دورية أكاديمية
Risk factors and outcome of COVID-19 in patients with hematological malignancies
| العنوان: | Risk factors and outcome of COVID-19 in patients with hematological malignancies |
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| المؤلفون: | Piñana, José Luis, Martino, Rodrigo, García-García, Irene, Parody, Rocío, Morales, María Dolores, Benzo, Gonzalo, Gómez-Catalan, Irene, Coll, Rosa, De La Fuente, Ignacio, Luna, Alejandro, Merchán, Beatriz, Chinea, Anabelle, de Miguel, Dunia, Serrano, Ana, Pérez, Carmen, Diaz, Carola, Lopez, José Luis, Jesús Saez, Adolfo, Bailen, Rebeca, Zudaire, Teresa, Martínez, Diana, Jurado, Manuel, Calbacho, María, Vázquez, Lourdes, Garcia-Cadenas, Irene, Fox, Laura, Pimentel, Ana I, Bautista, Guiomar, Nieto, Agustin, Fernandez, Pascual, Vallejo, Juan Carlos, Solano, Carlos, Valero, Marta, Espigado, Ildefonso, Saldaña, Raquel, Sisinni, Luisa, Ribera, Josep Maria, Jimenez, Maria Jose, Trabazo, Maria, Gonzalez-Vicent, Marta, Fernández, Noemí, Talarn, Carme, Montoya, Maria Carmen, Cedillo, Angel, Sureda, Anna |
| المساهمون: | Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana,JL Hematology División, Hospital Universitario y Politécnico La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. Piñana,JL CIBERONC, Instituto Carlos III, Madrid, Spain. Martino,R, Garcia‑Cadenas,I Hematology División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. García-García,I, Luna,A, Chinea,A, Saez,AJ Hematology División, Hospital Ramon y Cajal, Madrid, Spain. Parody,R, Sureda,A Hematology División, Institut Català Oncologia-Hospital Duran i Reynals, Barcelona, Spain. Morales,MD, Merchán,B, de Miguel,D Hematology División, Hospital de Guadalajara, Guadalajara, Spain. Benzo,G Hematology División, Hospital La Princesa, Madrid, Spain. Gómez-Catalan,I, Serrano,A, Montoya,MC Hematology División, Hospital de Albacete, Albacete, Spain. Coll,R Hematology División, Institut Català Oncologia-Hospital Josep Trueta, Girona, Spain. De La Fuente,I, Pérez,C Hematology División, Hospital Clínico de Valladolid, Valladolid, Spain. Diaz,C Hematology División, Hospital Carlos Haya, Malaga, Spain. Lopez, JL Hematology División, Hospital Fundación Jiménez Díaz, Madrid, Spain. Bailen,R Hematology División, Hospital Gregorio Marañon, Madrid, Spain. Zudaire,T Hematology División, Hospital de Navarra, Navarra, Spain. Martínez,D Hematology División, Hospital a Coruña, Coruña, Spain. Jurado,M Hematology División, Hospital Virgen de la Nieves, Granada, Spain. Calbacho,M Hematology División, Hospital 12 de Octubre, Madrid, Spain. Vázquez,L Hematology División, Hospital Universitario de Salamanca, Salamanca, Spain. Fox,L Hematology División, Hospital Vall d`Hebron, Barcelona, Spain. Pimentel,AI Hematology División, Hospital Clínico Universitario Lozano Blesa, IIS Aragon, Zaragoza, Spain. Bautista,G Hematology División, Hospital Puerta de Hierro, Madrid, Spain. Nieto,A Hematology División, Hospital de Vigo, Vigo, Spain. Fernandez,P Hematology División, Hospital General de Alicante, Alicante, Spain. Vallejo,JC Hematology División, Hospital de Donostia, Donostia, Spain. Solano,C Hematology División, Hospital Clínico Universitario de Valencia, Valencia, Spain. Valero,M Hematology División, Hospital Arnau de Vilanova, Valencia, Spain. Espigado,I Department of Hematology, University Hospital Virgen del Rocío/ University of Sevilla, CSIC/ Institute of Biomedicine of Sevilla, Sevilla, Spain. Saldaña,R Hematology División, Hospital de Jerez, Jerez, Spain. Sisinni,L Pediatric Hematology-Oncology División, Hospital la Paz, Madrid, Spain. Ribera,JM, Jimenez,MJ Hematology División, ICO-Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain. Trabazo,M Pediatric División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Gonzalez-Vicent,M Pediatric División, Hospital niño Jesús, Madrid, Spain. Fernández,N Hematology División, Hospital Marqués de Valdecilla, Santander, Spain. Talarn,C Hematology División, Hospital Joan XXIII, Tarragona, Spain. Cedillo,A Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Madrid, Spain. Piñana,JL Division of Clinical Hematology, Hospital Universitario la Fe de Valencia, Valencia, Spain. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Risk factor, Hematologic neoplasms, COVID-19, Coronavirus infections, Multicenter study, Retrospective studies, Polymerase chain reaction, Stem cell transplantation, SARS-CoV-2, Mortality, Factores de riesgo, Neoplasias hemtaológicas, Infecciones por coronavirus, Estudio multicéntrico, Estudio restrospectivo, Reacción en cadena de la polimerasa, Trasplante de células madre, Mortalidad, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::C-Reactive Protein, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Hematologic Neoplasms |
| الوصف: | Background: Prognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defined. Patients and methods: This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. Results: We included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n = 65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1-93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p = 0.02). Prognostic factors identified for day 45 overall mortality (OM) by logistic regression multivariate analysis included age > 70 years [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2-3.8, p = 0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6-5.2, p < 0.0001); ECOG 3-4 (OR, 2.56, 95% CI 1.4-4.7, p = 0.003); neutropenia (< 0.5 × 109/L) (OR 2.8, 95% CI 1.3-6.1, p = 0.01); and a C-reactive protein (CRP) > 20 mg/dL (OR 3.3, 95% CI 1.7-6.4, p < 0.0001). In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2-0.89 and OR 0.31, 95% CI 0.11-0.87, respectively, p = 0.02) whereas the use of hidroxycloroquine did not show significant improvement in OM (OR 0.64, 95% CI 0.37-1.1, P = 0.1). Conclusions: In most patients with hematological malignancies COVID-19 mortality was directly driven by older age, disease status, performance status, as well as by immune (neutropenia) parameters and level of inflammation (high CRP). Use of azithromycin and low dose corticosteroids may be of value in very severe COVID-19. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 16 p.; application/pdf |
| اللغة: | English |
| تدمد: | 2162-3619 |
| العلاقة: | https://ehoonline.biomedcentral.com/articles/10.1186/s40164-020-00177-zTest; Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020 Aug 25;9:21.; http://hdl.handle.net/10668/3275Test; PMC7445734 |
| DOI: | 10.1186/s40164-020-00177-z |
| الإتاحة: | https://doi.org/10.1186/s40164-020-00177-zTest http://hdl.handle.net/10668/3275Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.FA65A90F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21623619 |
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| DOI: | 10.1186/s40164-020-00177-z |