دورية أكاديمية
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures
| العنوان: | Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures |
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| المؤلفون: | Simona Lattanzi 1, Michele Ascoli 2, Laura Canafoglia 3, Maria Paola Canevini 4 5, Sara Casciato 6, Emanuele Cerulli Irelli 7, Valentina Chiesa 4, Filippo Dainese 8, Giovanni De Maria 9, Giuseppe Didato 10, Giancarlo Di Gennaro 6, Giovanni Falcicchio 11, Martina Fanella 7, Massimo Gangitano 12, Angela La Neve 11, Oriano Mecarelli 7, Elisa Montalenti 13, Alessandra Morano 7, Federico Piazza 14, Chiara Pizzanelli 15, Patrizia Pulitano 7, Federica Ranzato 16, Eleonora Rosati 17, Laura Tassi 18, Carlo Di Bonaventura 7, BRIVAFIRST Group Collaborators, Affiliations collapse Collaborators BRIVAFIRST Group: Angela Alicino, Giovanni Assenza, Federica Avorio, Valeria Badioni, Paola Banfi, Emanuele Bartolini, Luca Manfredi Basili, Vincenzo Belcastro, Simone Beretta, Irene Berto, Martina Biggi, Giuseppe Billo, Giovanni Boero, Paolo Bonanni, Jole Bongiorno, Francesco Brigo, Emanuele Caggia, Claudia Cagnetti, Carmen Calvello, Edward Cesnik, Gigliola Chianale, Domenico Ciampanelli, Roberta Ciuffini, Dario Cocito, Donato Colella, Margerita Contento, Cinzia Costa, Eduardo Cumbo, Alfredo D'Aniello, Francesco Deleo, Jacopo C DiFrancesco, Roberta Di Giacomo, Alessandra Di Liberto, Elisabetta Domina, Francesco Donato, Fedele Dono, Vania Durante, Maurizio Elia, Anna Estraneo, Giacomo Evangelista, Maria Teresa Faedda, Ylenia Failli, Elisa Fallica, Jinane Fattouch, Alessandra Ferrari, Florinda Ferreri, Giacomo Fisco, Davide Fonti, Francesco Fortunato, Nicoletta Foschi, Teresa Francavilla, Rosita Galli, Sara Gasparini, Stefano Gazzina, Anna Teresa Giallonardo, Filippo Sean Giorgi, Loretta Giuliano, Francesco Habetswallner, Francesca Izzi, Benedetta Kassabian, Lorenzo Kiferle, Angelo Labate, Concetta Luisi, Matteo Magliani, Giulia Maira, Luisa Mari, Daniela Marino, Addolorata Mascia, Alessandra Mazzeo, Stefano Meletti, Chiara Milano, Annacarmen Nilo, Biagio Orlando, Francesco Paladin, Maria Grazia Pascarella, Chiara Pastori, Giada Pauletto, Alessia Peretti, Gabriella Perri, Marianna Pezzella, Marta Piccioli, Pietro Pignatta, Nicola Pilolli, Francesco Pisani, Laura Rosa Pisani, Fabio Placidi, Patrizia Pollicino, Vittoria Porcella, Monica Puligheddu, Stefano Quadri, Pier Paolo Quarato, Rui Quintas, Rosaria Renna, Adriana Rum, Enrico Michele Salamone, Ersilia Savastano, Maria Sessa, David Stokelj, Elena Tartara, Mario Tombini, Gemma Tumminelli, Anna Elisabetta Vaudano, Ilaria Viganò, Emanuela Viglietta, Aglaia Vignoli, Flavio Villani, Elena Zambrelli, Lelia Zummo |
| المساهمون: | 1, Simona Lattanzi, 2, Michele Ascoli, 3, Laura Canafoglia, 4 5, Maria Paola Canevini, 6, Sara Casciato, 7, Emanuele Cerulli Irelli, 4, Valentina Chiesa, 8, Filippo Dainese, 9, Giovanni De Maria, Didato 10, Giuseppe, 6, Giancarlo Di Gennaro, Falcicchio 11, Giovanni, 7, Martina Fanella, Gangitano 12, Massimo, La Neve 11, Angela, 7, Oriano Mecarelli, Montalenti 13, Elisa, 7, Alessandra Morano, Piazza 14, Federico, Pizzanelli 15, Chiara, 7, Patrizia Pulitano, Ranzato 16, Federica, Rosati 17, Eleonora, Tassi 18, Laura, 7, Carlo Di Bonaventura, Group Collaborators, Brivafirst, collapse Collaborators BRIVAFIRST Group: Angela Alicino, Affiliation, Assenza, Giovanni, Avorio, Federica, Badioni, Valeria, Banfi, Paola, Bartolini, Emanuele, Manfredi Basili, Luca, Belcastro, Vincenzo, Beretta, Simone, Berto, Irene, Biggi, Martina, Billo, Giuseppe, Boero, Giovanni, Bonanni, Paolo, Bongiorno, Jole, Brigo, Francesco, Caggia, Emanuele, Cagnetti, Claudia, Calvello, Carmen, Cesnik, Edward, Chianale, Gigliola, Ciampanelli, Domenico, Ciuffini, Roberta, Cocito, Dario, Colella, Donato, Contento, Margerita, Costa, Cinzia, Cumbo, Eduardo, D'Aniello, Alfredo, Deleo, Francesco, C DiFrancesco, Jacopo, Di Giacomo, Roberta, Di Liberto, Alessandra, Domina, Elisabetta, Donato, Francesco, Dono, Fedele, Durante, Vania, Elia, Maurizio, Estraneo, Anna, Evangelista, Giacomo, Teresa Faedda, Maria, Failli, Ylenia, Fallica, Elisa, Fattouch, Jinane, Ferrari, Alessandra, Ferreri, Florinda, Fisco, Giacomo, Fonti, Davide, Fortunato, Francesco, Foschi, Nicoletta, Francavilla, Teresa, Galli, Rosita, Gasparini, Sara, Gazzina, Stefano, Teresa Giallonardo, Anna, Sean Giorgi, Filippo, Giuliano, Loretta, Habetswallner, Francesco, Izzi, Francesca, Kassabian, Benedetta, Kiferle, Lorenzo, Labate, Angelo, Luisi, Concetta, Magliani, Matteo, Maira, Giulia, Mari, Luisa, Marino, Daniela, Mascia, Addolorata, Mazzeo, Alessandra, Meletti, Stefano, Milano, Chiara, Nilo, Annacarmen, Orlando, Biagio, Paladin, Francesco |
| بيانات النشر: | WILEY |
| سنة النشر: | 2022 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | antiseizure medication, brivaracetam, focal seizure, seizure freedom, sodium channel blocker, Adult, Double-Blind Method, Drug Therapy, Combination, Freedom, Human, Middle Aged, Pyrrolidinone, Seizure, Treatment Outcome, Anticonvulsant, Epilepsies, Partial |
| الوصف: | The maintenance of seizure control over time is a clinical priority in patients with epilepsy. The aim of this study was to assess the sustained seizure frequency reduction with adjunctive brivaracetam (BRV) in real-world practice. Patients with focal epilepsy prescribed add-on BRV were identified. Study outcomes included sustained seizure freedom and sustained seizure response, defined as a 100% and a >= 50% reduction in baseline seizure frequency that continued without interruption and without BRV withdrawal through the 12-month follow-up. Nine hundred ninety-four patients with a median age of 45 (interquartile range = 32-56) years were included. During the 1-year study period, sustained seizure freedom was achieved by 142 (14.3%) patients, of whom 72 (50.7%) were seizure-free from Day 1 of BRV treatment. Sustained seizure freedom was maintained for >= 6, >= 9, and 12 months by 14.3%, 11.9%, and 7.2% of patients from the study cohort. Sustained seizure response was reached by 383 (38.5%) patients; 236 of 383 (61.6%) achieved sustained >= 50% reduction in seizure frequency by Day 1, 94 of 383 (24.5%) by Month 4, and 53 of 383 (13.8%) by Month 7 up to Month 12. Adjunctive BRV was associated with sustained seizure frequency reduction from the first day of treatment in a subset of patients with uncontrolled focal epilepsy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35278335; info:eu-repo/semantics/altIdentifier/wos/WOS:000773290300001; volume:63; issue:5; firstpage:e42-e50; journal:EPILEPSIA; http://hdl.handle.net/11577/3447522Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129997773 |
| DOI: | 10.1111/epi.17223 |
| الإتاحة: | https://doi.org/10.1111/epi.17223Test http://hdl.handle.net/11577/3447522Test |
| رقم الانضمام: | edsbas.2A26A495 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/epi.17223 |
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