المؤلفون: Liang Chengyuan, Wenqiang Cao, Li Han, Li Jingyi, Xin YuWen, Jiayun Zhang, Xiaodong Ren, Jia Minyi, Taotao Qiang, Lei Tian, Minge Wan, Hong Liu

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: RNA virus, Antagonists & inhibitors, viruses, Allosteric regulation, RNA-dependent RNA polymerase, Review Article, Antiviral Agents, 01 natural sciences, Virus, 03 medical and health sciences, chemistry.chemical_compound, RNA polymerase, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Pandemics, 030304 developmental biology, chemistry.chemical_classification, Pharmacology, Nucleoside/non-nucleoside analogue inhibitor, 0303 health sciences, Coronavirus RNA-Dependent RNA Polymerase, biology, SARS-CoV-2, 010405 organic chemistry, Chemistry, Organic Chemistry, Drug Repositioning, COVID-19, RNA, Nucleosides, General Medicine, biology.organism_classification, Virology, RNA-dependent RNA polymerase (RdRp), COVID-19 Drug Treatment, 0104 chemical sciences, Enzyme

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c67bed8ca8d2219b6e71debbb45b7bTest

المؤلفون: Hui Nan, Xiaodong Ren, Pengcheng Yu, Hong Liu, Qiao Guaiping, Wenqiang Cao, Liu Yuzhi, Ju Xingke, Li Han, Jia Minyi, Lei Tian, Li Juan, Liang Chengyuan

المصدر: Phytomedicine Plus
Phytomedicine Plus, Vol 1, Iss 2, Pp 100027-(2021)

مصطلحات موضوعية: Vero E6, African Green Monkey Kidney Epithelial-6, Huh-7, Human Hepatocellular Carcinoma-7, 3CLpro, 3C-like protease, HPLC, High-performance liquid chromatography, MOI, Multiplicity of infection, MERS, Middle east respiratory syndrome, AECOPD, Acute exacerbation of chronic obstructive pulmonary disease, Pharmacology, Other systems of medicine, IP-10, Interferon-inducible protein-10, Medicine, CCL-2/MCP-1, C-C motif ligand 2/monocyte chemoattractant protein-1, gp-130, Glycoprotein 130, HSV-1, Herpes simplex virus type 1, General Pharmacology, Toxicology and Pharmaceutics, qPCR, Quantitative PCR, media_common, MTT, Methyl Thiazolyl Tetrazolium, ERK, Extracellular signal-regulated kinase, CC50, 50% Cytotoxic concentration, IAV, Influenza A virus, HIV, Human immunodeficiency virus, mIL-6R, Membrane-bound form IL-6 Receptor, RSV, Respiratory syncytial virus, IL-8, Interleukin-8, Drug, media_common.quotation_subject, TCID50, 50% Tissue culture infective dose, COPD, Chronic obstructive pulmonary disease, Pharmacy, Article, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, HVJ, Hemagglutinating virus of Japan, medicine.disease, IBV, Influenza B virus, Clinical trial, CSS, Cytokine storm syndrome, Complementary and alternative medicine, RZ201-999, MIP-1β, Macrophage Inflammatory Protein-1β, IL-6R, IL-6 Receptor, MAPK, Mitogen-activated protein kinase, MOF, Multifunctional organ damage, AQP3, Aquaporins 3, PKA/p-CREB, Protein kinase A /phosphorylated cAMP response element-binding protein, nsps, Non-structural proteins, CXCL-10/IP-10, C-X-C Motif Chemokine Ligand 10/ Interferon Gamma-induced Protein 10, IFN-λ1, Interferon-λ1, Pandemic, PKB, Akt, Protein kinase B, ORFs, Open reading frames, CAT, COPD assessment test, COVID-19, Coronavirus disease 2019, Grb2, Growth factor receptor-bound protein 2, biology, LD50, 50% Lethal dose, TD50, Half-toxic dose, Cytokine storm syndrome (CSS), MLD50, 50% Minimum lethal dose, Hep-2, Human epithelial type 2, FBS, Fatal bovine serum, LH capsules, Forsythia honeysuckle (Lianhuaqingwen) capsules, CT, Computed tomography, NF-kB, Nuclear transcription factor kappa-B, M protein, Membrane protein, RT-PCR, Reverse transcription PCR, PLpro, Papain-like proteases, PI3K, Phosphoinositide 3-kinases, MDCK, Madin-darby canine kidney, Coronavirus disease 2019 (COVID-19), MCP-1, Monocyte chemotactic protein 1, PBS, Phosphate buffered saline, E protein, Envelope protein, RANTES, Regulated on activation normal T cell expressed and secreted, CPE, Cytopathic effect, PRC, People's Republic of China, Forsythia, MEK, Mitogen-activated protein kinase kinase, ACE2, Angiotensin-converting enzyme 2, ARDS, Acute respiratory distress syndrome, PHN, Phillyrin, IL-6, Interleukin-6, AIDS, Acquired immune deficiency syndrome, JAK/STAT, Janus kinase/signal transducers and activators of transcription, IC50, 50% Inhibition concentration, QC, Quality control, SARS-CoV-2, business.industry, Lianhuaqingwen, COVID-19, Forsythia honeysuckle (Lianhuaqingwen,LH) capsules, biology.organism_classification, CFDA, China Food and Drug Administration, JAK1/2, Janus kinase1/2, 3C-like protease (3CLpro), Ras, Ras GTPase, business, Cytokine storm, NHC, National Health Commission, TD0, Non-toxic Dose

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6ee319ef2e397034c14aa22649908Test
https://doi.org/10.1016/j.phyplu.2021.100027Test

المؤلفون: Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu

المصدر: Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)

مصطلحات موضوعية: 0301 basic medicine, Coronaviruses, medicine.medical_treatment, viruses, Review, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, nsps, Non-structural proteins, Chloroquine, Medicine, CoV, Coronavirus, CQ, Chloroquine, HA, Haemagglutinin, Molecular Targeted Therapy, Enzyme Inhibitors, DAAs, Direct-acting antiviral agents, biology, FDA, US Food and Drug Administration, Therapies, Investigational, HTAs, Host-targeting antivirals, MERS-CoV, Middle East respiratory syndrome coronavirus, General Medicine, Small molecule, PIP2, Phosphatidylinositol 4,5-bisphosphate, RMP, Ribavirin monophosphate, IFN, Interferon, N, Nucleocapsid protein, COVID-19, 2019 Coronavirus disease, HIV, Human immunodeficiency virus, RBV, Ribavirin, NIAID, National Institute of Allergy and Infectious Diseases, 030220 oncology & carcinogenesis, 6MP, 6-Mercaptopurine, BSAs, Broad-spectrum antiviral drugs, RDP, Ribavirin diphosphate, EBOV, Ebola virus, Transmembrane serine protease (TMPRSS2), GTP, Guanosine triphosphate, medicine.drug, 3CLpro, 3C-Like protease, DHODH, Dihydroorotate dehydrogenase, 6TG, 6-Thioguanine, Papain-like protease (PLpro), TGN, Trans-Golgi network, RM1-950, Favipiravir, TMPRSS2, HyCoSuL, Hybrid Combinatorial Substrate Library, Antiviral Agents, PP2A, Protein phosphatase 2A, SARS-CoV, Severe acute respiratory syndrome coronavirus, WHO, World Health Organization, CPE, Cytopathic effect, PLpro, Papain-like protease, 03 medical and health sciences, EUA, Emergency use authorization, IRF3, Interferon regulatory factor 3, SAR, Structure-activity relationship, ACE2, Angiotensin-converting enzyme 2, S, Spike protein, SKP2, S-Phase kinase-associated protein 2, Humans, RdRp, RNA-dependent RNA polymerase, RTP, Ribavirin triphosphate, BECN1, Beclin1, ComputingMethodologies_COMPUTERGRAPHICS, Serine protease, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Protease, HC, QHydroxychloroquine, business.industry, SARS-CoV-2, Ribavirin, fungi, COVID-19, PC, Pro-protein convertase, DHO, Dihydroorotate, M, Membrane protein, RNA-dependent RNA polymerase (RdRp), COVID-19 Drug Treatment, AMPK, AMP-activated protein kinase, CMK, Decanoyl-RVKR-chloromethylketone, Mpro, Main protease, 030104 developmental biology, chemistry, 3C-like protease (3CLpro), E, Envelope protein, biology.protein, Dihydroorotate dehydrogenase, GM1, Monosialotetrahexosylganglioside 1, LPV/r, Lopinavir/ritonavir, Therapeutics. Pharmacology, ELs, Endolysosomes, business, IMPDH, Inosine monophosphate dehydrogenase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760af616f0938c4e771824446939551Test
http://europepmc.org/articles/PMC7857046Test

المؤلفون: Xie Xiaolin, Li Han, Lei Tian, Tang Yonghong, Zhang Dezhu, Zhenfeng Shi, Qiao Guaiping, Xu Zhao, Hui Nan, Liu Yuzhi, Liang Chengyuan

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: Drug, Emergency Use Authorization, Coronavirus disease 2019 (COVID-19), viruses, media_common.quotation_subject, Pneumonia, Viral, Review Article, Bioinformatics, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Betacoronavirus, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, Pandemic, medicine, Humans, Antiviral, Pandemics, 030304 developmental biology, media_common, Coronavirus, Pharmacology, Clinical Trials as Topic, 0303 health sciences, Alanine, SARS-CoV-2, 010405 organic chemistry, Chemistry, Organic Chemistry, COVID-19, General Medicine, Adenosine Monophosphate, COVID-19 Drug Treatment, 0104 chemical sciences, Clinical trial, RdRP inhibitor, Pharmacodynamics, Coronavirus Infections, Remdesivir (GS-5734)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b5672a987eecefebda7a3647630917Test
https://doi.org/10.1016/j.ejmech.2020.112527Test