دورية أكاديمية
Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‐on First Italian netwoRk Study (BRIVAFIRST)
| العنوان: | Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‐on First Italian netwoRk Study (BRIVAFIRST) |
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| المؤلفون: | Simona Lattanzi 1, Michele Ascoli 2, Laura Canafoglia 3, Maria Paola Canevini 4 5, Sara Casciato 6, Emanuele Cerulli Irelli 7, Valentina Chiesa 4, Filippo Dainese 8, Giovanni De Maria 9, Giuseppe Didato 10, Giancarlo Di Gennaro 6, Giovanni Falcicchio 11, Martina Fanella 7, Massimo Gangitano 12, Angela La Neve 11, Oriano Mecarelli 7, Elisa Montalenti 13, Alessandra Morano 7, Federico Piazza 14, Chiara Pizzanelli 15, Patrizia Pulitano 7, Federica Ranzato 16, Eleonora Rosati 17, Laura Tassi 18, Carlo Di Bonaventura 7, BRIVAFIRST Group Collaborators, Affiliations collapse Collaborators BRIVAFIRST Group: Angela Alicino, Giovanni Assenza, Federica Avorio, Valeria Badioni, Paola Banfi, Emanuele Bartolini, Luca Manfredi Basili, Vincenzo Belcastro, Simone Beretta, Irene Berto, Martina Biggi, Giuseppe Billo, Giovanni Boero, Paolo Bonanni, Jole Bongiorno, Francesco Brigo, Emanuele Caggia, Claudia Cagnetti, Carmen Calvello, Edward Cesnik, Gigliola Chianale, Domenico Ciampanelli, Roberta Ciuffini, Dario Cocito, Donato Colella, Margerita Contento, Cinzia Costa, Eduardo Cumbo, Alfredo D'Aniello, Francesco Deleo, Jacopo C DiFrancesco, Roberta Di Giacomo, Alessandra Di Liberto, Elisabetta Domina, Francesco Donato, Fedele Dono, Vania Durante, Maurizio Elia, Anna Estraneo, Giacomo Evangelista, Maria Teresa Faedda, Ylenia Failli, Elisa Fallica, Jinane Fattouch, Alessandra Ferrari, Florinda Ferreri, Giacomo Fisco, Davide Fonti, Francesco Fortunato, Nicoletta Foschi, Teresa Francavilla, Rosita Galli, Sara Gasparini, Stefano Gazzina, Anna Teresa Giallonardo, Filippo Sean Giorgi, Loretta Giuliano, Francesco Habetswallner, Francesca Izzi, Benedetta Kassabian, Lorenzo Kiferle, Angelo Labate, Concetta Luisi, Matteo Magliani, Giulia Maira, Luisa Mari, Daniela Marino, Addolorata Mascia, Alessandra Mazzeo, Stefano Meletti, Chiara Milano, Annacarmen Nilo, Biagio Orlando, Francesco Paladin, Maria Grazia Pascarella, Chiara Pastori, Giada Pauletto, Alessia Peretti, Gabriella Perri, Marianna Pezzella, Marta Piccioli, Pietro Pignatta, Nicola Pilolli, Francesco Pisani, Laura Rosa Pisani, Fabio Placidi, Patrizia Pollicino, Vittoria Porcella, Monica Puligheddu, Stefano Quadri, Pier Paolo Quarato, Rui Quintas, Rosaria Renna, Adriana Rum, Enrico Michele Salamone, Ersilia Savastano, Maria Sessa, David Stokelj, Elena Tartara, Mario Tombini, Gemma Tumminelli, Anna Elisabetta Vaudano, Ilaria Viganò, Emanuela Viglietta, Aglaia Vignoli, Flavio Villani, Elena Zambrelli, Lelia Zummo |
| المساهمون: | 1, Simona Lattanzi, 2, Michele Ascoli, 3, Laura Canafoglia, 4 5, Maria Paola Canevini, 6, Sara Casciato, 7, Emanuele Cerulli Irelli, 4, Valentina Chiesa, 8, Filippo Dainese, 9, Giovanni De Maria, Didato 10, Giuseppe, 6, Giancarlo Di Gennaro, Falcicchio 11, Giovanni, 7, Martina Fanella, Gangitano 12, Massimo, La Neve 11, Angela, 7, Oriano Mecarelli, Montalenti 13, Elisa, 7, Alessandra Morano, Piazza 14, Federico, Pizzanelli 15, Chiara, 7, Patrizia Pulitano, Ranzato 16, Federica, Rosati 17, Eleonora, Tassi 18, Laura, 7, Carlo Di Bonaventura, Group Collaborators, Brivafirst, collapse Collaborators BRIVAFIRST Group: Angela Alicino, Affiliation, Assenza, Giovanni, Avorio, Federica, Badioni, Valeria, Banfi, Paola, Bartolini, Emanuele, Manfredi Basili, Luca, Belcastro, Vincenzo, Beretta, Simone, Berto, Irene, Biggi, Martina, Billo, Giuseppe, Boero, Giovanni, Bonanni, Paolo, Bongiorno, Jole, Brigo, Francesco, Caggia, Emanuele, Cagnetti, Claudia, Calvello, Carmen, Cesnik, Edward, Chianale, Gigliola, Ciampanelli, Domenico, Ciuffini, Roberta, Cocito, Dario, Colella, Donato, Contento, Margerita, Costa, Cinzia, Cumbo, Eduardo, D'Aniello, Alfredo, Deleo, Francesco, C DiFrancesco, Jacopo, Di Giacomo, Roberta, Di Liberto, Alessandra, Domina, Elisabetta, Donato, Francesco, Dono, Fedele, Durante, Vania, Elia, Maurizio, Estraneo, Anna, Evangelista, Giacomo, Teresa Faedda, Maria, Failli, Ylenia, Fallica, Elisa, Fattouch, Jinane, Ferrari, Alessandra, Ferreri, Florinda, Fisco, Giacomo, Fonti, Davide, Fortunato, Francesco, Foschi, Nicoletta, Francavilla, Teresa, Galli, Rosita, Gasparini, Sara, Gazzina, Stefano, Teresa Giallonardo, Anna, Sean Giorgi, Filippo, Giuliano, Loretta, Habetswallner, Francesco, Izzi, Francesca, Kassabian, Benedetta, Kiferle, Lorenzo, Labate, Angelo, Luisi, Concetta, Magliani, Matteo, Maira, Giulia, Mari, Luisa, Marino, Daniela, Mascia, Addolorata, Mazzeo, Alessandra, Meletti, Stefano, Milano, Chiara, Nilo, Annacarmen, Orlando, Biagio, Paladin, Francesco |
| بيانات النشر: | NLM (Medline) |
| سنة النشر: | 2022 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Aged, Double-Blind Method, Drug Therapy, Combination, Human, Italy, Pyrrolidinone, Retrospective Studie, Seizure, Treatment Outcome, Anticonvulsant, Epilepsy |
| الوصف: | BACKGROUND: The management of epilepsy in older adults has become part of daily practice because of an aging population. Older patients with epilepsy represent a distinct and more vulnerable clinical group as compared with younger patients, and they are generally under-represented in randomized placebo-controlled trials. Real-world studies can therefore be a useful complement to characterize the drug's profile. Brivaracetam is a rationally developed compound characterized by high-affinity binding to synaptic vesicle protein 2A and approved as adjunctive therapy for focal seizures in adults with epilepsy. OBJECTIVE: The aim of this study was to assess the 12-month effectiveness and tolerability of adjunctive brivaracetam in older patients (≥65 years of age) with epilepsy treated in a real-world setting. METHODS: The BRIVAFIRST (BRIVAracetam add-on First Italian netwoRk STudy) was a 12-month retrospective multicenter study including adult patients prescribed adjunctive brivaracetam. Effectiveness outcomes included the rates of seizure response (≥50% reduction in baseline seizure frequency), seizure freedom, and treatment discontinuation. Safety and tolerability outcomes included the rate of treatment discontinuation due to adverse events and the incidence of adverse events. Data were compared for patients aged ≥65 years of age ('older') vs those aged <65 years ('younger'). RESULTS: There were 1029 patients with focal epilepsy included in the study, of whom 111 (10.8%) were aged ≥65 years. The median daily dose of brivaracetam at 3 months was 100 [interquartile range, 100-175] mg in the older group and 100 [100-200] mg in the younger group (p = 0.036); it was 150 [100-200] mg in both groups either at 6 months (p = 0.095) or 12 months (p = 0.140). At 12 months, 49 (44.1%) older and 334 (36.4%) younger patients had a reduction in their baseline seizure frequency by at least 50% (p = 0.110), and the seizure freedom rates were 35/111 (31.5%) and 134/918 (14.6%) in older and younger groups, respectively (p < ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35344198; info:eu-repo/semantics/altIdentifier/wos/WOS:000773857800001; volume:39; issue:4; firstpage:297; lastpage:304; numberofpages:8; journal:DRUGS & AGING; http://hdl.handle.net/11577/3447526Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85128488067 |
| DOI: | 10.1007/s40266-022-00931-4 |
| الإتاحة: | https://doi.org/10.1007/s40266-022-00931-4Test http://hdl.handle.net/11577/3447526Test |
| رقم الانضمام: | edsbas.2D4B608C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s40266-022-00931-4 |
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