Activation of cGAS/STING pathway upon paramyxovirus infection
| العنوان: | Activation of cGAS/STING pathway upon paramyxovirus infection |
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| المؤلفون: | Cyrille Mathieu, Marion Ferren, Branka Horvat, Julia Spanier, Aude Charpenay, Mathieu Iampietro, Claire Dumont, Sébastien Dupichaud, Noémie Aurine, Rodolphe Pelissier, Stéphane Mély, Kévin P. Dhondt, Denis Gerlier, Ulrich Kalinke, Jonathan Robert |
| المساهمون: | Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre for Experimental and Clinical Infection Research [Hanover] (TWINCORE), Laboratoire P4 - Jean Mérieux, Centre Européen de Virologie/Immunologie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mathieu, Cyrille, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE11-0014,NiPah-C,Structure et fonctions de la protéine C du virus Nipah(2018) |
| المصدر: | iScience iScience, Elsevier, 2021, 24 (6), pp.102519. ⟨10.1016/j.isci.2021.102519⟩ iScience, 2021, 24 (6), pp.102519. ⟨10.1016/j.isci.2021.102519⟩ iScience, Vol 24, Iss 6, Pp 102519-(2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Science, Biology, Article, Measles virus, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Virology, molecular biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, Innate immune system, RNA, biology.organism_classification, eye diseases, 3. Good health, Sting, Cytosol, immune system, TRIF, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, biology.protein, Phosphorylation, 030217 neurology & neurosurgery |
| الوصف: | Summary During inflammatory diseases, cancer, and infection, the cGAS/STING pathway is known to recognize foreign or self-DNA in the cytosol and activate an innate immune response. Here, we report that negative-strand RNA paramyxoviruses, Nipah virus (NiV), and measles virus (MeV), can also trigger the cGAS/STING axis. Although mice deficient for MyD88, TRIF, and MAVS still moderately control NiV infection when compared with wild-type mice, additional STING deficiency resulted in 100% lethality, suggesting synergistic roles of these pathways in host protection. Moreover, deletion of cGAS or STING resulted in decreased type I interferon production with enhanced paramyxoviral infection in both human and murine cells. Finally, the phosphorylation and ubiquitination of STING, observed during viral infections, confirmed the activation of cGAS/STING pathway by NiV and MeV. Our data suggest that cGAS/STING activation is critical in controlling paramyxovirus infection and possibly represents attractive targets to develop countermeasures against severe disease induced by these pathogens. Graphical abstract Highlights • RNA sensors are insufficient for the effective control of paramyxovirus infection • STING adaptor protein is involved in controlling Nipah virus infection in mice • cGAS/STING axis is primordial for optimal production of IFN-I against NiV and MeV • STING protein can be activated during infections by RNA viruses Immune system; Molecular biology; Virology |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2589-0042 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5406cde8e5cb9d21c404578d2c9719efTest http://europepmc.org/articles/PMC8188492Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5406cde8e5cb9d21c404578d2c9719ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25890042 |
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