دورية أكاديمية
PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET
| العنوان: | PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET |
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| المؤلفون: | L. V. Egshatyan, L. Ya. Rozhinskaya, N. S. Kuznetsov, M. Sh. Shamkhalova |
| المصدر: | Рациональная фармакотерапия в кардиологии, Vol 9, Iss 2, Pp 152-157 (2015) |
| بيانات النشر: | Столичная издательская компания, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | вторичный гиперпаратиреоз, паратиреоидэктомия, цинакалцет, почечная анемия, дислипидемия, артериальная гипертензия, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Aim. To evaluate the effect of parathyroidectomy and cinacalcet on anemia, lipid profile and blood pressure (BP) in uremic hyperparathyroidism.Material and methods. Uremic patients (n=39) treated with hemodialysis and having secondary hyperparathyroidism were included into the study. Radical parathyroidectomy was performed in 21 patients, 18 patients were treated with cinacalcet. BP measurement, determination of blood levels of albumin, total calcium, phosphorus, total cholesterol (TC), low (LDL) and high density lipoproteins, triglycerides, intact parathyroid hormone, and hemoglobin were performed in all patients initially and during treatment. Doses of antihypertensive and erythropoiesis-stimulating agents were also assessed.Results. Calcium-phosphorus metabolism indices improved after 6 months of cinacalcet therapy and parathyroidectomy (pConclusion. The pleiotropic effects (reduction in BP and atherogenic lipids levels, as well as decrease in anemia resistant to the action of erythropoiesis-stimulating agents) were found after parathyroidectomy and cinacalcet therapy additionally to calcium-phosphorus metabolism improvement. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 1819-6446 2225-3653 |
| العلاقة: | http://www.rpcardio.ru/jour/article/view/275Test; https://doaj.org/toc/1819-6446Test; https://doaj.org/toc/2225-3653Test |
| DOI: | 10.1234/1819-6446-2013-2-152-157 |
| الوصول الحر: | https://doaj.org/article/e00d86bc59fd4fb0a305dd039576982eTest |
| رقم الانضمام: | edsdoj.00d86bc59fd4fb0a305dd039576982e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 18196446 22253653 |
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| DOI: | 10.1234/1819-6446-2013-2-152-157 |