التفاصيل البيبلوغرافية
العنوان:
Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
المؤلفون:
Fizazi, Karim , Tran, Namphuong , Fein, Luis , Matsubara, Nobuaki , Rodriguez Antolin, Alfredo , Alekseev, Boris Y. , Ãzgã¼roglu, Mustafa , Dingwei, Ye , Feyerabend, Susan , Protheroe, Andrew , De Porre, Peter , Kheoh, Thian , Park, Youn C. , Todd, Mary B. , Chi , Korbenfeld E, Kim N. , Metrebian, S , Kaen, L , Staneloni, E , Batagelj, E , Tan, H , Hovey, E , Woo, H , Frydenberg, M , Chua, W , D’Hondt, L , Evaraert, E , Verschaeve, V , Wynendaele, W , Schrijvers, D , Waltregny, D , Whenham, N , Demey, W , Franke, F , Panhoca, R , Damião, R , Zucca, L , Da Rosa, V , Reis, R , Scalabrini, A , Nahas, W , Girotto, G , Nogueira, A , Gomes, A , Coradazzi, A , Kurteva, G , Siemens, R , Gingerich, J , Fleshner, N , Fradet, Y , Morgan, S , North, S , Saad, F , Shayegan, B , Zalewski, P , Pinochet, R , Orellana, N , Ding, Q , Ye, Z , Xie, L , Du, C , Chen, Z , Huang, Y , Sun, Z , Li, H , Jin, J , Li, C , Wan, B , Tian, Y , Zhou, F , Xie, K , Yao, X , Qiu, M , Zou, Q , Na, Y , Sun, Y , Xue, B , Ma, L , Martinez, C , Salazar, M , Larios, C , Solano, S , Pavlik, I , Brodak, M , Hora, M , Büchler, T , Borre, M , Johansen, J , Mejlholm, I , Poulsen, M , Wittendorf, He , Tammela, T , Vaarala, M , Theodore, C , Staudacher, L , Villers, A , Laplaige, P , Suttman, H , Steuber, T , Natale, S , Jones, R , Tran, A , Mazhar, D , Mills, J , Nyirady, P , Salamon, C , Torzsok, F , Feher, J , Géczi, L , Lakatos, A , Keizman, D , Sella, A , Frank, S , Peer, A , Rosenbaum, E , Berger, R , Mermershtain, W , Carteni, G , Tonini, G , De Giorgi, U , Facchini, G , Berruti, Alfredo , Bracarda, S , Basso, U , Galli, L , Tortora, G , Alietta, M , Fukasawa, S , Suzuki, H , Hasumi, H , Tsuchiya, T , Uemura, H , Kanayama, H , Hashine, K , Sato, F , Matsumoto, H , Oya, M , Lee, Jl , Park, S , Keam, B , Yun, H , Kim, Y , Kang, B , Lee, K , Kim, C , Saad, M , Sundram, M , Calvo, D , Moreno, R , Rodriquez, J , Hernandez, C , van den Berg, H , De La Rosett, J , Van Moorse, R , Hunting, J , Hendriks, M , Kueppers, F , Gilling, P , Beaven, A , Holmes, M , Jassem, J , Oszukowska, E , Niezabitowski, J , Jaxa Larecka, D , Chwalinski, M , Swiniarski, P , Silva, C , Conceicãoa, P , Fraga, A , Mauricio, J , Rodrigues, T , Pinheiro, L , Lima, E , Palma Dos Reis, J , Volovat, C , Jinga, V , Harza, M , Alyasova, A , Budnik, N , Bychkov, Y , Izmaylov, A , Khvorosten, D , Matveev, V , Novsov, A , Vladimirov, V , Tevs, D , Sheveleva, L , Bulanov, A , Semenov, A , Fadeeva, N , Kulikov, E , Emelyanov, S , Karyakin, O , Shirinkin, V , Shkolnik, M , Lykov, A , Skopin, P , Kopyltsov, E , Mincik, I , Mir, O , Kliment, J , Mikurcik, E , Gajdos, M , Milichovsky, I , Malan, J , Bahlmann, J , Moshokoa, E , Madlala, T , Coetzee, L , Ribal, M , Miñana, B , Martinez Breijo, S , Carballido, J , Olmos, D , Requena, M , Morote, J , Damber, Je , Haggman, M , Nyman, C , Ljungberg, B , Bjartell, A , Ozen, H , Beduk, Y , Sozen, S , Cetinkaya, M , Ozyurt, M , Tansug, Z , Mungan, A , Tanidir, Y , Toktas, M , Hotko, E , Stus, V , Lyulko, O , Vinnyk, Y , Shparyk, Y , Sakalo, V , Bondarenko, I , Paramonov, V , Khareba, G , Hodos, V.
المساهمون:
Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, Tampere University, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'oncologie médicale
المصدر:
The New England journal of medicine, Vol. 377, no. 4, p. 352-360 (2017)
بيانات النشر:
Massachusetts Medical Society, 2017.
سنة النشر:
2017
مصطلحات موضوعية:
Adult , Male , medicine.medical_specialty , Prednisolone , Kirurgia, anestesiologia, tehohoito, radiologia - Surgery, anesthesiology, intensive care, radiology , Abiraterone Acetate , 030232 urology & nephrology , Urology , 03 medical and health sciences , Prostate cancer , chemistry.chemical_compound , 0302 clinical medicine , Prednisone , Antineoplastic Combined Chemotherapy Protocols , 80 and over , medicine , Humans , Aged , Aged, 80 and over , Androgen Antagonists , Middle Aged , Neoplasm Metastasis , Prostatic Neoplasms , Steroid 17-alpha-Hydroxylase , Survival Analysis , Medicine (all) , Gynecology , business.industry , Apalutamide , Abiraterone acetate , General Medicine , medicine.disease , Interim analysis , Clinical trial , Darolutamide , chemistry , 030220 oncology & carcinogenesis , business , medicine.drug
الوصف:
Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer. In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group). The two primary end points were overall survival and radiographic progression-free survival. After a median follow-up of 30.4 months at a planned interim analysis (after 406 patients had died), the median overall survival was significantly longer in the abiraterone group than in the placebo group (not reached vs. 34.7 months) (hazard ratio for death, 0.62; 95% confidence interval [CI], 0.51 to 0.76; P
وصف الملف:
fulltext
تدمد:
1533-4406
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1802294eaa5a930bead58e33d28c57b6Test https://doi.org/10.1056/nejmoa1704174Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....1802294eaa5a930bead58e33d28c57b6
قاعدة البيانات:
OpenAIRE
