التفاصيل البيبلوغرافية
| العنوان: |
MicroRNA-20a contributes to cisplatin-resistance and migration of OVCAR3 ovarian cancer cell line. |
| المؤلفون: |
YANKUN LIU1, SUGUI HAN2, YUHUI LI3, YAN LIU4, DI ZHANG1, YUFENG LI1 fengfly01@163.com, JINGHUA ZHANG1 jinghuazhang2010@yahoo.com |
| المصدر: |
Oncology Letters. Aug2017, Vol. 14 Issue 2, p1780-1786. 7p. |
| مصطلحات موضوعية: |
*MICRORNA, *CISPLATIN, *OVARIAN cancer treatment, *CANCER cell migration, *DRUG resistance in cancer cells, *CANCER cell proliferation |
| مستخلص: |
MicroRNAs (miRs) have been reported to be associated with the development of numerous types of cancer. However, the function of miRs in human ovarian carcinoma chemoresistance remains largely undefined. In the present study, cell chemotherapy combined with a Cell Counting Kit-8 assay demonstrated that miR-20a performed important roles in ovarian cancer cells chemoresistance. Flow cytometry, cellular proliferation assays and Transwell assays results revealed that the proliferation and migration rates of OVCAR3/DDP cells were increased in comparison with parental cells. Western blot analysis results suggested that epithelial-mesenchymal transition (EMT) activated by miR-20a contributed to OVCAR3/DDP cell migration. The present study highlighted the importance of miR-20a in regulating the chemoresistant properties of OVCAR3 cells and promoting cisplatin-resistant cell migration by activating EMT. The results of present study may therefore provide novel insights into reversing the chemoresistance of ovarian cancer and improving its treatment. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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