نتائج البحث - "Gregg L. Semenza"

1

Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

المؤلفون: Stanley G. Rockson, Dongeon Kim, Wen Tian, Shravani Pasupneti, Gongyong Peng, Matthew T. Cribb, Mark R. Nicolls, Gregg L. Semenza, J. Brandon Dixon, Xinguo Jiang, Eric J. Granucci, Allen B. Tu, F. Hernan Espinoza, Yesl Kim, Amber H. Lim, Petra Dahms

المصدر: J Clin Invest

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, government.form_of_government, Inflammation, Lymphatic System, Mice, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Angiopoietin-1, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, Humans, Lymphedema, Phosphorylation, Mice, Knockout, biology, business.industry, Endothelial Cells, Anatomical pathology, General Medicine, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Receptor, TIE-2, Angiopoietin receptor, Mice, Inbred C57BL, Disease Models, Animal, Lymphatic Endothelium, 030104 developmental biology, Lymphatic system, 030220 oncology & carcinogenesis, Cancer research, government, biology.protein, Female, sense organs, medicine.symptom, business, Homeostasis, Signal Transduction, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fd118d1a45e1038d5b2419bfd703efTest
https://doi.org/10.1172/jci136164Test

2

Heritable disorders of oxygen sensing

المؤلفون: Gregg L. Semenza

المصدر: American journal of medical genetics. Part AREFERENCES. 185(11)

مصطلحات موضوعية: 0301 basic medicine, von Hippel-Lindau Disease, Polycythemia, 030105 genetics & heredity, Disease pathogenesis, Von Hippel-Lindau syndrome, Diagnosis, Differential, 03 medical and health sciences, Genetics, Basic Helix-Loop-Helix Transcription Factors, Medicine, Humans, Genetic Predisposition to Disease, Oxygen sensing, Genetic Association Studies, Genetics (clinical), business.industry, Aryl Hydrocarbon Receptor Nuclear Translocator, Genetic Diseases, Inborn, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Pulmonary hypertension, Oxygen, Clear cell renal cell carcinoma, Red blood cell, 030104 developmental biology, medicine.anatomical_structure, Phenotype, Mutation, Cancer research, Hereditary Erythrocytosis, business, Biomarkers, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ea8326b092ee6215dba1126472f2f8Test
https://pubmed.ncbi.nlm.nih.gov/34655169Test

3

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

المؤلفون: Astrid Wietelmann, Soni Savai Pullamsetti, Chanil Valasarajan, Christian Muecke, Swati Dabral, Friedrich Grimminger, Thomas Muley, Werner Seeger, Christos Samakovlis, Gregg L. Semenza, Rajkumar Savai, Norbert Weissmann, Mario Schmoranzer, Michael Meister, Tamina Seeger-Nukpezah

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Male, Lung Neoplasms, General Physics and Astronomy, 02 engineering and technology, Mice, Glycolysis, lcsh:Science, Promoter Regions, Genetic, Lung, Protein Kinase C, Mice, Knockout, Multidisciplinary, Chemistry, 021001 nanoscience & nanotechnology, Warburg effect, Cell Hypoxia, Knockout mouse, Hypertension, NADPH Oxidase 1, Phosphorylation, medicine.symptom, Signal transduction, 0210 nano-technology, Protein Binding, Signal Transduction, musculoskeletal diseases, endocrine system, Hypertension, Pulmonary, Science, Myocytes, Smooth Muscle, Primary Cell Culture, Pulmonary Artery, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Animals, Humans, Protein kinase A, Respiratory tract diseases, Tumor Suppressor Proteins, General Chemistry, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, Proteolysis, Cancer research, lcsh:Q, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd76cb600e390bc5f1c15028a4fa5658Test
https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98dTest

4

Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment

المؤلفون: Gregg L. Semenza, Jie Lan, Ivan Chen, Linh Tran, Yangyiran Xie, Haiquan Lu, Youngrok Park

المصدر: Cancer Research. 78:4191-4202

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Homeobox protein NANOG, Cancer Research, Transcription, Genetic, MAP Kinase Signaling System, Antineoplastic Agents, Triple Negative Breast Neoplasms, Biology, p38 Mitogen-Activated Protein Kinases, Metastasis, Kruppel-Like Factor 4, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, RNA, Messenger, Phosphorylation, Regulation of gene expression, Forkhead Box Protein O3, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, KLF4, Neoplastic Stem Cells, FOXO3, Cancer research, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases, Female, Hypoxia-Inducible Factor 1, Signal transduction, Stem cell, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eda9dcda7111f9743eda942ec25305Test
https://doi.org/10.1158/0008-5472.can-18-0270Test

5

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

المؤلفون: Nanduri R. Prabhakar, Gregg L. Semenza, Jayasri Nanduri

المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L1096-L1100

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f727a147e95363b8a0e8caf2f5f01aTest
https://doi.org/10.1152/ajplung.00325.2017Test

6

Maintenance of redox homeostasis by hypoxia-inducible factors

المؤلفون: Debangshu Samanta, Gregg L. Semenza

المصدر: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 331-335 (2017)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f28f9bb88b65fe87b2095ac3f8949cTest
http://europepmc.org/articles/PMC5476461Test

7

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary Hypertension

المؤلفون: Ailan Zhang, Eiki Takimoto, Lucas W. Meuchel, Nicola M. Heller, Kazuyo Yamaji-Kegan, Gregg L. Semenza, Esra Elsaigh, Roger A. Johns

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 36:134-144

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Genotype, Hypertension, Pulmonary, Apoptosis, In Vitro Techniques, Pulmonary Artery, Vascular Remodeling, Biology, Article, Organ Culture Techniques, Cell Movement, Internal medicine, medicine, Animals, Humans, Hypoxia, Cells, Cultured, Bone Marrow Transplantation, Mice, Knockout, Tube formation, Interleukin-6, Macrophages, Hemodynamics, Epithelial Cells, Cell migration, Kinase insert domain receptor, Fibroblasts, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, Pulmonary hypertension, Mice, Inbred C57BL, Disease Models, Animal, Vascular endothelial growth factor A, Phenotype, Endocrinology, medicine.anatomical_structure, Hypoxia-inducible factors, Vascular resistance, Intercellular Signaling Peptides and Proteins, Female, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da8647d4f689e17e983447512528952Test
https://doi.org/10.1161/atvbaha.115.306710Test

8

Hypoxia-inducible factor 1 and breast cancer metastasis

المؤلفون: Huafeng Zhang, Zhao ji Liu, Gregg L. Semenza

المصدر: Journal of Zhejiang University-SCIENCE B. 16:32-43

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Hypoxia-Inducible Factor 1, Epithelial-Mesenchymal Transition, Reviews, Breast Neoplasms, Biology, General Biochemistry, Genetics and Molecular Biology, Metastasis, Mice, Breast cancer, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Neoplasm Invasiveness, Epithelial–mesenchymal transition, Neoplasm Metastasis, General Pharmacology, Toxicology and Pharmaceutics, Hypoxia, General Veterinary, Mammary Neoplasms, Experimental, Breast cancer metastasis, General Medicine, Hypoxia (medical), medicine.disease, Extravasation, Gene Expression Regulation, Neoplastic, Treatment Outcome, Female, Signal transduction, medicine.symptom, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed47d72388f3dbd9f0099a45860c19d5Test
https://doi.org/10.1631/jzus.b1400221Test

9

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

المؤلفون: Houjie Liang, John W. Bullen, Daniele M. Gilkes, Hongxia Hu, Lisha Xiang, Gregg L. Semenza, Weibo Luo, Debangshu Samanta, Haiquan Lu, Naoharu Takano

المصدر: Oncotarget

مصطلحات موضوعية: medicine.medical_treatment, Breast Neoplasms, Mice, SCID, SIAH1, Protein Serine-Threonine Kinases, Transfection, Targeted therapy, Small hairpin RNA, Mice, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Aldefluor assay, Animals, Humans, Medicine, Neoplasm Metastasis, Triple-negative breast cancer, 030304 developmental biology, Cell Nucleus, 0303 health sciences, biology, business.industry, Tumor Suppressor Proteins, mammospheres, targeted therapy, medicine.disease, 3. Good health, Ubiquitin ligase, Phenotype, Oncology, 030220 oncology & carcinogenesis, Immunology, triple-negative breast cancer, MCF-7 Cells, Neoplastic Stem Cells, biology.protein, Cancer research, Heterografts, Female, Hypoxia-Inducible Factor 1, Signal transduction, Stem cell, basal-like breast cancer, business, Acyltransferases, Priority Research Paper, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce54975077577724453f04d07096cdbTest
https://doi.org/10.18632/oncotarget.2997Test

10

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

المؤلفون: Naoharu Takano, Daniele M. Gilkes, Lisha Xiang, Gregg L. Semenza, Weibo Luo, Hongxia Hu

المصدر: Oncotarget

مصطلحات موضوعية: Male, Mice, SCID, Proto-Oncogene Proteins c-fyn, Mice, 0302 clinical medicine, Basic Helix-Loop-Helix Transcription Factors, AMPA receptor, GRIA2, RNA, Small Interfering, GRIA3, Receptor, 0303 health sciences, biology, Liver Neoplasms, SLC1A1, Glutamate receptor, hepatocellular carcinoma, Cell Hypoxia, Kidney Neoplasms, Excitatory Amino Acid Transporter 1, Gene Expression Regulation, Neoplastic, Excitatory Amino Acid Transporter 3, Oncology, Von Hippel-Lindau Tumor Suppressor Protein, 030220 oncology & carcinogenesis, Heterografts, RNA Interference, Signal transduction, Signal Transduction, Carcinoma, Hepatocellular, Glutamic Acid, clear cell renal carcinoma, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Receptors, AMPA, Carcinoma, Renal Cell, Cell Proliferation, 030304 developmental biology, Aryl Hydrocarbon Receptor Nuclear Translocator, HIF-1, Glutamic acid, Hypoxia-Inducible Factor 1, alpha Subunit, HEK293 Cells, biology.protein, Cancer research, Neoplasm Transplantation, Priority Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d979667b6b6d03d40aeac5d00d4dd519Test
https://doi.org/10.18632/oncotarget.2593Test

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