دورية أكاديمية
A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery
| العنوان: | A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery |
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| المؤلفون: | Yanase, Fumitaka, Bitker, Laurent, Hessels, Lara, Osawa, Eduardo, Naorungroj, Thummaporn, Cutuli, Salvatore L, Young, Paul J, Ritzema, Jay, Hill, Georgia, Latimer-Bell, Charlotte, Hunt, Anna, Eastwood, Glenn M, Hilton, Andrew, Bellomo, Rinaldo |
| المصدر: | Yanase , F , Bitker , L , Hessels , L , Osawa , E , Naorungroj , T , Cutuli , S L , Young , P J , Ritzema , J , Hill , G , Latimer-Bell , C , Hunt , A , Eastwood , G M , Hilton , A & Bellomo , R 2020 , ' A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery ' , Journal of cardiothoracic and vascular anesthesia , vol. 34 , no. 2 , pp. 409-416 . https://doi.org/10.1053/j.jvca.2019.08.034Test |
| سنة النشر: | 2020 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | cardiopulmonary bypass, hypotension, post-cardiac surgery, postoperative care, vasoplegia, vitamin C, ASCORBIC-ACID, ATRIAL-FIBRILLATION, SEPTIC SHOCK, SEPSIS, SUPPLEMENTATION, HYDROCORTISONE, MECHANISMS, THIAMINE |
| الوصف: | OBJECTIVE: To conduct a pilot feasibility and physiologic efficacy study of high-dose vitamin C in patients with vasoplegia after cardiac surgery. DESIGN: Prospective, double-blind, randomized, controlled trial. SETTING: Two tertiary intensive care units (ICUs). PARTICIPANTS: Post-cardiac surgery patients with vasoplegia. INTERVENTIONS: The authors randomly assigned the patients to receive either high-dose intravenous vitamin C (1,500 mg every 6 hours) or placebo. The primary outcome was time from randomization to resolution of vasoplegia. Secondary outcomes included total norepinephrine equivalent dose in the first 2 days, ICU length of stay, ICU mortality, and in-hospital mortality. MEASUREMENTS AND MAIN RESULTS: The authors studied 50 patients (25 patients in each arms). The mean (standard deviation) time to resolution of vasoplegia was 27.0 (16.5) hours in the vitamin C group versus 34.7 (41.1) hours in the placebo group (mean decrease with vitamin C of 7.7 hours, 95% confidence interval -10.5 to 25.9, p = 0.40). The median (interquartile range) norepinephrine equivalent dose in the first 2 days was 64.9 (23.5-236.5) µg/kg versus 47.4 (21.4-265.9) µg/kg in the vitamin C and placebo group (p = 0.75). The median duration of ICU admission was similar (1.4 [0.5-2.5] days and 1.5 [0.5-3.3] days in the vitamin C and placebo group; p = 0.36). Only 1 patient, in the vitamin C arm, died. CONCLUSION: In patients with post-cardiac surgery vasoplegia, high-dose vitamin C infusion was feasible, appeared safe, and, within the limitations of a pilot study, did not achieve statistically faster resolution of vasoplegia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/6d7e8dc9-f27f-4cee-abc8-c9aa7ce82c16Test |
| DOI: | 10.1053/j.jvca.2019.08.034 |
| الإتاحة: | https://doi.org/10.1053/j.jvca.2019.08.034Test https://hdl.handle.net/11370/6d7e8dc9-f27f-4cee-abc8-c9aa7ce82c16Test https://research.rug.nl/en/publications/6d7e8dc9-f27f-4cee-abc8-c9aa7ce82c16Test https://pure.rug.nl/ws/files/120512541/A_Pilot_Double_Blind_Randomized_Controlled_Trial_of_High_Dose_Intravenous_Vitamin_C_for_Vasoplegia_After_Cardiac_Surgery.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.178AD0CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1053/j.jvca.2019.08.034 |
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