دورية أكاديمية
Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
| العنوان: | Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis |
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| المؤلفون: | Singh, B, Lant, S, Cividini, S, Cattrall, JWS, Goodwin, LC, Benjamin, L, Michael, BD, Khawaja, A, Brasil Matos, ADM, Alkeridy, W, Pilotto, A, Lahiri, D, Rawlinson, R, Mhlanga, S, Lopez, EC, Sargent, BF, Somasundaran, A, Tamborska, A, Webb, G, Younas, K, Al Sami, Y, Babu, H, Banks, T, Cavallieri, F, Cohen, M, Davies, E, Dhar, S, Modol, AF, Farooq, H, Harte, J, Hey, S, Joseph, A, Karthikappallil, D, Kassahun, D, Lipunga, G, Mason, R, Minton, T, Mond, G, Poxon, J, Rabas, S, Soothill, G, Zedde, M, Yenkoyan, K, Brew, B, Contini, E, Cysique, L, Zhang, X, Maggi, P, Van Pesch, V, Lechien, J, Saussez, S, Heyse, A, Brito Ferreira, ML, Soares, CN, Elicer, I, Eugenin-von Bernhardi, L, Nancupil Reyes, W, Yin, R, Azab, MA, Abd-Allah, F, Elkady, A, Escalard, S, Corvol, J-C, Delorme, C, Tattevin, P, Bigaut, K, Lorenz, N, Hornuss, D, Hosp, J, Rieg, S, Wagner, D, Knier, B, Lingor, P, Winkler, AS, Sharifi-Razavi, A, Moein, ST, SeyedAlinaghi, S, JamaliMoghadamSiahkali, S, Morassi, M, Padovani, A, Giunta, M, Libri, I, Beretta, S, Ravaglia, S, Foschi, M, Calabresi, P, Primiano, G, Servidei, S, Mercuri, NB, Liguori, C, Pierantozzi, M, Sarmati, L, Boso, F, Garazzino, S, Mariotto, S, Patrick, KN, Costache, O, Pincherle, A, Klok, FA, Meza, R, Cabreira, V, Valdoleiros, SR, Oliveira, V, Kaimovsky, I, Guekht, A, Koh, J, Fernandez Diaz, E, Maria Barrios-Lopez, J, Guijarro-Castro, C, Beltran-Corbellini, A, Martinez-Poles, J, Maria Diezma-Martin, A, Isabel Morales-Casado, M, Garcia Garcia, S, Breville, G, Coen, M, Uginet, M, Bernard-Valnet, R, Du Pasquier, R, Kaya, Y, Abdelnour, LH, Rice, C, Morrison, H, Defres, S, Huda, S, Enright, N, Hassell, J, D'Anna, L, Benger, M, Sztriha, L, Raith, E, Chinthapalli, K, Nortley, R, Paterson, R, Chandratheva, A, Werring, DJ, Dervisevic, S, Harkness, K, Pinto, A, Jillella, D, Beach, S, Gunasekaran, K, Ferreira Da Silva, IR, Nalleballe, K, Santoro, J, Scullen, T, Kahn, L, Kim, CY, Thakur, KT, Jain, R, Umapathi, T, Nicholson, TR, Sejvar, JJ, Hodel, EM, Smith, CT, Solomon, T |
| المصدر: | 26 ; 1 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, PROVISIONAL CASE DEFINITIONS, COVID-19, Hospitalization, Humans, Prognosis, Risk Factors, Stroke, Brain Infections Global COVID-Neuro Network Study Group, General Science & Technology |
| الوصف: | Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67–82]), than encephalopathy (54% [42–65]). Intensive care use was high (38% [35–41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27–32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | PLoS One; http://hdl.handle.net/10044/1/100279Test |
| DOI: | 10.1371/journal.pone.0263595 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0263595Test http://hdl.handle.net/10044/1/100279Test |
| حقوق: | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. ; https://creativecommons.org/publicdomain/zero/1.0Test/ |
| رقم الانضمام: | edsbas.B3E1B2C6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0263595 |