Improved perioperative outcomes and reduced inflammatory stress response in malignant robot-assisted colorectal resections: a retrospective cohort study of 298 patients
| العنوان: | Improved perioperative outcomes and reduced inflammatory stress response in malignant robot-assisted colorectal resections: a retrospective cohort study of 298 patients |
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| المؤلفون: | Andreas Kristian Pedersen, Christian Backer Mogensen, Randi Maria Simonsen, Per Helligsø, Mark Bremholm Ellebæk, Mirjana Komljen, Michael Festersen Nielsen, Pedja Cuk |
| المصدر: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-11 (2021) Cuk, P, Simonsen, R M, Komljen, M, Nielsen, M F, Helligsø, P, Pedersen, A K, Mogensen, C B & Ellebæk, M B 2021, ' Improved perioperative outcomes and reduced inflammatory stress response in malignant robot-assisted colorectal resections : a retrospective cohort study of 298 patients ', World Journal of Surgical Oncology, vol. 19, 155 . https://doi.org/10.1186/s12957-021-02263-wTest |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Laparoscopic surgery, medicine.medical_specialty, RD1-811, Colorectal cancer, medicine.medical_treatment, Robot-assisted colorectal surgery, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Robotic Surgical Procedures, Interquartile range, Minimally invasive surgery, medicine, Humans, Robotic surgery, Prospective Studies, Prospective cohort study, Robotic Surgical Procedures/adverse effects, RC254-282, Retrospective Studies, business.industry, Research, Malignant Colorectal Neoplasm, Postoperative inflammatory stress response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Retrospective cohort study, Perioperative, Robotics, medicine.disease, Prognosis, Colorectal Neoplasms/surgery, Surgery, Treatment Outcome, Oncology, Laparoscopic colorectal surgery, 030220 oncology & carcinogenesis, Surgical oncology, 030211 gastroenterology & hepatology, Laparoscopy, business, Colorectal Neoplasms |
| الوصف: | Background Robot-assisted surgery is increasingly implemented for the resection of colorectal cancer, although the scientific evidence for adopting this technique is still limited. This study’s main objective was to compare short-term complication rates, oncological outcomes, and the inflammatory stress response after colorectal resection for cancer performed laparoscopic or robot-assisted. Methods We conducted a retrospective cohort study comparing the robot-assisted approach to laparoscopic surgery for elective malignant colorectal neoplasm. Certified colorectal and da Vinci ® robotic surgeons performed resections at a Danish tertiary colorectal high volume center from May 2017 to March 2019. We analyzed the two surgical groups using uni- and multivariate regression analyses to detect differences in intra- and postoperative clinical outcomes and the inflammatory stress response. Results Two hundred and ninety-eight patients were enrolled in the study. Significant differences favoring robot-assisted surgery was demonstrated for; length of hospital stay (4 days, interquartile range (4, 5) versus 5 days, interquartile range (4–7), p < 0.001), and intraoperative blood loss (50 mL, interquartile range (20–100) versus 100 mL, interquartile range (50–150), p < 0.001) compared to laparoscopic surgery. The inflammatory stress response was significantly higher after laparoscopic compared to robot-assisted surgery reflected by an increase in C-reactive protein concentration (exponentiated coefficient = 1.23, 95% confidence interval (1.06–1.46), p = 0.008). No differences between the two groups were found concerning mortality, microradical resection rate, conversion to open surgery, and surgical or medical short-term complication rates. Conclusion Robot-assisted surgery is feasible and can be safely implemented for colorectal resections. The robot-assisted approach, when compared to laparoscopic surgery, was associated with improved intra- and postoperative outcomes. Extensive prospective studies are needed to determine the short- and long-term outcomes of robotic surgery for colorectal cancer. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1477-7819 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d703c852f41205ce9c6f3069635c994Test http://europepmc.org/articles/PMC8141231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d703c852f41205ce9c6f3069635c994 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14777819 |
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