دورية أكاديمية
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification. ...
| العنوان: | Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification. ... |
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| المؤلفون: | Ho, Peh Joo, Ho, Weang Kee, Khng, Alexis J, Yeoh, Yen Shing, Tan, Benita Kiat-Tee, Tan, Ern Yu, Lim, Geok Hoon, Tan, Su-Ming, Tan, Veronique Kiak Mien, Yip, Cheng-Har, Mohd-Taib, Nur-Aishah, Wong, Fuh Yong, Lim, Elaine Hsuen, Ngeow, Joanne, Chay, Wen Yee, Leong, Lester Chee Hao, Yong, Wei Sean, Seah, Chin Mui, Tang, Siau Wei, Ng, Celene Wei Qi, Yan, Zhiyan, Lee, Jung Ah, Rahmat, Kartini, Islam, Tania, Hassan, Tiara, Tai, Mei-Chee, Khor, Chiea Chuen, Yuan, Jian-Min, Koh, Woon-Puay, Sim, Xueling, Dunning, Alison M, Bolla, Manjeet K, Antoniou, Antonis C, Teo, Soo-Hwang, Li, Jingmei, Hartman, Mikael |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Breast cancer, Gail model, Polygenic risk score, Protein-truncating variants, Risk-based screening, Asian People, Breast Neoplasms, Female, Genetic Predisposition to Disease, Humans, Risk Assessment |
| الوصف: | BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS: In this case-only analysis involving 7600 Asian breast cancer patients diagnosed between age 30 and 75 years, we examined identification of high-risk patients based on positive family history, the Gail model 5-year absolute risk [5yAR] above 1.3%, breast cancer predisposition genes (protein-truncating variants [PTV] in ATM, BRCA1, BRCA2, CHEK2, PALB2, BARD1, RAD51C, RAD51D, or TP53), and polygenic risk score (PRS) 5yAR above 1.3%. RESULTS: Correlation between 5yAR (at age of diagnosis) predicted by PRS and the Gail model was low (r=0.27). Fifty-three percent of breast cancer patients (n=4041) were considered high risk by one or more classification criteria. Positive family history, PTV carriership, PRS, or the Gail model identified 1247 (16%), 385 (5%), 2774 (36%), and 1592 (21%) ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.17863/cam.84996 |
| الإتاحة: | https://doi.org/10.17863/cam.84996Test https://www.repository.cam.ac.uk/handle/1810/337587Test |
| حقوق: | open.access ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 ; http://purl.org/coar/access_right/c_abf2Test |
| رقم الانضمام: | edsbas.9F51291E |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/cam.84996 |
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