دورية أكاديمية
Comparison of response evaluation criteria in solid tumours and choi criteria for response evaluation in patients with advanced soft tissue sarcoma treated with trabectedin: a retrospective analysis
| العنوان: | Comparison of response evaluation criteria in solid tumours and choi criteria for response evaluation in patients with advanced soft tissue sarcoma treated with trabectedin: a retrospective analysis |
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| المؤلفون: | Taieb, Sophie, Saada-Bouzid, Esma, Tresch-Bruneel, Emmanuelle, Ryckewaert, Thomas, Bompas, Emmanuelle, Italiano, Antoine, Guillemet, Cécile, Peugniez, Charlotte, Piperno-Neumann, Sophie, Thyss, Antoine, Maynou, Carlos, Clisant-Delaine, Stephanie, Penel, Nicolas |
| المساهمون: | CHU Lille, Université de Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 METRICS, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Santé publique : épidémiologie et qualité des soins - EA 2694 |
| سنة النشر: | 2015 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Trabectedin, Sarcoma, Response assessment |
| الوصف: | BACKGROUND: To assess the additional value of density measurement using contrast-enhancement sequences (Choi assessment) in a real-life cohort of adult soft tissue sarcoma patients treated with trabectedin. METHODS: Eligibility criteria included adults (age ⩾18) treated between 01/2007 and 12/2011, with at least two trabectedin cycles after failure or intolerance to doxorubicin/ifosfamide. Baseline and first computed tomography (CT)-scans were centrally reviewed by an experienced radiologist. RESULTS: The retrospective cohort consists of 134 (73 female) patients treated with trabectedin 1.5 mg/m(2) given as a 24-h infusion every 3 weeks. Patients received a median of five trabectedin cycles (range: 2-33) and the main cause of discontinuation was progressive disease (PD) (n = 105, 78.4%). Response Evaluation Criteria in Solid Tumours (RECIST) assessment was feasible in 128 (95.5%) patients, with Choi assessment performed in 92 (68.7%) patients, generally due to inadequate sequences or exclusive lung metastases. Concordance between both methods was fair (Kappa = 0.290). We identified five patients with false PD (i.e. PD according to RECIST but stable disease/partial response as per Choi). Univariate analysis did not identify any predictive factors for false PD. Median overall survival (OS) of patients with PD as per RECIST but stable disease/partial response (SD/PR) according to Choi was better than for patients with PD according to both RECIST and Choi (14 months versus 8 months; p = 0.052). CONCLUSIONS: Choi assessment may identify patients with false PD who achieved improved efficacy outcomes, suggesting that trabectedin may delay tumour progression even in the case of non-dimensional response. Dual size and tumour density assessment may be more suitable to evaluate responses to trabectedin in sarcoma patients as well as to improve the decision-making strategies for the continuation of trabectedin therapy. ; 51 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | European journal of cancer (Oxford, England . 1990); Eur. J. Cancer; http://hdl.handle.net/20.500.12210/17096Test |
| الإتاحة: | https://doi.org/20.500.12210/17096Test https://hdl.handle.net/20.500.12210/17096Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.2FF25CB5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |