دورية أكاديمية
Integrative study of pandemic A/H1N1 influenza infections: design and methods of the CoPanFlu-France cohort.
| العنوان: | Integrative study of pandemic A/H1N1 influenza infections: design and methods of the CoPanFlu-France cohort. |
|---|---|
| المؤلفون: | Lapidus, Nathanael, de Lamballerie, Xavier, Salez, Nicolas, Setbon, Michel, Ferrari, Pascal, Delabre, Rosemary, Gougeon, Marie-Lise, Vely, Frédéric, Leruez-Ville, Marianne, Andreoletti, Laurent, Cauchemez, Simon, Boëlle, Pierre-Yves, Vivier, Eric, Abel, Laurent, Schwarzinger, Michaël, Legeas, Michèle, Le Cann, Pierre, Flahault, Antoine, Carrat, Fabrice |
| المساهمون: | Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Emergence des Pathologies Virales (EPV), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie, Assistance Publique - Hôpitaux de Marseille (APHM)-Pôle hospitalier de Microbiologie et Maladies Infectieuses, École des Hautes Études en Santé Publique EHESP (EHESP), Immunité Anti-virale, Biothérapie et Vaccins (IABV), Institut Pasteur Paris (IP), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Virologie Médicale et Moléculaire - EA 4684 (CardioVir), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Hôpital universitaire Robert Debré Reims (CHU Reims), Medical Research Council Centre for Outbreak Analysis and Modeling, Imperial College London-Department of Infectious Disease Epidemiology, CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratory of Human Genetics of Infectious Diseases, Rockefeller University New York -Rockefeller Branch, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was supported by the Institut de Microbiologie et Maladies Infectieuses (IMMI-AVIESAN), the Institut de Santé Publique (ISP-AVIESAN), the French Ministry of Health and Assistance Publique Hôpitaux de Paris - PHRC 2010 #AOM10199, the French Ministry of research and the Institut de Recherche en Sante Publique (IReSP - TGIR 2009). |
| المصدر: | ISSN: 1471-2458. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2012 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Influenza a virus H1N1 subtype, Cohort study, Risk factors, France, [SHS]Humanities and Social Sciences, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [QFIN]Quantitative Finance [q-fin] |
| الوصف: | International audience ; ABSTRACT: BACKGROUND: The risk of influenza infection depends on biological characteristics, individual or collective behaviors and the environmental context. The Cohorts for Pandemic Influenza (CoPanFlu) France study was set up in 2009 after the identification of the novel swine-origin A/H1N1 pandemic influenza virus. This cohort of 601 households (1450 subjects) representative for the general population aims at using an integrative approach to study the risk and characteristics of influenza infection as a complex combination of data collected from questionnaires regarding sociodemographic, medical, behavioral characteristics of subjects and indoor environment, biological samples or environmental databases. METHODS: Households were included between December 2009 and July 2010. The design of this study relies on systematic follow-up visits between influenza seasons and additional visits during influenza seasons, when an influenza-like illness is detected in a household via an active surveillance system. During systematic visits, a nurse collects individual and environmental data on questionnaires and obtains blood samples from all members of the household. When an influenza-like-illness is detected, a nurse visits the household three times during the 12 following days, and collects data on questionnaires regarding exposure and symptoms, and biological samples (including nasal swabs) from all subjects in the household. The end of the follow-up period is expected in fall 2012. DISCUSSION: The large amount of data collected throughout the follow-up will permit a multidisciplinary study of influenza infections. Additional data is being collected and analyzed in this ongoing cohort. The longitudinal analysis of these households will permit integrative analyses of complex phenomena such as individual, collective and environmental risk factors of infection, routes of transmission, or determinants of the immune response to infection or vaccination. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22676272; inserm-00730688; https://inserm.hal.science/inserm-00730688Test; https://inserm.hal.science/inserm-00730688/documentTest; https://inserm.hal.science/inserm-00730688/file/1471-2458-12-417.pdfTest; PUBMED: 22676272 |
| DOI: | 10.1186/1471-2458-12-417 |
| الإتاحة: | https://doi.org/10.1186/1471-2458-12-417Test https://inserm.hal.science/inserm-00730688Test https://inserm.hal.science/inserm-00730688/documentTest https://inserm.hal.science/inserm-00730688/file/1471-2458-12-417.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FF9C565E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1471-2458-12-417 |
|---|