo, Microtubule, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, IC50, Cell Proliferation, Pharmacology, Mice, Inbred BALB C, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Biphenyl Compounds, Organic Chemistry, Mammary Neoplasms, Experimental, General Medicine, Drug Resistance, Multiple, Tubulin Modulators, Multiple drug resistance, Drug Resistance, Neoplasm, Cancer cell, Microsome, biology.protein, Cancer research, Female, Drug Screening Assays, Antitumor, Colchicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626bed45ebe09eddee7c7cd72feb33f1Test
https://doi.org/10.1016/j.ejmech.2021.113930Test -
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المؤلفون: Jian Ding, Bo Li, Zhijian Xu, Weiliang Zhu, Xiang Wang, He-Yao Wang, Jianming Zhu, Zhuo Yang, Bin-bin Guo, Linghua Meng, Guimin Wang
المصدر: Acta Pharmacologica Sinica. 38:1059-1068
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Molecular model, Stereochemistry, In vitro toxicology, Dabrafenib, General Medicine, Biology, Molecular Docking Simulation, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Biochemistry, Docking (molecular), 030220 oncology & carcinogenesis, RNA splicing, medicine, Structure–activity relationship, Pharmacology (medical), Vemurafenib, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc50e148fd5cffa4cc823166741392aTest
https://doi.org/10.1038/aps.2016.173Test -
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المؤلفون: Meng Wu, Lihua Qing, Guifang Han, Ziwen Wang, Jian Ding, Xue-ling Liu, Yu-xiang Wang, Linghua Meng, Yuxiu Liu, Qingmin Wang
المصدر: Bioorganicmedicinal chemistry. 27(14)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Mode of action, Molecular Biology, IC50, DNA synthesis, 010405 organic chemistry, Cell growth, Chemistry, Organic Chemistry, Cancer, Biological activity, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cell culture, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ed711a0f4dd3b028afddc487e75335Test
https://pubmed.ncbi.nlm.nih.gov/31171403Test -
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المؤلفون: Yi Wang, Xi Zhang, Linghua Meng, Kun Song, Xiuyan Yang, Ruan Cong, Meng Deng, Jian Zhang
المصدر: Chemical biologydrug designREFERENCES. 94(6)
مصطلحات موضوعية: Pyrimidine, Thienopyridines, Class I Phosphatidylinositol 3-Kinases, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Protein Isoforms, Phosphatidylinositol, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Pharmacology, chemistry.chemical_classification, Binding Sites, 010405 organic chemistry, Kinase, Organic Chemistry, Biological activity, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, Molecular Medicine, Drug Screening Assays, Antitumor, Intracellular, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f75900a7be7a228bb54aa910d129842Test
https://pubmed.ncbi.nlm.nih.gov/30381889Test -
8
المؤلفون: Zhaobing Gao, Jian Ding, Cun Tan, Zhi-Wei Gao, Hao-Yue Xiang, Chunhao Yang, Yanhong Chen, Yi Wang, Yi Chen, Linghua Meng, Yi Su, Xi Zhang, Xiang Wang, Xiaoyan Chen, Bing Xiong
المصدر: European Journal of Medicinal Chemistry. 209:112913
مصطلحات موضوعية: Carbamate, Stereochemistry, Morpholines, medicine.medical_treatment, Alpha (ethology), Angiogenesis Inhibitors, Antineoplastic Agents, 01 natural sciences, Piperazines, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Western blot, Drug Discovery, medicine, Animals, Humans, Pyrroles, Molecular Targeted Therapy, Phosphorylation, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, Pharmacology, Mice, Inbred BALB C, 0303 health sciences, Trifluoromethyl, medicine.diagnostic_test, 010405 organic chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, General Medicine, 0104 chemical sciences, Bioavailability, Molecular Docking Simulation, chemistry, Female, Drug Screening Assays, Antitumor, Proto-Oncogene Proteins c-akt, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7eb13230ba2b34cbb2c3b78295cb8dTest
https://doi.org/10.1016/j.ejmech.2020.112913Test -
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المؤلفون: Yi Wang, Hao-Yue Xiang, Chunhao Yang, Linghua Meng, Jian Ding, Yanhong Chen, Xi Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127194
مصطلحات موضوعية: Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Scaffold hopping, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Ic50 values, Humans, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Triazine, Dose-Response Relationship, Drug, Molecular Structure, Triazines, 010405 organic chemistry, Kinase, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Design synthesis, Drug Design, Molecular Medicine, Drug Screening Assays, Antitumor, Human cancer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8884eadf3a75ec8a551ab7679f9455a4Test
https://doi.org/10.1016/j.bmcl.2020.127194Test -
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المؤلفون: Xi Zhang, Manman Wei, Zilan Song, Xiang Wang, Linghua Meng, Jian Ding, Ao Zhang
المصدر: European journal of medicinal chemistry. 125
مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Chronic lymphocytic leukemia, P70-S6 Kinase 1, Antineoplastic Agents, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Protein kinase B, Protein Kinase Inhibitors, Cell Proliferation, Quinazolinones, Pharmacology, Phosphoinositide 3-kinase, biology, Chemistry, Organic Chemistry, General Medicine, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Molecular Docking Simulation, Leukemia, 030104 developmental biology, Biochemistry, biology.protein, Cancer research, Phosphorylation, Idelalisib
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66b10101ed7238dbbf59db5da693d6cTest
https://pubmed.ncbi.nlm.nih.gov/27846451Test