المؤلفون: Erzurumluoglu, A. Mesut, Liu, Mengzhen, Jackson, Victoria E., Barnes, Daniel R., Datta, Gargi, Melbourne, Carl A., Young, Robin, Batini, Chiara, Surendran, Praveen, Jiang, Tao, Adnan, Sheikh Daud, Afaq, Saima, Agrawal, Arpana, Altmaier, Elisabeth, Antoniou, Antonis C., Asselbergs, Folkert W., Baumbach, Clemens, Bierut, Laura, Bertelsen, Sarah, Boehnke, Michael, Bots, Michiel L., Brazel, David M., Chambers, John C., Chang-Claude, Jenny, Chen, Chu, Corley, Janie, Chou, Yi-Ling, David, Sean P., de Boer, Rudolf A., de Leeuw, Christiaan A., Dennis, Joe G., Dominiczak, Anna F., Dunning, Alison M., Easton, Douglas F., Eaton, Charles, Elliott, Paul, Evangelou, Evangelos, Faul, Jessica D., Foroud, Tatiana, Goate, Alison, Gong, Jian, Grabe, Hans J., Haessler, Jeff, Haiman, Christopher, Hallmans, Goran, Hammerschlag, Anke R., Harris, Sarah E., Hattersley, Andrew, Heath, Andrew, Hsu, Chris, Iacono, William G., Kanoni, Stavroula, Kapoor, Manav, Kaprio, Jaakko, Kardia, Sharon L., Karpe, Fredrik, Kontto, Jukka, Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Laakso, Markku, Lai, Dongbing, Langenberg, Claudia, Le, Nhung, Lettre, Guillaume, Loukola, Anu, Luan, Jian'an, Madden, Pamela A. F., Mangino, Massimo, Marioni, Riccardo E., Marouli, Eirini, Marten, Jonathan, Martin, Nicholas G., McGue, Matt, Michailidou, Kyriaki, Mihailov, Evelin, Moayyeri, Alireza, Moitry, Marie, Mueller-Nurasyid, Martina, Naheed, Aliya, Nauck, Matthias, Neville, Matthew J., Nielsen, Sune Fallgaard, North, Kari, Perola, Markus, Pharoah, Paul D. P., Pistis, Giorgio, Polderman, Tinca J., Posthuma, Danielle, Poulter, Neil, Qaiser, Beenish, Rasheed, Asif, Reiner, Alex, Renstrom, Frida, Rice, John, Rohde, Rebecca, Rolandsson, Olov, Samani, Nilesh J., Samuel, Maria, Schlessinger, David, Scholte, Steven H., Scott, Robert A., Sever, Peter, Shao, Yaming, Shrine, Nick, Smith, Jennifer A., Starr, John M., Stirrups, Kathleen, Stram, Danielle, Stringham, Heather M., Tachmazidou, Ioanna, Tardif, Jean-Claude, Thompson, Deborah J., Tindle, Hilary A., Tragante, Vinicius, Trompet, Stella, Turcot, Valerie, Tyrrell, Jessica, Vaartjes, Ilonca, van der Leij, Andries R., van der Meer, Peter, Varga, Tibor V., Verweij, Niek, Voelzke, Henry, Wareham, Nicholas J., Warren, Helen R., Weir, David R., Weiss, Stefan, Wetherill, Leah, Yaghootkar, Hanieh, Yavas, Ersin, Jiang, Yu, Chen, Fang, Zhan, Xiaowei, Zhang, Weihua, Zhao, Wei, Zhou, Kaixin, Amouyel, Philippe, Blankenberg, Stefan, Caulfield, Mark J., Chowdhury, Rajiv, Cucca, Francesco, Deary, Ian J., Deloukas, Panos, Di Angelantonio, Emanuele, Ferrario, Marco, Ferrieres, Jean, Franks, Paul W., Frayling, Tim M., Frossard, Philippe, Hall, Ian P., Hayward, Caroline, Jansson, Jan-Hakan, Jukema, J. Wouter, Kee, Frank, Männistö, Satu, Metspalu, Andres, Munroe, Patricia B., Nordestgaard, Borge Gronne, Palmer, Colin N. A., Salomaa, Veikko, Sattar, Naveed, Spector, Timothy, Strachan, David Peter, van der Harst, Pim, Zeggini, Eleftheria, Saleheen, Danish, Butterworth, Adam S., Wain, Louise V., Abecasis, Goncalo R., Danesh, John, Tobin, Martin D., Vrieze, Scott, Liu, Dajiang J., Howson, Joanna M. M.

المساهمون: Institute for Molecular Medicine Finland, Department of Public Health, University of Helsinki, HUSLAB

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, LD SCORE REGRESSION, MENDELIAN RANDOMIZATION, LUNG-CANCER, BIOLOGICAL INSIGHTS, CIGARETTE-SMOKING, DISEASE, EFFICIENT, RISK, DATABASE, Biochemistry, cell and molecular biology, Neurosciences, Neurology and psychiatry

وصف الملف: application/pdf

العلاقة: Erzurumluoglu , A M , Liu , M , Jackson , V E , Barnes , D R , Datta , G , Melbourne , C A , Young , R , Batini , C , Surendran , P , Jiang , T , Adnan , S D , Afaq , S , Agrawal , A , Altmaier , E , Antoniou , A C , Asselbergs , F W , Baumbach , C , Bierut , L , Bertelsen , S , Boehnke , M , Bots , M L , Brazel , D M , Chambers , J C , Chang-Claude , J , Chen , C , Corley , J , Chou , Y-L , David , S P , de Boer , R A , de Leeuw , C A , Dennis , J G , Dominiczak , A F , Dunning , A M , Easton , D F , Eaton , C , Elliott , P , Evangelou , E , Faul , J D , Foroud , T , Goate , A , Gong , J , Grabe , H J , Haessler , J , Haiman , C , Hallmans , G , Hammerschlag , A R , Harris , S E , Hattersley , A , Heath , A , Hsu , C , Iacono , W G , Kanoni , S , Kapoor , M , Kaprio , J , Kardia , S L , Karpe , F , Kontto , J , Kooner , J S , Kooperberg , C , Kuulasmaa , K , Laakso , M , Lai , D , Langenberg , C , Le , N , Lettre , G , Loukola , A , Luan , J , Madden , P A F , Mangino , M , Marioni , R E , Marouli , E , Marten , J , Martin , N G , McGue , M , Michailidou , K , Mihailov , E , Moayyeri , A , Moitry , M , Mueller-Nurasyid , M , Naheed , A , Nauck , M , Neville , M J , Nielsen , S F , North , K , Perola , M , Pharoah , P D P , Pistis , G , Polderman , T J , Posthuma , D , Poulter , N , Qaiser , B , Rasheed , A , Reiner , A , Renstrom , F , Rice , J , Rohde , R , Rolandsson , O , Samani , N J , Samuel , M , Schlessinger , D , Scholte , S H , Scott , R A , Sever , P , Shao , Y , Shrine , N , Smith , J A , Starr , J M , Stirrups , K , Stram , D , Stringham , H M , Tachmazidou , I , Tardif , J-C , Thompson , D J , Tindle , H A , Tragante , V , Trompet , S , Turcot , V , Tyrrell , J , Vaartjes , I , van der Leij , A R , van der Meer , P , Varga , T V , Verweij , N , Voelzke , H , Wareham , N J , Warren , H R , Weir , D R , Weiss , S , Wetherill , L , Yaghootkar , H , Yavas , E , Jiang , Y , Chen , F , Zhan , X , Zhang , W , Zhao , W , Zhao , W , Zhou , K , Amouyel , P , Blankenberg , S , Caulfield , M J , Chowdhury , R , Cucca , F , Deary , I J , Deloukas , P , Di Angelantonio , E , Ferrario , M , Ferrieres , J , Franks , P W , Frayling , T M , Frossard , P , Hall , I P , Hayward , C , Jansson , J-H , Jukema , J W , Kee , F , Männistö , S , Metspalu , A , Munroe , P B , Nordestgaard , B G , Palmer , C N A , Salomaa , V , Sattar , N , Spector , T , Strachan , D P , van der Harst , P , Zeggini , E , Saleheen , D , Butterworth , A S , Wain , L V , Abecasis , G R , Danesh , J , Tobin , M D , Vrieze , S , Liu , D J & Howson , J M M 2020 , ' Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci ' , Molecular Psychiatry , vol. 25 , no. 10 , pp. 2392-2409 . https://doi.org/10.1038/s41380-018-0313-0Test; ORCID: /0000-0003-0542-5967/work/82467109; ORCID: /0000-0002-3716-2455/work/82465282; http://hdl.handle.net/10138/320420Test; 0595ca3c-2d44-4572-835b-d068fe7ad554; 000572540100017

الإتاحة: http://hdl.handle.net/10138/320420Test

المؤلفون: Aschard, Hugues, Tobin, Martin D., Hancock, Dana B., Skurnik, David, Sood, Akshay, James, Alan, Smith, Albert Vernon, Manichaikul, Aniw, Campbell, Archie, Prins, Bram P., Hayward, Caroline, Loth, Daanw, Porteous, David J., Strachan, David P., Zeggini, Eleftheria, O'Connor, George T., Brusselle, Guy G., Boezen, H. Marike, Schulz, Holger, Deary, Ian J., Hall, Ian P., Rudan, Igor, Kaprio, Jaakko, Wilson, James F., Wilk, Jemma B., Huffman, Jennifer E., Zhao, Jing Hua, de Jong, Kim, Lyytikainen, Leo-Pekka, Wain, Louise V., Jarvelin, Marjo-Riitta, Kahonen, Mika, Fornage, Myriam, Polasek, Ozren, Cassano, Patricia A., Barr, R. Graham, Rawal, Rajesh, Harris, Sarah E., Gharib, Sina A., Enroth, Stefan, Heckbert, Susan R., Lehtimaki, Terho, Gyllensten, Ulf, Jackson, Victoria E., Gudnason, Vilmundur, Tang, Wenbo, Dupuis, Josee, Artigas, Maria Soler, Joshi, Amit D., London, Stephanie J., Understanding Soc Sci Grp

المساهمون: Clinicum, Institute for Molecular Medicine Finland, Department of Public Health, University of Helsinki, Genetic Epidemiology

مصطلحات موضوعية: FEV1/FVC, smoking, gene-environment interaction, genetic risk score, GENOME-WIDE ASSOCIATION, ENVIRONMENT INTERACTIONS, LUNG-FUNCTION, RISK, EPIDEMIOLOGY, OPPORTUNITIES, OBSTRUCTION, PREDICTION, DISEASE, 3142 Public health care science, environmental and occupational health

وصف الملف: application/pdf

العلاقة: We thank the many colleagues who contributed to collection and phenotypic characterization of the clinical sampling and genotyping of the data. We especially thank those who kindly agreed to participate in the studies. H.A. was supported by R21HG007687. S.J.L. was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. The research undertaken by M.D.T., L.V.W. was partly funded by the National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. A full list of studies and authors source of funding source and acknowledgements is provided in the Supplementary data. H.A., P.K., S.J.L., M.T., D.B.H. and A.J. were involved in designing the study. M.D.T., D.B.H., A.S., A.J., A.V.S., A.W.M., D.W.L., D.P.S., G.O.C., R.G.B., G.G.B., I.P.H., J.K.P., J.F.W., J.W., J.H.Z., K.d.J., L.V.W., M.S. ., H.M.B., M-R.J., M.F., P.A.C., S.A.G., S.R.H., V.G., W.T., S.J.L., I.R., O.P., J.E.H., C.H., A.C., D.J.P., S.E.H., I.J.D., S.E., U.G., LP.L., T.L., E.Z., B.P.P. and V.E.J. were involved in participant recruitment, sample collection or genotyping. H.A. performed analyses from the discovery study. H.A., V.E.J. and M.S.A. performed the replication analysis. H.A. drafted the paper, with substantial editorial input from P.K., S.J.L., J.D., D.S., M.T., D.B.H. and A.J. All authors have reviewed and approved the final draft. This material has not been published previously in a substantively similar form.; Aschard , H , Tobin , M D , Hancock , D B , Skurnik , D , Sood , A , James , A , Smith , A V , Manichaikul , A , Campbell , A , Prins , B P , Hayward , C , Loth , D , Porteous , D J , Strachan , D P , Zeggini , E , O'Connor , G T , Brusselle , G G , Boezen , H M , Schulz , H , Deary , I J , Hall , I P , Rudan , I , Kaprio , J , Wilson , J F , Wilk , J B , Huffman , J E , Zhao , J H , de Jong , K , Lyytikainen , L-P , Wain , L V , Jarvelin , M-R , Kahonen , M , Fornage , M , Polasek , O , Cassano , P A , Barr , R G , Rawal , R , Harris , S E , Gharib , S A , Enroth , S , Heckbert , S R , Lehtimaki , T , Gyllensten , U , Jackson , V E , Gudnason , V , Tang , W , Dupuis , J , Artigas , M S , Joshi , A D , London , S J & Understanding Soc Sci Grp 2017 , ' Evidence for large-scale gene-by-smoking interaction effects on pulmonary function ' , International Journal of Epidemiology , vol. 46 , no. 3 , pp. 894-904 . https://doi.org/10.1093/ije/dyw318Test; 85027726305; 9e7597ad-e98b-4f30-8d4c-7d7f11f0e355; http://hdl.handle.net/10138/211830Test; 000406242600023

الإتاحة: http://hdl.handle.net/10138/211830Test

المؤلفون: Erzurumluoglu, A Mesut, Liu, Mengzhen, Jackson, Victoria E, Barnes, Daniel R, Datta, Gargi, Melbourne, Carl A, Young, Robin, Batini, Chiara, Surendran, Praveen, Jiang, Tao, Adnan, Sheikh Daud, Afaq, Saima, Agrawal, Arpana, Altmaier, Elisabeth, Antoniou, Antonis C, Asselbergs, Folkert W, Baumbach, Clemens, Bierut, Laura, Bertelsen, Sarah, Boehnke, Michael, Bots, Michiel L, Brazel, David M, Chambers, John C, Chang-Claude, Jenny, Chen, Chu, Corley, Janie, Chou, Yi-Ling, David, Sean P, de Boer, Rudolf A, de Leeuw, Christiaan A, Dennis, Joe G, Dominiczak, Anna F, Dunning, Alison M, Easton, Douglas F, Eaton, Charles, Elliott, Paul, Evangelou, Evangelos, Faul, Jessica D, Foroud, Tatiana, Goate, Alison, Gong, Jian, Grabe, Hans J, Haessler, Jeff, Haiman, Christopher, Hallmans, Göran, Karpe, Fredrik, Nielsen, Sune Fallgaard, Varga, Tibor V, Chen, Fang, Nordestgaard, Børge Grønne

المساهمون: Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)

المصدر: Molecular Psychiatry, 25(10), 2392-2409. Nature Publishing Group
Erzurumluoglu, A M, Liu, M, Jackson, V E, Barnes, D R, Datta, G, Melbourne, C A, Young, R, Batini, C, Surendran, P, Jiang, T, Adnan, S D, Afaq, S, Agrawal, A, Altmaier, E, Antoniou, A C, Asselbergs, F W, Baumbach, C, Bierut, L, Bertelsen, S, Boehnke, M, Bots, M L, Brazel, D M, Chambers, J C, Chang-Claude, J, Chen, C, Corley, J, Chou, Y-L, David, S P, de Boer, R A, de Leeuw, C A, Dennis, J G, Dominiczak, A F, Dunning, A M, Easton, D F, Eaton, C, Elliott, P, Evangelou, E, Faul, J D, Foroud, T, Goate, A, Gong, J, Grabe, H J, Haessler, J, Haiman, C, Hallmans, G, Karpe, F, Nielsen, S F, Varga, T V, Chen, F, Nordestgaard, B G & Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium 2020, ' Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci ', Molecular Psychiatry, pp. 2392-2409 . https://doi.org/10.1038/s41380-018-0313-0Test

مصطلحات موضوعية: RISK, LUNG-CANCER, DATABASE, LD SCORE REGRESSION, BIOLOGICAL INSIGHTS, MENDELIAN RANDOMIZATION, EFFICIENT, CIGARETTE-SMOKING, GENOME-WIDE ASSOCIATION, DISEASE

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::53237f1cd32abbc23a7095253a03810cTest
https://research.rug.nl/en/publications/e2a692b0-a9b4-4117-a444-1c18f5dfa2f6Test