دورية أكاديمية
The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction
| العنوان: | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
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| المؤلفون: | Mihaljević Olgica, Živančević-Simonović Snežana, Lučić-Tomić Aleksandra, Živković Irena, Minić Rajna, Mijatović-Teodorović Ljiljana, Jovanović Zorica, Anđelković Marija, Stanojević-Pirković Marijana |
| المصدر: | Journal of Medical Biochemistry, Vol 39, Iss 4, Pp 436-443 (2020) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | beta-cross-laps, bone metabolism, osteocalcin, sclerostin, thyroid dysfunction, Biochemistry, QD415-436 |
| الوصف: | Background: The aim of this study was to compare serum sclerostin concentrations in patients with thyroid dysfunction with euthyroid control subjects and to assess the relationship between sclerostin and markers of bone metabolism (osteocalcin and beta-cross-laps). Methods: The study included 30 patients with thyroid dysfunction (hypothyroidism, hyperthyroidism and subclinical hyperthyroidism) and ten euthyroid controls. Free thyroxine (FT4) was measured by radioimmunoassay, while thyroid stimulating hormone (TSH) concentration was determined immunoradiometrically. We used an ELISA kit to determine the sclerostin level. The electrochemiluminescence method was applied for measuring the bone markers. Results: Sclerostin levels were significantly lower in hypothyroid patients (p=0.009) and significantly elevated in hyperthyroid patients (p=0.008) compared to control values. Hyperthyroid patients also had higher sclerostin than patients with subclinical hyperthyroidism (p=0.013). Sclerostin concentrations were negatively correlated with TSH levels (r=-0.746, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| العلاقة: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582004436M.pdfTest; https://doaj.org/toc/1452-8258Test; https://doaj.org/toc/1452-8266Test |
| الوصول الحر: | https://doaj.org/article/d281ebab810341829b7322a5f42f0101Test |
| رقم الانضمام: | edsdoj.281ebab810341829b7322a5f42f0101 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14528258 14528266 |
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