التفاصيل البيبلوغرافية
| العنوان: |
Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data. |
| المؤلفون: |
Fustero-Torre, Coral, Jiménez-Santos, María José, García-Martín, Santiago, Carretero-Puche, Carlos, García-Jimeno, Luis, Ivanchuk, Vadym, Di Domenico, Tomás, Gómez-López, Gonzalo, Al-Shahrour, Fátima |
| المصدر: |
Genome Medicine; 12/15/2021, Vol. 13 Issue 1, p1-15, 15p |
| مصطلحات موضوعية: |
RNA sequencing, CELL populations, HETEROGENEITY, DRUG repositioning, CELL lines |
| مستخلص: |
We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations. Additionally, Beyondcell determines the therapeutic differences among cell populations and generates a prioritised sensitivity-based ranking in order to guide drug selection. We performed Beyondcell analysis in five single-cell datasets and demonstrated that TCs can be exploited to target malignant cells both in cancer cell lines and tumour patients. Beyondcell is available at: https://gitlab.com/bu_cnio/beyondcellTest. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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