دورية أكاديمية
Clinical and molecular features of virus-induced acute exacerbations of chronic obstructive pulmonary diseas ; Клинико-молекулярные особенности вирус-ассоциированных обострений хронической обструктивной болезни легких
| العنوان: | Clinical and molecular features of virus-induced acute exacerbations of chronic obstructive pulmonary diseas ; Клинико-молекулярные особенности вирус-ассоциированных обострений хронической обструктивной болезни легких |
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| المؤلفون: | L. A. Shpagina, O. S. Kotova, I. S. Shpagin, D. A. Gerasimenko, G. V. Kuznetsova, S. A. Karmanovskaya, E. M. Loktin, A. A. Rukavitsyna, E. V. Anikina, N. V. Kamneva, K. V. Likhenko-Logvinenko, Л. А. Шпагина, О. С. Котова, И. С. Шпагин, Д. А. Герасименко, Г. В. Кузнецова, С. А. Кармановская, Е. М. Локтин, А. А. Рукавицына, Е. В. Аникина, Н. В. Камнева, К. В. Лихенко-Логвиненко |
| المساهمون: | The article was written within the framework of the state assignment 056-00034-21-00, Статья написана в рамках государственного задания 056-00034-21-00 |
| المصدر: | Meditsinskiy sovet = Medical Council; № 18 (2022); 30-39 ; Медицинский Совет; № 18 (2022); 30-39 ; 2658-5790 ; 2079-701X |
| بيانات النشر: | REMEDIUM GROUP Ltd. |
| سنة النشر: | 2022 |
| المجموعة: | Medical Council (E-Journal) / Медицинский Совет |
| مصطلحات موضوعية: | фиброз, acute exacerbations of chronic obstructive pulmonary disease, respiratory viruses, inflammation, fibrosis, обострение хронической обструктивной болезни легких, респираторные вирусы, воспаление |
| الوصف: | Introduction. Inflammation in viral-induced acute exacerbations of chronic obstructive pulmonary disease (COPD) is not studied enough.The aim was to establish molecular pattern of inflammation in viral-induced acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in comparison with bacterial AECOPD and to reveal associations with AECOPD phenotype and subsequent COPD progression.Materials and methods. Subjects hospitalized with acute exacerbations of COPD (AECOPD) of which 60 were viral, 60 were bacterial and 60 were viral-bacterial were recruited to single center prospective (52 weeks) cohort study. Control group – 30 healthy people. COPD were diagnosed previously during stable phase of the disease according to spirographic criteria. Viral AECOPD were confirmed by detection of RNA of influenza A and B, respiratory syncytial virus, rhinovirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in sputum or bronchoalveolar lavage fluid (BALF) using reverse transcription-polymerase chain reaction (RT-PCR). Bacterial AECOPD were confirmed by sputum/BALF neutrophilia or elevated blood procalcitonin levels or by detecting bacteria by standard culture method. Plasma concentrations of cytokines, fibrotic markers, enzymes were measured by enzyme-linked immunosorbent assay, plasma fibrinogen – by Clauss method. Complex lung function investigation, Dopplerechocardiography, subsequent AECOPD assessment were done. Kruskal-Wallis and chi-square test were used to compare groups, Cox regression and linear regression – to explore relationships.Results. Viral AECOPD were characterized by highest plasma concentrations of Eosinophilic cationic protein (62,3 (52,4; 71,0) ng/ml)), interleukin-5 (IL-5) (11,3 (8,4; 15,9) pg/ml), fibroblast growth factor-2 (FGF-2) (10,4 (6,2; 14,9) pg/ml), transforming growth factor-β1 (TGF-β1) (922,4 (875,7; 953,8) pg/ml), hyaluronic acid (185,4 (172,8; 196,3) ng/ml), amino-terminal propeptide of type III procollagen (PIIINP) (249,2 (225,1; 263,7) ng/ml), matrix ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.21518/2079-701X-2022-16-18-30-39 |
| الإتاحة: | https://doi.org/10.21518/2079-701X-2022-16-18-30-39Test https://doi.org/10.1183/23120541.00198-2021Test https://doi.org/10.1016/j.micpath.2017.10.021Test https://doi.org/10.2147/COPD.S306916Test https://doi.org/10.4046/trd.2021.0080Test https://doi.org/10.3389/fmed.2020.627278Test https://doi.org/10.1159/000520196Test https://doi.org/10.1136/thoraxjnl-2011-201518Test https://doi.org/10.18093/0869-0189-2020-30-1-42-52Test https://doi.org/10.1186/s12874-022-01616-7Test |
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| رقم الانضمام: | edsbas.AAD842C3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.21518/2079-701X-2022-16-18-30-39 |
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