التفاصيل البيبلوغرافية
| العنوان: |
Characteristics and outcomes of adult patients in the PETHEMA registry with relapsed or refractory FLT3-ITD mutation-positive acute myeloid leukemia |
| المؤلفون: |
Martínez-Cuadron, D. (David), Serrano, J. (Josefina), Mariz, J. (José), Gil, C. (Cristina), Tormo, M. (Mar), Martínez-Sánchez, P. (Pilar), Rodríguez-Arbolí, E. (Eduardo), García-Boyero, R. (Raimundo), Rodríguez-Medina, C. (Carlos), Martínez-Chamorro, C. (Carmen), Polo, M. (Marta), Bergua, J. (Juan), Aguiar, E. (Eliana), Amigo, M.L. (Mari Luz), Herrera, P. (Pilar), Alonso-Domínguez, J.M. (Juan M.), Bernal, T. (Teresa), Espadana, A. (Ana), Sayas, M.J. (María J.), Algarra, L. (Lorenzo), Vidriales, M.B. (María Belén), Vasconcelos, G. (Graça), Vives, S. (Susana), Pérez-Encinas, M.M. (Manuel M.), López, A. (Andrés), Noriega, V. (Víctor), García-Fortes, M. (María), Chillón, M.C. (María del Carmen), Rodríguez-Gutiérrez, J.I. (Juan I.), Calasanz-Abinzano, M.J. (Maria Jose), Labrador, J. (Jorge), López, J.A. (Juan A.), Boluda, B. (Blanca), Rodríguez-Veiga, R. (Rebeca), Martínez-López, J. (Joaquín), Barragán, E. (Eva), Sanz, M.A. (Miguel A.), Montesinos, P. (Pau) |
| سنة النشر: |
2022 |
| المجموعة: |
dadun - Depósito Académico Digital Universidad de Navarra |
| مصطلحات موضوعية: |
Acute myeloid leukemia, FLT3-ITD mutation, Real-world outcomes, Relapsed, Refractory disease, Salvage therapy |
| الوصف: |
Simple Summary Most adult patients with acute myeloid leukemia (AML) relapse after achieving complete remission with chemotherapy; however, there is no standard second-line (salvage) treatment. We retrospectively investigated 404 patients aged >= 18 years with relapsed/refractory (R/R) AML with an FMS-like tyrosine kinase 3 (FLT3) mutation, treated at a PETHEMA (NCT02607059) site between 1998 and 2018. Patients received salvage treatment with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care (n = 80). Complete remission was achieved by 48% of patients who received intensive therapy vs. 19% with non-intensive therapy. Intensive/non-intensive therapy prolonged overall survival significantly compared with supportive therapy. Of evaluable patients, 22% received an allogeneic stem-cell transplant after complete remission. The majority of patients with FLT3-mutated R/R AML received intensive salvage therapy, with the best outcomes being obtained when intensive salvage treatment was combined with stem-cell transplant. This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1- and 5-year OS rates were 25% and 7%. OS was significantly (p < 0.001) prolonged with intensive or non-intensive salvage therapy compared with ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://hdl.handle.net/10171/63863Test |
| الإتاحة: |
https://hdl.handle.net/10171/63863Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.86B72085 |
| قاعدة البيانات: |
BASE |
