دورية أكاديمية
Exploiting the complexities of glioblastoma stem cells: insights for cancer initiation and therapeutic targeting
| العنوان: | Exploiting the complexities of glioblastoma stem cells: insights for cancer initiation and therapeutic targeting |
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| المؤلفون: | Vieira de Castro, Joana, Gonçalves, Celine Saraiva, Hormigo, Adília, Costa, Bruno Marques |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2020 |
| المجموعة: | Universidade of Minho: RepositóriUM |
| مصطلحات موضوعية: | cancer heterogeneity, GSCs microenvironment, molecular pathways, stem cell markers, therapy resistance, Ciências Médicas::Ciências da Saúde, Science & Technology |
| الوصف: | The discovery of glioblastoma stem cells (GSCs) in the 2000s revolutionized the cancer research field, raising new questions regarding the putative cell(s) of origin of this tumor type, and partly explaining the highly heterogeneous nature of glioblastoma (GBM). Increasing evidence has suggested that GSCs play critical roles in tumor initiation, progression, and resistance to conventional therapies. The remarkable oncogenic features of GSCs have generated significant interest in better defining and characterizing these cells and determining novel pathways driving GBM that could constitute attractive key therapeutic targets. While exciting breakthroughs have been achieved in the field, the characterization of GSCs is a challenge and the cell of origin of GBM remains controversial. For example, the use of several cell-surface molecular markers to identify and isolate GSCs has been a challenge. It is now widely accepted that none of these markers is, per se, sufficiently robust to distinguish GSCs from normal stem cells. Finding new strategies that are able to more efficiently and specifically target these niches could also prove invaluable against this devastating and therapy-insensitive tumor. In this review paper, we summarize the most relevant findings and discuss emerging concepts and open questions in the field of GSCs, some of which are, to some extent, pertinent to other cancer stem cells. ; J.V.C., C.S.G., and B.M.C. were supported by funds from the project NORTE-01-0145-FEDER-000013,supported by the Northern Portugal Regional Operational Programme (NORTE 2020) under the Portugal Partnership Agreement, through the European Regional Development Fund (FEDER), and by National funds,through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 32722427 |
| العلاقة: | UIDB/50026/2020; UIDP/50026/2020; https://www.mdpi.com/1422-0067/21/15/5278Test; Vieira de Castro, J.; Gonçalves, C.S.; Hormigo, A.; Costa, B.M. Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting. Int. J. Mol. Sci. 2020, 21, 5278.; https://hdl.handle.net/1822/66423Test |
| DOI: | 10.3390/ijms21155278 |
| الإتاحة: | https://doi.org/10.3390/ijms21155278Test https://hdl.handle.net/1822/66423Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.13833615 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 32722427 |
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| DOI: | 10.3390/ijms21155278 |