المؤلفون: Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S.D., Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F.M., Joshi, Poonam, Karam, Oliver, Kneyber, Martin C.J., Lemson, Joris, MacLaren, Graeme, Mehta, Nilesh M., Møller, Morten Hylander, Newth, Christopher J.L., Nguyen, Trung C., Nishisaki, Akira, Nunnally, Mark E., Parker, Margaret M., Paul, Raina M., Randolph, Adrienne G., Ranjit, Suchitra, Romer, Lewis H., Scott, Halden F., Tume, Lyvonne N., Verger, Judy T., Williams, Eric A., Wolf, Joshua, Wong, Hector R., Zimmerman, Jerry J., Kissoon, Niranjan

المصدر: Weiss , S L , Peters , M J , Alhazzani , W , Agus , M S D , Flori , H R , Inwald , D P , Nadel , S , Schlapbach , L J , Tasker , R C , Argent , A C , Brierley , J , Carcillo , J , Carrol , E D , Carroll , C L , Cheifetz , I M , Choong , K , Cies , J J , Cruz , A T , De Luca , D , Deep , A , Faust , S N ....

مصطلحات موضوعية: Evidence-based medicine, Grading of Recommendations Assessment, Development and Evaluation criteria, Guidelines, Infection, Pediatrics, Sepsis, Septic shock, Surviving Sepsis Campaign

الوصف: Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. Design: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. Methods: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, “in our practice” statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. Results: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of ...

الإتاحة: https://doi.org/10.1007/s00134-019-05878-6Test
https://curis.ku.dk/portal/da/publications/survivingTest-sepsis-campaign-international-guidelines-for-the-management-of-septic-shock-and-sepsisassociated-organ-dysfunction-in-children(9171ed14-adbf-4e9c-9b46-e96ec393e2a9).html
http://www.scopus.com/inward/record.url?scp=85079082160&partnerID=8YFLogxKTest
https://europepmc.org/articles/pmc7095013?pdf=renderTest

المؤلفون: Weiss, Scott L, Peters, Mark J, Alhazzani, Waleed, Agus, Michael S D, Flori, Heidi R, Inwald, David P, Nadel, Simon, Schlapbach, Luregn J, Tasker, Robert C, Argent, Andrew C, Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D, Carroll, Christopher L, Cheifetz, Ira M, Choong, Karen, Cies, Jeffry J, Cruz, Andrea T, De Luca, Daniele, Deep, Akash, Faust, Saul N, De Oliveira, Claudio Flauzino, Hall, Mark W, Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F M, Joshi, Poonam, Karam, Oliver, Kneyber, Martin C J, Lemson, Joris, MacLaren, Graeme, Mehta, Nilesh M, Møller, Morten Hylander, Newth, Christopher J L, Nguyen, Trung C, Nishisaki, Akira, Nunnally, Mark E, Parker, Margaret M, Paul, Raina, Randolph, Adrienne G, Ranjit, Suchitra, Romer, Lewis H, Scott, Halden F, Tume, Lyvonne N, Verger, Judy T, Williams, Eric A, Wolf, Joshua, Wong, Hector R, Zimmerman, Jerry J, Kissoon, Niranjan, Tissieres, Pierre

المصدر: Pediatric and Adolescent Medicine

مصطلحات موضوعية: Adolescent, child, preschool, consensus, critical care, guidelines as topic, humans, infant, organ dysfunction scores, pediatrics, sepsis, Pediatric and Adolescent Medicine

العلاقة: https://institutionalrepository.aah.org/ped/62Test; https://xk8bg6rv9a.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:32030528Test

الإتاحة: https://doi.org/10.1007/s00134-019-05877-7Test
https://institutionalrepository.aah.org/ped/62Test
https://xk8bg6rv9a.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:32030528Test

المؤلفون: Parker, Margaret M.¹ (AUTHOR)

المصدر: Critical Care Medicine. Jan2022, Vol. 50 Issue 1, p148-150. 3p.

مصطلحات موضوعية: *SEPSIS, *NEONATAL sepsis, *SEPTIC shock

مستخلص: 2011; 364:, 2483-2495, 13 Weiss SL, Peters MJ, Alhazzani W. Executive summary: Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. For purposes of this editorial, "sepsis" will include the full spectrum of sepsis, severe sepsis, and septic shock. Keywords: children; definitions; mortality; organ dysfunction; pediatric sepsis; septic shock EN children definitions mortality organ dysfunction pediatric sepsis septic shock 148 150 3 12/21/21 20220101 NES 220101 Justice Potter Stewart's comment regarding pornography that while he "wouldn't attempt further to define it...I know it when I see it" could just as readily be said in reference to sepsis. [Extracted from the article]

المؤلفون: Evans, Idris V. R., Phillips, Gary S., Alpern, Elizabeth R., Angus, Derek C., Friedrich, Marcus E., Kissoon, Niranjan, Lemeshow, Stanley, Levy, Mitchell M., Parker, Margaret M., Terry, Kathleen M., Watson, R. Scott, Weiss, Scott L., Zimmerman, Jerry, Seymour, Christopher W.

المصدر: JAMA: Journal of the American Medical Association; 7/24/2018, Vol. 320 Issue 4, p358-367, 10p

مصطلحات موضوعية: SEPTICEMIA in children, HOSPITAL mortality, CHILD mortality, ANTIBIOTICS, BOLUS drug administration, THERAPEUTICS, SEPTICEMIA treatment, EMERGENCY medical services, HOSPITAL emergency services, LONGITUDINAL method, MANAGEMENT, MEDICAL protocols, RESEARCH funding, RISK assessment, SEPSIS, TIME, ODDS ratio

مصطلحات جغرافية: NEW York (State)

مستخلص: Importance: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus. Whether completing the bundle elements within 1 hour improves outcomes is unclear.Objective: To determine the risk-adjusted association between completing the 1-hour pediatric sepsis bundle and individual bundle elements with in-hospital mortality.Design, Settings, and Participants: Statewide cohort study conducted from April 1, 2014, to December 31, 2016, in emergency departments, inpatient units, and intensive care units across New York State. A total of 1179 patients aged 18 years and younger with sepsis and septic shock reported to the New York State Department of Health who had a sepsis protocol initiated were included.Exposures: Completion of a 1-hour sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour.Main Outcomes and Measures: Risk-adjusted in-hospital mortality.Results: Of 1179 patients with sepsis reported at 54 hospitals (mean [SD] age, 7.2 [6.2] years; male, 54.2%; previously healthy, 44.5%; diagnosed as having shock, 68.8%), 139 (11.8%) died. The entire sepsis bundle was completed in 1 hour in 294 patients (24.9%). Antibiotics were administered to 798 patients (67.7%), blood cultures were obtained in 740 patients (62.8%), and the fluid bolus was completed in 548 patients (46.5%) within 1 hour. Completion of the entire bundle within 1 hour was associated with lower risk-adjusted odds of in-hospital mortality (odds ratio [OR], 0.59 [95% CI, 0.38 to 0.93], P = .02; predicted risk difference [RD], 4.0% [95% CI, 0.9% to 7.0%]). However, completion of each individual bundle element within 1 hour was not significantly associated with lower risk-adjusted mortality (blood culture: OR, 0.73 [95% CI, 0.51 to 1.06], P = .10; RD, 2.6% [95% CI, -0.5% to 5.7%]; antibiotics: OR, 0.78 [95% CI, 0.55 to 1.12], P = .18; RD, 2.1% [95% CI, -1.1% to 5.2%], and fluid bolus: OR, 0.88 [95% CI, 0.56 to 1.37], P = .56; RD, 1.1% [95% CI, -2.6% to 4.8%]).Conclusions and Relevance: In New York State following a mandate for sepsis care, completion of a sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour was associated with lower risk-adjusted in-hospital mortality among patients with pediatric sepsis and septic shock. [ABSTRACT FROM AUTHOR]

: Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Levy, Mitchell M., Dellinger, R. Phillip, Townsend, Sean R., Linde-Zwirble, Walter T., Marshall, John C., Bion, Julian, Schorr, Christa, Artigas, Antonio, Ramsay, Graham, Beale, Richard, Parker, Margaret M., Gerlach, Herwig, Reinhart, Konrad, Silva, Eliezer, Harvey, Maurene, Regan, Susan, Angus, Derek C.

المصدر: Intensive Care Medicine; Feb2010, Vol. 36 Issue 2, p222-231, 10p, 5 Charts, 1 Graph

مصطلحات موضوعية: SEPSIS, SEPTIC shock, HEALTH outcome assessment, HOSPITAL wards, MORTALITY

مستخلص: The Surviving Sepsis Campaign (SSC or “the Campaign”) developed guidelines for management of severe sepsis and septic shock. A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations on process improvement and patient outcomes. A multifaceted intervention to facilitate compliance with selected guideline recommendations in the ICU, ED, and wards of individual hospitals and regional hospital networks was implemented voluntarily in the US, Europe, and South America. Elements of the guidelines were “bundled” into two sets of targets to be completed within 6 h and within 24 h. An analysis was conducted on data submitted from January 2005 through March 2008. Data from 15,022 subjects at 165 sites were analyzed to determine the compliance with bundle targets and association with hospital mortality. Compliance with the entire resuscitation bundle increased linearly from 10.9% in the first site quarter to 31.3% by the end of 2 years ( P < 0.0001). Compliance with the entire management bundle started at 18.4% in the first quarter and increased to 36.1% by the end of 2 years ( P = 0.008). Compliance with all bundle elements increased significantly, except for inspiratory plateau pressure, which was high at baseline. Unadjusted hospital mortality decreased from 37 to 30.8% over 2 years ( P = 0.001). The adjusted odds ratio for mortality improved the longer a site was in the Campaign, resulting in an adjusted absolute drop of 0.8% per quarter and 5.4% over 2 years (95% CI, 2.5–8.4%). The Campaign was associated with sustained, continuous quality improvement in sepsis care. Although not necessarily cause and effect, a reduction in reported hospital mortality rates was associated with participation. The implications of this study may serve as an impetus for similar improvement efforts. [ABSTRACT FROM AUTHOR]

: Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Dellinger, R. Phillip, Levy, Mitchell M., Carlet, Jean M., Bion, Julian, Parker, Margaret M., Jaeschke, Roman, Reinhart, Konrad, Angus, Derek C., Brun-Buisson, Christian, Beale, Richard, Calandra, Thierry, Dhainaut, Jean-Francois, Gerlach, Herwig, Harvey, Maurene, Marini, John J., Marshall, John, Ranieri, Marco, Ramsay, Graham, Sevransky, Jonathan, Thompson, B.

المصدر: Intensive Care Medicine; Jan2008, Vol. 34 Issue 1, p17-60, 44p, 1 Diagram, 5 Charts

مصطلحات موضوعية: SEPSIS, SEPTIC shock, SHOCK (Pathology), DELPHI method, CRITICAL care medicine

مستخلص: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, “Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock,” published in 2004. Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted independently of any industry funding. We used the GRADE system to guide assessment of quality of evidence from high (A) to very low (D) and to determine the strength of recommendations. A strong recommendation [] indicates that an intervention's desirable effects clearly outweigh its undesirable effects (risk, burden, cost), or clearly do not. Weak recommendations [] indicate that the tradeoff between desirable and undesirable effects is less clear. The grade of strong or weak is considered of greater clinical importance than a difference in letter level of quality of evidence. In areas without complete agreement, a formal process of resolution was developed and applied. Recommendations are grouped into those directly targeting severe sepsis, recommendations targeting general care of the critically ill patient that are considered high priority in severe sepsis, and pediatric considerations. Key recommendations, listed by category, include: early goal-directed resuscitation of the septic patient during the first 6 hrs after recognition (1C); blood cultures prior to antibiotic therapy (1C); imaging studies performed promptly to confirm potential source of infection (1C); administration of broad-spectrum antibiotic therapy within 1 hr of diagnosis of septic shock (1B) and severe sepsis without septic shock (1D); reassessment of antibiotic therapy with microbiology and clinical data to narrow coverage, when appropriate (1C); a usual 7–10 days of antibiotic therapy guided by clinical response (1D); source control with attention to the balance of risks and benefits of the chosen method (1C); administration of either crystalloid or colloid fluid resuscitation (1B); fluid challenge to restore mean circulating filling pressure (1C); reduction in rate of fluid administration with rising filing pressures and no improvement in tissue perfusion (1D); vasopressor preference for norepinephrine or dopamine to maintain an initial target of mean arterial pressure ≥ 65 mm Hg (1C); dobutamine inotropic therapy when cardiac output remains low despite fluid resuscitation and combined inotropic/vasopressor therapy (1C); stress-dose steroid therapy given only in septic shock after blood pressure is identified to be poorly responsive to fluid and vasopressor therapy (2C); recombinant activated protein C in patients with severe sepsis and clinical assessment of high risk for death (2B except 2C for post-operative patients). In the absence of tissue hypoperfusion, coronary artery disease, or acute hemorrhage, target a hemoglobin of 7–9 g/dL (1B); a low tidal volume (1B) and limitation of inspiratory plateau pressure strategy (1C) for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS); application of at least a minimal amount of positive end-expiratory pressure in acute lung injury (1C); head of bed elevation in mechanically ventilated patients unless contraindicated (1B); avoiding routine use of pulmonary artery catheters in ALI/ARDS (1A); to decrease days of mechanical ventilation and ICU length of stay, a conservative fluid strategy for patients with established ALI/ARDS who are not in shock (1C); protocols for weaning and sedation/analgesia (1B); using either intermittent bolus sedation or continuous infusion sedation with daily interruptions or lightening (1B); avoidance of neuromuscular blockers, if at all possible (1B); institution of glycemic control (1B) targeting a blood glucose < 150 mg/dL after initial stabilization ( 2C );... [ABSTRACT FROM AUTHOR]

: Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Dellinger, R. Phillip, Carlet, Jean M., Masur, Henry, Gerlach, Herwig, Calandra, Thierry, Cohen, Jonathan, Gea-Banacloche, Juan, Keh, Didier, Marshall, John C., Parker, Margaret M., Ramsay, Graham, Zimmerman, Janice L., Vincent, Jean-Louis, Levy, M. M.

المصدر: Intensive Care Medicine; Apr2004, Vol. 30 Issue 4, p536-555, 20p

مصطلحات موضوعية: SEPSIS, COMMUNICABLE diseases, BLOOD diseases, MEDICAL care, PUBLIC health, HEALTH

مستخلص: Objective: To develop management guidelines for severe sepsis and septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and improve outcome in severe sepsis.Design: The process included a modified Delphi method, a consensus conference, several subsequent smaller meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. The modified Delphi methodology used for grading recommendations built upon a 2001 publication sponsored by the International Sepsis Forum. We undertook a systematic review of the literature graded along 5 levels to create recommendation grades from A-E, with A being the highest grade. Pediatric considerations were provided to contrast adult and pediatric management.Participants: Participants included 44 critical care and infectious disease experts representing 11 international organizations.Results: A total of 46 recommendations plus pediatric management considerations.Conclusions: Evidence-based recommendations can be made regarding many aspects of the acute management of sepsis and septic shock that will hopefully translate into improved outcomes for the critically ill patient. The impact of these guidelines will be formally tested and guidelines updated annually, and even more rapidly when some important new knowledge becomes available. [ABSTRACT FROM AUTHOR]

: Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Agus, Michael S. D.^1,2, Parker, Margaret M.^3,4

المصدر: Critical Care Medicine. Apr2018, Vol. 46 Issue 4, p493-493. 1p.

مصطلحات موضوعية: *RANDOMIZED controlled trials, *GLUCOCORTICOIDS

مستخلص: A foreword to the journal "Critical Care Medicine" is presented.

المؤلفون: Dellinger, R. Phillip¹ (AUTHOR) dellinger-phil@cooperhealth.edu, Rhodes, Andrew² (AUTHOR), Evans, Laura³ (AUTHOR), Alhazzani, Waleed⁴ (AUTHOR), Beale, Richard⁵ (AUTHOR), Jaeschke, Roman⁶ (AUTHOR), Machado, Flavia R.⁷ (AUTHOR), Masur, Henry⁸ (AUTHOR), Osborn, Tiffany⁹ (AUTHOR), Parker, Margaret M.¹⁰ (AUTHOR), Schorr, Christa¹¹ (NURSE), Townsend, Sean R.¹² (AUTHOR), Levy, Mitchell M.¹³ (AUTHOR)

المصدر: Critical Care Medicine. Apr2023, Vol. 51 Issue 4, p431-444. 14p.

مصطلحات موضوعية: *CRITICALLY ill patient care, *SEPSIS, *CENTRAL venous pressure, *SEPTIC shock, *CORONAVIRUS diseases, *NEONATAL sepsis

المؤلفون: Rubulotta, Francesca M.¹ frubulotta@hotmail.com, Ramsay, Graham², Parker, Margaret M.³, Dellinger, R. Phillip⁴, Levy, Mitchell M.⁵, Poeze, Martijn⁶

المصدر: Critical Care Medicine. Jan2009, Vol. 37 Issue 1, p167-170. 4p. 3 Charts, 1 Graph.

مصطلحات موضوعية: *SEPSIS, *HEALTH surveys, *PUBLIC opinion, *DEATH

مصطلحات جغرافية: EUROPE, UNITED States

مستخلص: The article discusses the results of an international survey on public attitude and perception of sepsis in Europe and the U.S. According to the survey, a mean of 88% of respondents in Italy, Spain, Great Britain, France and the U.S. had never heard of the term sepsis, while 58% did not recognize that sepsis is a leading cause of death. The survey revealed that 53% of people in Germany knew the word sepsis.