المؤلفون: Salonia A., Pontillo M., Capogrosso P., Gregori S., Carenzi C., Ferrara A. M., Rowe I., Boeri L., Larcher A., Ramirez G. A., Tresoldi C., Locatelli M., Cavalli G., Dagna L., Castagna A., Zangrillo A., Tresoldi M., Landoni G., Rovere-Querini P., Ciceri F., Montorsi F.

المساهمون: A. Salonia, M. Pontillo, P. Capogrosso, S. Gregori, C. Carenzi, A.M. Ferrara, I. Rowe, L. Boeri, A. Larcher, G.A. Ramirez, C. Tresoldi, M. Locatelli, G. Cavalli, L. Dagna, A. Castagna, A. Zangrillo, M. Tresoldi, G. Landoni, P. Rovere-Querini, F. Ciceri, F. Montorsi

مصطلحات موضوعية: comorbiditie, COVID-19, follow-up, male, SARS-CoV-2, testosterone, Settore MED/24 - Urologia

الوصف: Background: Circulating testosterone levels have been found to be reduced in men with severe acute respiratory syndrome coronavirus 2 infection, COVID-19, with lower levels being associated with more severe clinical outcomes. Objectives: We aimed to assess total testosterone levels and the prevalence of total testosterone still suggesting for hypogonadism at 7-month follow-up in a cohort of 121 men who recovered from laboratory-confirmed COVID-19. Materials and methods: Demographic, clinical, and hormonal values were collected for all patients. Hypogonadism was defined as total testosterone ≤9.2nmol/L. The Charlson Comorbidity Index was used to score health-significant comorbidities. Descriptive statistics and multivariable linear and logistic regression models tested the association between clinical and laboratory variables and total testosterone levels at follow-up assessment. Results: Circulating total testosterone levels increased at 7-month follow-up compared to hospital admittance (p<0.0001), while luteinizing hormone and 17β-estradiol levels significantly decreased (all p≤0.02). Overall, total testosterone levels increased in 106 (87.6%) patients, but further decreased in 12 (9.9%) patients at follow-up, where a total testosterone level suggestive for hypogonadism was still observed in 66 (55%) patients. Baseline Charlson Comorbidity Index score (OR 0.36; p=0.03 [0.14, 0.89]) was independently associated with total testosterone levels at 7-month follow-up, after adjusting for age, BMI, and IL-6 at hospital admittance. Conclusions: Although total testosterone levels increased over time after COVID-19, more than 50% of men who recovered from the disease still had circulating testosterone levels suggestive for a condition of hypogonadism at 7-month follow-up. In as many as 10% of cases, testosterone levels even further decreased. Of clinical relevance, the higher the burden of comorbid conditions at presentation, the lower the probability of testosterone levels recovery over time.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34409772; info:eu-repo/semantics/altIdentifier/wos/WOS:000691259500001; volume:10; issue:1; firstpage:34; lastpage:41; numberofpages:8; journal:ANDROLOGY; http://hdl.handle.net/2434/892126Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85113842768

الإتاحة: https://doi.org/10.1111/andr.13097Test
http://hdl.handle.net/2434/892126Test

المؤلفون: Specchia M. L., Sapienza M., Riccardi M. T., Cicchetti A., Damiani G., Scaratti G., Ferrara F. M., Giorgio L., Rumi F., Favaretti C., Piria M.

المساهمون: Specchia, Maria Lucia, Di Pilla, A., Sapienza, Martina, Riccardi, Maria Teresa, Cicchetti, Americo, Damiani, Gianfranco, Pessina, E. A., Scaratti, Giuseppe, Basile, M., Di Bidino, R., Di Brino, E., Di Paolo, M. G., Ferrara, Fabrizio Massimo, Giorgio, Luca, Laurita, R., Gallo, M. V., Rumi, Filippo, Tattoli, A., Xoxi, E., Favaretti, Carlo, Silenzi, A., Piria, Marta, Reina, R., Ventura, M., Cristofaro, C. L., Vesperi, W., Melina, A. M., Gentile, T., Schiuma, G., Di Nauta, P., Ingrassia, R., Adinolfi, P., Di Guardo, C.

مصطلحات موضوعية: Community health services, Coronavirus, COVID-19, Healthcare organization, Healthcare system, Hospital, Management, Pandemic, Humans, Italy, Models, Organizational, SARS-CoV-2, Epidemics, Settore MED/42 - IGIENE GENERALE E APPLICATA

الوصف: As the COVID-19 outbreak traveled through various Italian regions, all national and local administrations issued measures to counter the spread of the contagion and organize healthcare. The Italian healthcare system is, indeed, a decentralized system with 21 regional health systems (RHSs), with different models of healthcare service delivery and organization. This study investigates whether a different organization of RHSs would have led to different management of the COVID-19 epidemic, and evaluates the effect of different approaches in epidemic management on the COVID-19 epidemiological trend. A set of indicators is identified by conducting an online synchronous Focus Group, involving an experts panel. A Pearson's correlation test was performed on the values assumed by the historical series of indicators investigate correlations among the trends represented by the indicators or between them and external factors. The comparison between the experiences of the different Italian regions, regarding the management of the epidemic, has helped to confirm and emphasize the importance of a community-based approach in health care—integrated with the hospital’s functions for the care of complex conditions and the need for specialized assistance.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34065117; info:eu-repo/semantics/altIdentifier/wos/WOS:000650230400001; volume:18; issue:9; firstpage:5008; lastpage:N/A; issueyear:2021; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; https://hdl.handle.net/10807/181304Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105426598

الإتاحة: https://doi.org/10.3390/ijerph18095008Test
https://hdl.handle.net/10807/181304Test

المؤلفون: Moccia, Lorenzo, Kotzalidis, Georgios D., Bartolucci, Giovanni, Ruggiero, Sara, Monti, Laura, Biscosi, Marco, Terenzi, Beatrice, Ferrara, Ottavia M., Mazza, Marianna, Di Nicola, Marco, Janiri, Delfina, Simonetti, Alessio, Caroppo, Emanuele, Janiri, Luigi, Sani, Gabriele

المصدر: Journal of Personalized Medicine; Jan2023, Vol. 13 Issue 1, p104, 10p

مصطلحات موضوعية: PSYCHOSES, COVID-19, BIPOLAR disorder, SARS-CoV-2, VIRUS diseases

مستخلص: Psychosis is a multifactorial condition that typically involves delusions, hallucinations, and disorganized thought, speech or behavior. The observation of an association between infectious epidemics and acute psychosis dates back to the last century. Recently, concerns have been expressed regarding COVID-19 and the risk for the development of new-onset psychosis. This article reviewed the current evidence of a possible link between SARS-CoV-2 and risk of psychosis as an acute or post-infectious manifestation of COVID-19. We here discuss potential neurobiological and environmental factors as well as a number of challenges in ascribing a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Personalized Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Salonia A., Pontillo M., Capogrosso P., Gregori S., Tassara M., Boeri L., Carenzi C., Abbate C., Cignoli D., Ferrara A. M., Cazzaniga W., Rowe I., Ramirez G. A., Tresoldi C., Mushtaq J., Locatelli M., Santoleri L., Castagna A., Zangrillo A., De Cobelli F., Tresoldi M., Landoni G., Rovere-Querini P., Ciceri F., Montorsi F.

المساهمون: A. Salonia, M. Pontillo, P. Capogrosso, S. Gregori, M. Tassara, L. Boeri, C. Carenzi, C. Abbate, D. Cignoli, A.M. Ferrara, W. Cazzaniga, I. Rowe, G.A. Ramirez, C. Tresoldi, J. Mushtaq, M. Locatelli, L. Santoleri, A. Castagna, A. Zangrillo, F. De Cobelli, M. Tresoldi, G. Landoni, P. Rovere-Querini, F. Ciceri, F. Montorsi

مصطلحات موضوعية: COVID-19, male, SARS-CoV-2, testosterone, Settore MED/24 - Urologia

الوصف: Background: Circulating androgens could have a relevant pathobiological role in clinical outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19). Objectives: We aimed to assess: (a) circulating sex steroids levels in a cohort of 286 symptomatic men with laboratory-confirmed COVID-19 at hospital admission compared to a cohort of 281 healthy men; and (b) the association between serum testosterone levels (tT), COVID-19, and clinical outcomes. Materials and Methods: Demographic, clinical, and hormonal values were collected for all patients. Hypogonadism was defined as tT ≤9.2nmol/l. The Charlson Comorbidity Index (CCI) was used to score health-significant comorbidities. Severe clinical outcomes were defined as patients either transferred to intensive care unit (ICU) or death. Descriptive statistics and multivariable linear and logistic regression models tested the association between clinical and laboratory variables and tT levels. Univariable and multivariable logistic regression models tested the association between tT and severe clinical outcomes. Results: Overall, a significantly lower levels of LH and tT were found in patients with COVID-19 compared to healthy controls (all p<0.0001); conversely, healthy controls depicted lower values of circulating E2 (p<0.001). Testosterone levels suggestive for hypogonadism were observed in 257 (89.8%) patients at hospital admission. In as many as 243 (85%) cases, hypogonadism was secondary. SARS-CoV-2 infection status was independently associated with lower tT levels (p<0.0001) and greater risk of hypogonadism (p<0.0001), after accounting for age, BMI, CCI, and IL-6 values. Lower tT levels were associated with higher risk of ICU admission and death outcomes (all p≤0.05), after accounting for clinical and laboratory parameters. Conclusions: We unveil an independent association between SARS-CoV-2 infection status and secondary hypogonadism already at hospital admission, with lower testosterone levels predicting the ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33635589; info:eu-repo/semantics/altIdentifier/wos/WOS:000626609000001; numberofpages:10; journal:ANDROLOGY; http://hdl.handle.net/2434/838874Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102296061

الإتاحة: https://doi.org/10.1111/andr.12993Test
http://hdl.handle.net/2434/838874Test

المؤلفون: Specchia, M. L., Di Pilla, A., Sapienza, M., Riccardi, M. T., Cicchetti, A., Damiani, G., Pessina, Eugenio Anessi, Scaratti, Giuseppe, Basile, Michele, Di Bidino, R., Di Brino, E., Di Paolo, M. G., Ferrara, F. M., Giorgio, L., Laurita, R., Gallo, M. V., Rumi, F., Tattoli, A., Xoxi, E., Favaretti, C., Silenzi, A., Piria, M., Reina, R., Ventura, M., Cristofaro, C. L., Vesperi, W., Melina, A. M., Gentile, T., Schiuma, G., Di Nauta, P., Ingrassia, R., Adinolfi, P., Di Guardo, C.

المصدر: International Journal of Environmental Research and Public Health, Vol 18, Iss 5008, p 5008 (2021)
International Journal of Environmental Research and Public Health
Volume 18
Issue 9

مصطلحات موضوعية: Community health services, Coronavirus, COVID-19, Healthcare organization, Healthcare system, Hospital, Management, Pandemic, Humans, Italy, Models, Organizational, SARS-CoV-2, Epidemics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Health, Toxicology and Mutagenesis, Phase (combat), Article, Organizational, 03 medical and health sciences, Settore M-PSI/06 - Psicologia del Lavoro e delle Organizzazioni, 0302 clinical medicine, Models, Health care, Epidemiology, Regional science, medicine, 030212 general & internal medicine, Set (psychology), Settore MED/42 - IGIENE GENERALE E APPLICATA, business.industry, Public Health, Environmental and Occupational Health, Focus group, Geography, Medicine, business, 030217 neurology & neurosurgery

الوصف: As the COVID-19 outbreak traveled through various Italian regions, all national and local administrations issued measures to counter the spread of the contagion and organize healthcare. The Italian healthcare system is, indeed, a decentralized system with 21 regional health systems (RHSs), with different models of healthcare service delivery and organization. This study investigates whether a different organization of RHSs would have led to different management of the COVID-19 epidemic, and evaluates the effect of different approaches in epidemic management on the COVID-19 epidemiological trend. A set of indicators is identified by conducting an online synchronous Focus Group, involving an experts panel. A Pearson’s correlation test was performed on the values assumed by the historical series of indicators investigate correlations among the trends represented by the indicators or between them and external factors. The comparison between the experiences of the different Italian regions, regarding the management of the epidemic, has helped to confirm and emphasize the importance of a community-based approach in health care—integrated with the hospital’s functions for the care of complex conditions and the need for specialized assistance.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30b8ff7b36ddd8809fac6ec458e4552Test
http://hdl.handle.net/10446/209374Test

المؤلفون: Scaratti, Giuseppe

المساهمون: Specchia, M. L., Di Pilla, A., Sapienza, M., Riccardi, M. T., Cicchetti, A., Damiani, G., Pessina, Eugenio Anessi, Scaratti, Giuseppe, Basile, Michele, Di Bidino, R., Di Brino, E., Di Paolo, M. G., Ferrara, F. M., Giorgio, L., Laurita, R., Gallo, M. V., Rumi, F., Tattoli, A., Xoxi, E., Favaretti, C., Silenzi, A., Piria, M., Reina, R., Ventura, M., Cristofaro, C. L., Vesperi, W., Melina, A. M., Gentile, T., Schiuma, G., Di Nauta, P., Ingrassia, R., Adinolfi, P., Di Guardo, C.

مصطلحات موضوعية: Community health service, Coronaviru, COVID-19, Healthcare organization, Healthcare system, Hospital, Management, Pandemic, Human, Italy, Models, Organizational, SARS-CoV-2, Epidemics, Settore M-PSI/06 - Psicologia del Lavoro e delle Organizzazioni

الوصف: As the COVID-19 outbreak traveled through various Italian regions, all national and local administrations issued measures to counter the spread of the contagion and organize healthcare. The Italian healthcare system is, indeed, a decentralized system with 21 regional health systems (RHSs), with different models of healthcare service delivery and organization. This study investigates whether a different organization of RHSs would have led to different management of the COVID-19 epidemic, and evaluates the effect of different approaches in epidemic management on the COVID-19 epidemiological trend. A set of indicators is identified by conducting an online synchronous Focus Group, involving an experts panel. A Pearson's correlation test was performed on the values assumed by the historical series of indicators investigate correlations among the trends represented by the indicators or between them and external factors. The comparison between the experiences of the different Italian regions, regarding the management of the epidemic, has helped to confirm and emphasize the importance of a community-based approach in health care—integrated with the hospital’s functions for the care of complex conditions and the need for specialized assistance.

وصف الملف: remote

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34065117; info:eu-repo/semantics/altIdentifier/wos/WOS:000650230400001; volume:18; issue:9 (art. 5008); firstpage:1; lastpage:14; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; http://hdl.handle.net/10446/209374Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105426598

الإتاحة: https://doi.org/10.3390/ijerph18095008Test
http://hdl.handle.net/10446/209374Test

المؤلفون: Massimo Locatelli, Lorenzo Dagna, Cristina Tresoldi, Moreno Tresoldi, Alessandro Larcher, Isaline Rowe, Luca Boeri, Giuseppe A. Ramirez, Anna Maria Ferrara, Giulio Cavalli, Andrea Salonia, Cristina Carenzi, Paolo Capogrosso, Silvia Gregori, Fabio Ciceri, Giovanni Landoni, Francesco Montorsi, Marina Pontillo, Patrizia Rovere-Querini, Antonella Castagna, Alberto Zangrillo

المساهمون: Salonia, A., Pontillo, M., Capogrosso, P., Gregori, S., Carenzi, C., Ferrara, A. M., Rowe, I., Boeri, L., Larcher, A., Ramirez, G. A., Tresoldi, C., Locatelli, M., Cavalli, G., Dagna, L., Castagna, A., Zangrillo, A., Tresoldi, M., Landoni, G., Rovere-Querini, P., Ciceri, F., Montorsi, F.

المصدر: Andrology

مصطلحات موضوعية: medicine.medical_specialty, Urology, Endocrinology, Diabetes and Metabolism, Disease, Logistic regression, comorbidities, SARS‐CoV‐2, Endocrinology, male, COVID‐19, Internal medicine, follow-up, Medicine, Clinical significance, follow‐up, SARS-CoV-2, business.industry, COVID-19, Testosterone (patch), Original Articles, Reproductive Medicine, Cohort, testosterone, Original Article, business, Luteinizing hormone, Hormone, Cohort study

الوصف: Background: Circulating testosterone levels have been found to be reduced in men with severe acute respiratory syndrome coronavirus 2 infection, COVID-19, with lower levels being associated with more severe clinical outcomes. Objectives: We aimed to assess total testosterone levels and the prevalence of total testosterone still suggesting for hypogonadism at 7-month follow-up in a cohort of 121 men who recovered from laboratory-confirmed COVID-19. Materials and methods: Demographic, clinical, and hormonal values were collected for all patients. Hypogonadism was defined as total testosterone ≤9.2nmol/L. The Charlson Comorbidity Index was used to score health-significant comorbidities. Descriptive statistics and multivariable linear and logistic regression models tested the association between clinical and laboratory variables and total testosterone levels at follow-up assessment. Results: Circulating total testosterone levels increased at 7-month follow-up compared to hospital admittance (p 

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87baf6a453f16a07863ababefc795960Test
http://europepmc.org/articles/PMC8444879Test