التفاصيل البيبلوغرافية
| العنوان: |
Epitranscriptomic code and its alterations in human disease |
| المؤلفون: |
Kadumuri, Rajashekar Varma, Janga, Sarath Chandra |
| المساهمون: |
BioHealth Informatics, School of Informatics and Computing |
| المصدر: |
PMC |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2018 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
RNA modifications, Post-transcriptional regulation, Regulatory networks, Next generation sequencing, RNA metabolism |
| الوصف: |
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of RNAs and tissue types, have led to a surge in integrative approaches for transcriptome-wide mapping of modifications and protein-RNA interaction profiles of epitranscriptome players. RNA modification maps and crosstalk between them have begun to elucidate the role of modifications as signaling switches, entertaining the notion of an epitranscriptomic code as a driver of the post-transcriptional fate of RNA. Emerging single-molecule sequencing technologies and development of antibodies specific to various RNA modifications could enable charting of transcript-specific epitranscriptomic marks across cell types and their alterations in disease. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
Trends in Molecular Medicine; Kadumuri, R. V., & Janga, S. C. (2018). Epitranscriptomic Code and Its Alterations in Human Disease. Trends in molecular medicine, 24(10), 886–903. doi:10.1016/j.molmed.2018.07.010; https://hdl.handle.net/1805/21742Test |
| الإتاحة: |
https://hdl.handle.net/1805/21742Test |
| حقوق: |
Publisher Policy |
| رقم الانضمام: |
edsbas.474190A2 |
| قاعدة البيانات: |
BASE |
