دورية أكاديمية
Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models
| العنوان: | Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models |
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| المؤلفون: | Foncelle, Alexandre, Mendes, Alexandre, Jedrzejewska-Szmek, Joanna, Valtcheva, Silvana, Berry, Hugues, Blackwell, Kim, T., Venance, Laurent |
| المساهمون: | Artificial Evolution and Computational Biology (BEAGLE), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Krasnow Institute for Advanced Study Fairfax, George Mason University Fairfax, Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria), ANR-14-NEUC-0003,DOPACIUMCITY,Dopamine modulation of calcium influx underlying synaptic plasticity(2014) |
| المصدر: | ISSN: 1662-5188 ; Frontiers in Computational Neuroscience ; https://inria.hal.science/hal-01809075Test ; Frontiers in Computational Neuroscience, 2018, 12, pp.49. ⟨10.3389/fncom.2018.00049⟩. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2018 |
| المجموعة: | Portail HAL de l'Université Lumière Lyon 2 |
| مصطلحات موضوعية: | timing-dependent long term potentiation, tLTP, timing-dependent long term depression, tLTD, spike-timing dependent plasticity, STDP, nitric oxide, NO, N-methyl-D-aspartate receptor, NMDAR, M X, metabotropic glutamatergic receptor, mGluR, muscarinic acetylcholine receptors, nAChRs, nicotinic acetylcholine receptors, muscarinic type-X receptor, Astrocytes, Noradrenaline, Dopamine, Spike-timing dependent plasticity (STDP), Credit assignment, Third factor, Eligibility Traces, GABA Modulators, Acetylcholine, Computational model, Hebbian plasticity, BDNF, ERK |
| الوصف: | International audience ; In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- versus postsynaptic spiking activity. Since STDP is in compliance with Hebb’s postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with NMDA receptor activation often posited as one of the main components. Numerous studies have unveiled a third component of this coincidence detection system, namely neuromodulation and glia activity shaping STDP. Even though dopaminergic control of STDP has most often been reported, acetylcholine, noradrenaline, nitric oxide, BDNF or GABA also has been shown to effectively modulate STDP. Furthermore, it has been demonstrated that astrocytes, via the release or uptake of glutamate, gate STDP expression. At the most fundamental level, the timing properties of STDP are expected to depend on the spatiotemporal dynamics of the underlying signaling pathways. However in most cases, due to technical limitations experiments grant only indirect access to these pathways. Computational models carefully constrained by experiments, allow for a better qualitative understanding of the molecular basis of STDP and its regulation by neuromodulators. Recently, computational models of calcium dynamics and signaling pathway molecules have started to explore STDP emergence in ex and in vivo-like conditions. These models are expected to reproduce better at least part of the complex modulation of STDP as anemergent property of the underlying molecular pathways. Elucidation of the mechanisms underlying STDP modulation and its consequences on network dynamics is of critical importance and will allow better understanding of the major mechanisms of memory storage and recall both in health and disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01809075; https://inria.hal.science/hal-01809075Test; https://inria.hal.science/hal-01809075v2/documentTest; https://inria.hal.science/hal-01809075v2/file/Foncelle_2018_ReviewSTDP.pdfTest |
| DOI: | 10.3389/fncom.2018.00049 |
| الإتاحة: | https://doi.org/10.3389/fncom.2018.00049Test https://inria.hal.science/hal-01809075Test https://inria.hal.science/hal-01809075v2/documentTest https://inria.hal.science/hal-01809075v2/file/Foncelle_2018_ReviewSTDP.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CA50C461 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fncom.2018.00049 |
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