التفاصيل البيبلوغرافية
| العنوان: |
Effects of an MC4R Agonist on Food Intake in Overweight/obese Men. |
| المؤلفون: |
Stevens, Catherine, Maganti, Lata, Zhu, Haiyuan, Cosgrove, Denise, Swan, Suzanne, Shamp, Trisha, Rolls, Barbara, Blundell, John, Wagner, John A., Herman, Gary A. |
| المصدر: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA462-A462, 1/4p |
| مصطلحات موضوعية: |
DRUG receptors, OVERWEIGHT men, INGESTION, BODY weight, PLACEBOS, SIBUTRAMINE |
| مستخلص: |
The melanocortin 4 receptor may play an integral role in the regulation of food intake and body weight. MK-0493, a selective MC4R agonist, reduces food intake and body weight in preclinical species. Two studies were conducted to examine the acute anorexic effects of single doses of anti-obesity compounds in humans using an ad-libitum food intake model. Study 1 qualified this model; Study 2 evaluated the effects of MK-0493 on food intake. Both studies were randomized, placebo (PBO)-controlled, double-blind, 4-period, crossover studies in overweight/obese male subjects: single doses of study drug were followed by ad-lib meals (in ∼5-fold excess over standard portions) at 4, 10, 14 and 24hr post-dose to assess individual meal and 24hr energy (kcal) intake. Study 1 assessed the effects of sibutramine (SIB) 10 or 30mg, and PBO (PBO was administered in 2 different periods separated by 1-4 wks to evaluate test/retest reproducibility). Study 2 assessed the effects of MK-0493 200 or 500mg (a maximally tolerated dose), SIB 30mg (positive control), or PBO. In Study 1, energy intake was reasonably consistent across periods, as determined by intake at lunch following the administration of PBO in 2 different periods (intraclass correlation coefficient=0.575). SIB 30mg significantly (p<0.001) reduced energy intake by 29% at lunch and by 18% over the 24hr post-dose period relative to PBO, while 10mg had no significant effects. In Study 2, relative to PBO, there were small non-significant changes in 24hr energy intake with MK-0493 200mg (+3%; p=0.500) and 500mg (-7%; p=0.070), suggesting modest anorexic activity. Decreases in intake with SIB 30mg were similar to Study 1 (lunch 30%, 24hr 19%, p<0.001), and were not specific to any macronutrient. Overall, the results of these studies indicate that this food intake model yields reproducible results and may aid in predicting long term efficacy for anorexic compounds. Furthermore, the MC4R agonist, MK-0493, appears to have modest anorexic activity in obese/overweight men. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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