دورية أكاديمية
Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study)
| العنوان: | Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) |
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| المؤلفون: | Lluís, Núria, Serradilla-Martín, Mario, Achalandabaso, Mar, Jehaes, François, Dasari, Bobby V. M., Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J. H., Amaral, Maria J., Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, López-López, Víctor, Alsammani, Mohammedsuror, Detry, Olivier, Domingo-Del Pozo, Carlos, Machairas, Nikolaos, Pekli, Damján, Alcázar-López, Cándido F., Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Díez-Caballero, Alberto, Francart, David, Noel, Colin B., Sousa-Silva, Donzília, Toledo-Martínez, Enrique, Tzimas, George N., Yaqub, Sheraz, Cauchy, François, Prieto-Calvo, Mikel, D'Souza, Melroy A., Spiers, Harry V. M., van den Heuvel, Marius C., Charco, Ramón, Lesurtel, Mickaël, Ramia, José M. |
| بيانات النشر: | Wolters Kluwer Health |
| سنة النشر: | 2023 |
| المجموعة: | Universidade de Coimbra: Estudo Geral |
| مصطلحات موضوعية: | bile duct neoplasms, intraductal precursor lesion, pancreas, surgical resection, textbook outcome, Humans, Female, Aged, Male, Bile Ducts, Intrahepatic, Retrospective Studies, Carcinoma, Papillary |
| الوصف: | Background/Purpose: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers. Methods: A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between 1 January 2010 and 31 December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association. The textbook outcome (TO) was defined as a non-prolonged length of hospital stay plus the absence of any Clavien–Dindo grade at least III complications, readmission, or mortality within 90 postoperative days. Results: A total of 28 centers contributed 85 patients who underwent surgery for IPNB. The median age was 66 years (55–72), 49.4% were women, and 87.1% were Caucasian. Open surgery was performed in 72 patients (84.7%) and laparoscopic in 13 (15.3%). TO was achieved in 54.1% of patients, reaching 63.8% after liver resection and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI: 50–82). Overall survival was better in patients with Charlson comorbidity score 4 or less versus more than 4 (P =0.016), intrahepatic versus extrahepatic tumor (P=0.027), single versus multiple tumors (P= 0.007), those who underwent hepatic versus pancreatic resection (P= 0.017), or achieved versus failed TO (P=0.029). Multivariable Cox regression analysis showed that not achieving TO (HR: 4.20; 95% CI: 1.11–15.94; P=0.03) was an independent prognostic factor of poor overall survival. Conclusions: Patients undergoing liver resection for IPNB were more likely to achieve a TO outcome than those requiring a pancreatic resection. Comorbidity, tumor location, and tumor multiplicity influenced overall survival. TO was an independent prognostic factor of overall survival. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1743-9159 |
| العلاقة: | https://hdl.handle.net/10316/113490Test |
| DOI: | 10.1097/JS9.0000000000000280 |
| الإتاحة: | https://doi.org/10.1097/JS9.0000000000000280Test https://hdl.handle.net/10316/113490Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FB9ED47D |
| قاعدة البيانات: | BASE |
| تدمد: | 17439159 |
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| DOI: | 10.1097/JS9.0000000000000280 |