المؤلفون: Fangting Li, Qin Zhang, Xin Ying, Jing He, Yuebo Jin, Huiwen Xu, Yaobin Cheng, Mingwei Zhao

المصدر: BMC Ophthalmology, Vol 21, Iss 1, Pp 1-7 (2021)

مصطلحات موضوعية: Corneal nerve, Sjögren’s syndrome, In vivo confocal microscopy (IVCM), Dry eye disease, Ophthalmology, RE1-994

الوصف: Abstract Background The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. Methods This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. Results SS patients showed a shorter TBUT (P = 0.009) and Schirmer I test results (P = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups (P = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group (P = 0.001, P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2415Test

الوصول الحر: https://doaj.org/article/ecbbeca415614fd08858c03506c71415Test

المؤلفون: Fangting Li (522702), Qin Zhang (58638), Xin Ying (758093), Jing He (58446), Yuebo Jin (10309788), Huiwen Xu (635163), Yaobin Cheng (10791385), Mingwei Zhao (10791388)

مصطلحات موضوعية: Medicine, Cell Biology, Neuroscience, Physiology, Science Policy, Biological Sciences not elsewhere classified, Corneal nerve, Sjögren’s syndrome, In vivo confocal microscopy (IVCM), Dry eye disease

الوصف: Additional file 1: Supplementary Table 1. Statistical Results of Correlations Between Dry Eye Clinical Tests in the SSDE Group. Supplementary Table 2. Statistical Results of Correlations Between Dry Eye Clinical Tests in the NSDE Group.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Corneal_nerve_structure_in_patients_with_primary_Sj_gren_s_syndrome_in_China/14583682Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14583682.v1Test

المؤلفون: Qin Zhang, Huiwen Xu, Yuebo Jin, Fangting Li, Mingwei Zhao, Yaobin Cheng, Jing He, Xin Ying

المصدر: BMC Ophthalmology, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Ophthalmology

مصطلحات موضوعية: medicine.medical_specialty, China, Corneal nerve, Sjögren syndrome, Cornea, Ophthalmology, Tear meniscus height, medicine, Humans, In patient, Dry eye disease, Microscopy, Confocal, business.industry, Significant difference, Case-control study, General Medicine, RE1-994, medicine.disease, Control subjects, eye diseases, Sjogren's Syndrome, Case-Control Studies, Tears, Sjögren’s syndrome, Dry Eye Syndromes, In vivo confocal microscopy (IVCM), sense organs, Sjogren s, business, Research Article

الوصف: Background The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. Methods This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. Results SS patients showed a shorter TBUT (P = 0.009) and Schirmer I test results (P = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups (P = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group (P = 0.001, P P = 0.039, respectively). In the SS group, the mean nerve length was correlated with age and the Schirmer I test (r = − 0.519, P = 0.013 and r = 0.463, P = 0.035, respectively). Corneal staining was correlated with nerve density and the number of nerves (r = − 0.534, P = 0.013 and r = − 0.487, P = 0.025, respectively). Conclusions Sjögren syndrome dry eye (SSDE) patients have more severe clinical dry eye parameters than non-Sjögren dry eye disease (NSDE) patients. Compared with NSDE patients, we found that SSDE patients showed decreased corneal subbasal nerve density and numbers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc3e103f62e92f44d956ee062b0d2d9Test
https://doaj.org/article/ecbbeca415614fd08858c03506c71415Test

المؤلفون: Jiali Chen, Zhanguo Li, Miao Shao, Yaobin Cheng, Xiaolin Sun, Yuebo Jin, Jing Li, Xiaoying Zhang, Jing He, Xia Zhang, Fangting Li, Qin Zhang, Yichen Liang, Ruijun Zhang

المصدر: Journal of Immunology Research, Vol 2019 (2019)
Journal of Immunology Research

مصطلحات موضوعية: Adult, Male, lcsh:Immunologic diseases. Allergy, Exocrine gland, medicine.medical_specialty, Saliva, Article Subject, Immunology, Enzyme-Linked Immunosorbent Assay, Gastroenterology, Salivary Glands, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Internal medicine, medicine, Humans, Immunology and Allergy, Stage (cooking), Aged, Autoantibodies, Retrospective Studies, 030203 arthritis & rheumatology, Autoimmune disease, biology, business.industry, Autoantibody, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, eye diseases, SSS, stomatognathic diseases, Sjogren's Syndrome, medicine.anatomical_structure, Organ Specificity, Disease Progression, 030221 ophthalmology & optometry, biology.protein, Female, Antibody, business, lcsh:RC581-607, Biomarkers, Research Article

الوصف: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Due to the absence of specific clinical manifestations and biomarkers in the early stage, pSS is generally underrecognized. To elucidate the role of the tissue-specific autoantibodies (TSAs), i.e., anti-CA6, anti-SP1, and anti-PSP antibodies, we enrolled 137 pSS patients, 32 secondary Sjögren’s syndrome (sSS) patients, and 127 healthy controls (HCs), whose serum and saliva samples were collected. TSA levels were detected by ELISA, and the clinical and laboratory data was reviewed from the medical records. The analysis results showed the following: (1) Compared to HCs, the serum IgA levels of anti-CA6, anti-SP1 and anti-PSP were significantly higher in pSS as well as in sSS patients, and anti-CA6 IgG was also notably higher in pSS patients. (2) The positivity of anti-CA6, anti-PSP and all the three antibodies together were significantly increased in anti-SSA-negative pSS patients. (3) The average IgM levels of anti-CA6 and anti-SP1 decreased as the disease duration extended. (4) The anti-CA6-positive patients have significantly higher levels of serum IgA, while the anti-PSP-positive group has a notably higher serum IgM level. (5) Another autoantibody specific to the salivary glands, anti-α-fodrin antibody, was elevated in TSA-positive patients, especially in the anti-CA6-positive group. (6) Preliminary detection of saliva TSAs showed that all the IgG levels of these three antibodies increased significantly in pSS patients. In conclusion, TSAs improve diagnosis of pSS in the early stage, especially in anti-SSA-negative patients, and their tissue-specific nature indicates localized salivary injury, which deserves further studies to clarify the mechanism.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c44c9f6a1d149ab769c33a7dfc3d7e4Test
https://doaj.org/article/79dc33235b3742898621c85521a937a3Test