التفاصيل البيبلوغرافية
| العنوان: |
Renal Replacement Therapy in Patients with Severe Precapillary Pulmonary Hypertension with Acute Right Heart Failure. |
| المؤلفون: |
Sztrymf, Benjamin, Prat, Dominique1,2, Jacobs, Frédéric M.1,2,3, Brivet, François G.1,2,3, O'Callaghan, Dermot S.4,5, Price, Laura C.4, Jais, Xavier3,4,5, Sitbon, Olivier3,4,5, Simonneau, Gérald3,4,5, Humbert, Marc3,4,5 |
| المصدر: |
Respiration. May2013, Vol. 85 Issue 6, p464-470. 7p. 4 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*HEART failure treatment, *PULMONARY hypertension, *THERAPEUTICS, *HEART ventricle diseases, *CHI-squared test, *RIGHT heart ventricle, *KIDNEY diseases, *SURVIVAL analysis (Biometry), *U-statistics, *RETROSPECTIVE studies, *DATA analysis software, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator, *PROGNOSIS |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Background: Renal replacement therapy has been suggested as a therapeutic option in the setting of acute right ventricular failure in patients with severe precapillary pulmonary hypertension. However, there are few data supporting this strategy. Objectives: To describe the clinical course and the prognosis of pulmonary hypertensive patients undergoing renal replacement therapy in the setting of acute right heart failure. Methods: This was a single-center retrospective study over an 11-year period. Data were collected from all patients with chronic precapillary pulmonary hypertension requiring catecholamine infusions for clinical worsening and acute kidney injury that necessitated renal replacement therapy. Results: Fourteen patients were included. At admission, patients had a blood urea of 28.2 mmol/l (22.3-41.2), a creatinine level of 496 μmol/l (304-590), and a mean urine output in the 24 h preceding hospitalization of 200 ml (0-650). Sixty-eight renal replacement therapy sessions were performed, 36 of which were continuous and 32 of which were intermittent. Systemic hypotension occurred in 16/32 intermittent and 16/36 continuous sessions (p = 0.9). Two patients died during a continuous session. The intensive care unit-related, 1-, and 3-month mortality was 46.7, 66.7, and 73.3%, respectively. Conclusion: Renal replacement therapy is feasible in the setting of acute right ventricular failure in patients with severe precapillary pulmonary hypertension but is associated with a poor prognosis. The best modality and timing in this population remain to be defined. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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