دورية أكاديمية
The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
| العنوان: | The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1. |
|---|---|
| المؤلفون: | Linda Sundström, Susanna Myhre, Monika Sundqvist, Andrea Ahnmark, William McCoull, Piotr Raubo, Sam D Groombridge, Magnus Polla, Ann-Christin Nyström, Lisbeth Kristensson, Mats Någård, Maria Sörhede Winzell |
| المصدر: | PLoS ONE, Vol 12, Iss 12, p e0189060 (2017) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | The mechanism behind the glucose lowering effect occurring after specific activation of GPR120 is not completely understood. In this study, a potent and selective GPR120 agonist was developed and its pharmacological properties were compared with the previously described GPR120 agonist Metabolex-36. Effects of both compounds on signaling pathways and GLP-1 secretion were investigated in vitro. The acute glucose lowering effect was studied in lean wild-type and GPR120 null mice following oral or intravenous glucose tolerance tests. In vitro, in GPR120 overexpressing cells, both agonists signaled through Gαq, Gαs and the β-arrestin pathway. However, in mouse islets the signaling pathway was different since the agonists reduced cAMP production. The GPR120 agonists stimulated GLP-1 secretion both in vitro in STC-1 cells and in vivo following oral administration. In vivo GPR120 activation induced significant glucose lowering and increased insulin secretion after intravenous glucose administration in lean mice, while the agonists had no effect in GPR120 null mice. Exendin 9-39, a GLP-1 receptor antagonist, abolished the GPR120 induced effects on glucose and insulin following an intravenous glucose challenge. In conclusion, GLP-1 secretion is an important mechanism behind the acute glucose lowering effect following specific GPR120 activation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://europepmc.org/articles/PMC5716539?pdf=renderTest; https://doaj.org/toc/1932-6203Test; https://doaj.org/article/0ae7af91f78b4d848a82f18a857194dbTest |
| DOI: | 10.1371/journal.pone.0189060 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0189060Test https://doaj.org/article/0ae7af91f78b4d848a82f18a857194dbTest |
| رقم الانضمام: | edsbas.ADD2BD01 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0189060 |