دورية أكاديمية
Rotavirus Prevalence and Genotype Distribution in Children with Acute Gastroenteritis in Adana Province
| العنوان: | Rotavirus Prevalence and Genotype Distribution in Children with Acute Gastroenteritis in Adana Province |
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| المؤلفون: | Gundeslioglu, Ozlem Ozgur, Kocabas, Emine, Haytoglu, Zeliha, Dayar, Gulperi Timurtas, Cil, Merve Kilic, Durmaz, Riza |
| المساهمون: | Çukurova Üniversitesi |
| بيانات النشر: | ANKARA MICROBIOLOGY SOC |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Rotavirus, genotype, children, surveillance |
| الوصف: | WOS: 000442850800005 ; PubMed ID: 29933733 ; Rotavirus is the most common agent of acute gastroenteritis in children under five years of age and still a major cause of mortality and morbidity mainly in devoloping countries. The aim of this study was to determine the circulating rotavirus genotypes in children less than five years of age with acute gastroenteritis in Adana province, before the introduction of the rotavirus vaccine into the national immunization programme. Fecal specimens were collected from children enrolled between December 2012 and November 2016 and rotavirus antigen was searched by a rapid immunochromatographic test method. The antigen positive samples were G and Pgenotyped by hemi-nested type-specific multiplex reverse-transcriptase polymerase chain reaction (RT-PCR). Rotavirus antigen positive fecal specimens from 201 patients of 107 (53.3%) boys and 94 (46.8%) girls were included in this study. Rotavirus infection was most frequently detected in patients with gastroenteritis between the ages of 12 and 23 months. It has been determined that 45% of rotavirus gastroenteritis was determined in children under two years of age. Rotavirus gastroenteritis was more frequent between September and April, but the highest incidence was detected in January. Of 201 rotavirus antigen-positive stool specimens, 167 were PCR positive. Five common G (G1, G2, G3, G4 and G9) and two common P genotypes (P[8] and P[4]) were determined as 91.6% and 96.4% of the isolates, respectively. The most prevalent G and P genotype combination was G1 P8 with a frequency of 29.9%, followed by 21% G9P8 About 78% of rotavirus isolates were classified into five common G-P combination genotypes, including G1P8, G9P8 G3P8, G2P4, and G2P8. During the study period, there were significant changes in the distribution of rotavirus genotype. The prevalence of G9P8 genotype sharply decreased from 40% to 8.1% and the prevalence of G1P8 genotype increased from 21.3% to 48.6%. Although no G3P8 isolates were detected in the first two years of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Turkish |
| تدمد: | 0374-9096 |
| العلاقة: | MIKROBIYOLOJI BULTENI; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.5578/mb.66648Test; https://hdl.handle.net/20.500.12605/9393Test; 52; 156; 165 |
| DOI: | 10.5578/mb.66648 |
| الإتاحة: | https://doi.org/20.500.12605/9393Test https://doi.org/10.5578/mb.66648Test https://hdl.handle.net/20.500.12605/9393Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5E604E5 |
| قاعدة البيانات: | BASE |
| تدمد: | 03749096 |
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| DOI: | 10.5578/mb.66648 |