New Insights into the Link Between DNA Damage and Apoptosis
| العنوان: | New Insights into the Link Between DNA Damage and Apoptosis |
|---|---|
| المؤلفون: | Francesco Cecconi, Daniela De Zio, Valentina Cianfanelli |
| المصدر: | Antioxidants & Redox Signaling. 19:559-571 |
| بيانات النشر: | Mary Ann Liebert Inc, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Programmed cell death, Settore BIO/06, DNA Repair, Physiology, DNA damage, DNA repair, Clinical Biochemistry, Cell, Apoptosis, Biology, medicine.disease_cause, Biochemistry, medicine, Animals, Humans, Molecular Biology, General Environmental Science, Forum Review ArticlesCell Death (T.Y. Aw, Ed.), Cell Biology, Cell biology, Oxidative Stress, Crosstalk (biology), medicine.anatomical_structure, General Earth and Planetary Sciences, Tumor Suppressor Protein p53, Signal transduction, Oxidation-Reduction, Protein Processing, Post-Translational, Oxidative stress, DNA Damage, Signal Transduction |
| الوصف: | Significance: When lesions are unrepaired or there are defects in the DNA repair system, DNA damage is often correlated to apoptosis. However, different kinds of lesions and different degrees of lesion severity can trigger numerous signaling responses. Recent Advances: DNA repair proteins involved in specific DNA repair pathways can modulate the function or activity of some apoptotic factors, further emphasizing the crosstalk between DNA damage and cell death. Critical Issues: Here, we discuss the signaling networks that link DNA damage to apoptosis, and we focus on post-translational modifications, leading to crucial changes in protein behavior, following various kinds of DNA damage. Moreover, we analyze the existence of apoptosis-related functions of typical repair proteins, leading to diverse, often-overlapping, DNA damage responses. Future Directions: The better understanding of the regulation and the functionality of key DNA repair proteins, also involved in apoptosis regulation, has the potential of modulating the cell outcomes on DNA damage, particularly in the context of cancer treatment. Antioxid. Redox Signal. 19, 559–571. |
| تدمد: | 1557-7716 1523-0864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54527dc426415f2c1cc3080c5982d71cTest https://doi.org/10.1089/ars.2012.4938Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54527dc426415f2c1cc3080c5982d71c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577716 15230864 |
|---|