المؤلفون: Ianevski, Aleksandr, Yao, Rouan, Simonsen, Ronja M., Myhre, Vegard, Ravlo, Erlend, Kaynova, Gerda D., Zusinaite, Eva, White, Judith M., Polyak, Stephen J., Oksenych, Valentyn, Windisch, Marc P., Pan, Qiuwei, Lastauskiene, Egle, Vitkauskiene, Astra, Matukevicius, Algimantas, Tenson, Tanel, Bjoras, Magnar, Kainov, Denis E.

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki

مصطلحات موضوعية: VIRUS-INFECTION, HEPATITIS-B, IMPDH INHIBITOR, ZIKA VIRUS, MECHANISMS, SALIPHENYLHALAMIDE, REPLICATION, INTERFERONS, OBATOCLAX, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: We thank all the researchers and clinicians developing BSAs and BCCs. This research was funded by the European Regional Development Fund, the Mobilitas Pluss Project grant MOBTT39, National Research Foundation of Korea Grant funded by the Korean government (NRF-2017M3A9G6068246 and 2020R1A2C2009529), and project grant 40275 funded by Norwegian Health Authorities.; Ianevski , A , Yao , R , Simonsen , R M , Myhre , V , Ravlo , E , Kaynova , G D , Zusinaite , E , White , J M , Polyak , S J , Oksenych , V , Windisch , M P , Pan , Q , Lastauskiene , E , Vitkauskiene , A , Matukevicius , A , Tenson , T , Bjoras , M & Kainov , D E 2022 , ' Mono- and combinational drug therapies for global viral pandemic preparedness ' , iScience , vol. 25 , no. 4 , 104112 . https://doi.org/10.1016/j.isci.2022.104112Test; ORCID: /0000-0002-7780-482X/work/113363899; d8a36a94-918d-4e83-be45-56559cc9e067; http://hdl.handle.net/10138/343736Test; 000787786800011

الإتاحة: http://hdl.handle.net/10138/343736Test

المؤلفون: Ko, Meehyun, Chang, So Young, Byun, Soo Young, Ianevski, Aleksandr, Choi, Inhee, d'Orengiani, Anne-Laure Pham Hung d'Alexandry, Ravlo, Erlend, Wang, Wei, Bjoras, Magnar, Kainov, Denis E., Shum, David, Min, Ji-Young, Windisch, Marc P.

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki

مصطلحات موضوعية: Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus disease, clinical isolate, high-content screening, FDA-approved drugs, drug repurposing, drug combinations, lung organoids, COVID-19, pandemic, EAST RESPIRATORY SYNDROME, SYNDROME CORONAVIRUS INFECTION, REPLICATION, PNEUMONIA, 3111 Biomedicine, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: Funding: This research was supported by the National Research Foundation (NRF) of Korea, which is funded by the Ministry of Science and ICT [2016M3A9B6918984, 2017M3A9G6068245, 2017M3A9G6068246], and by the European Regional Development Fund, the Mobilitas Pluss Project MOBTT39 (to D.E.K.).; Ko , M , Chang , S Y , Byun , S Y , Ianevski , A , Choi , I , d'Orengiani , A-L P H DA , Ravlo , E , Wang , W , Bjoras , M , Kainov , D E , Shum , D , Min , J-Y & Windisch , M P 2021 , ' Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19 ' , Viruses (Basel) , vol. 13 , no. 4 , 651 . https://doi.org/10.3390/v13040651Test; ORCID: /0000-0002-7780-482X/work/95929901; bea45d28-ce72-471a-9c31-d0fc919b7ced; http://hdl.handle.net/10138/331747Test; 000643771500001

الإتاحة: http://hdl.handle.net/10138/331747Test

المؤلفون: Bulanova, Daria, Ianevski, Aleksandr, Bugai, Andrii, Akimov, Yevhen, Kuivanen, Suvi, Paavilainen, Henrik, Kakkola, Laura, Nandania, Jatin, Turunen, Laura, Ohman, Tiina, Ala-Hongisto, Hanna, Pesonen, Hanna M., Kuisma, Marika S., Honkimaa, Anni, Walton, Emma L., Oksenych, Valentyn, Lorey, Martina B., Guschin, Dmitry, Shim, Jungmin, Kim, Jinhee, Than, Thoa T., Chang, So Young, Hukkanen, Veijo, Kulesskiy, Evgeny, Marjomaki, Varpu S., Julkunen, Ilkka, Nyman, Tuula A., Matikainen, Sampsa, Saarela, Jani S., Sane, Famara, Hober, Didier, Gabriel, Guelsah, De Brabander, Jef K., Martikainen, Miika, Windisch, Marc P., Min, Ji-Young, Bruzzone, Roberto, Aittokallio, Tero, Vaha-Koskela, Markus, Vapalahti, Olli, Pulk, Arto, Velagapudi, Vidya, Kainov, Denis E.

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Medicum, Department of Biochemistry and Developmental Biology, Department of Virology, Institute of Biotechnology, Clinicum, Reumatologian yksikkö, Department of Medicine, Tero Aittokallio / Principal Investigator, Bioinformatics, Olli Pekka Vapalahti / Principal Investigator, Veterinary Biosciences, Veterinary Microbiology and Epidemiology, Viral Zoonosis Research Unit, HUS Internal Medicine and Rehabilitation, Computational Systems Medicine, Molecular Systems Biology

مصطلحات موضوعية: apoptosis, antiviral agent, innate immunity, host response, CHRONIC LYMPHOCYTIC-LEUKEMIA, ZIKA VIRUS-INFECTION, X-L INHIBITOR, INFLUENZA-A, FAMILY INHIBITORS, CELLS, SALIPHENYLHALAMIDE, POTENT, TRANSCRIPTION, REPLICATION, Plant biology, microbiology, virology, Biomedicine

وصف الملف: application/pdf

العلاقة: We thank Michelle Becker and Dominic Roy at the Ottawa Hospital Research Institute for generating VA7-mCherry virus. We thank Maria Nurmi from the Institute for Molecular Medicine Finland (FIMM) High Throughput Biomedicine unit (HTB) for preparing pre-drugged assay plates and for assistance with the live cell microscopy. We thank Anirban Maitra from Anderson, USA, for the kind gift of pancreatic cancer cells Pa02C. This study was supported by the J&A Erkko foundation (to Denis E. Kainov.), the European Regional Development Fund, the Mobilitas Pluss Project MOBTT39 (to Denis E. Kainov), a University of Helsinki three-year research grant (No. 465/51/2014, to Denis E. Kainov), the Academy of Finland (grant No. SA259725 to Olli Vapalahti), the Sigrid Juselius Foundation (to Olli Vapalahti), the Robert A. Welch Foundation (grant No. I-1422, to Jef K. De Brabander), EA3610 University of Lille 2 and CHRU Lille grants (to Didier Hober), and the Bio&Medical Technology Development Program of the NRF, funded by the Ministry of Science, ICT and Future Planning, Republic of Korea (grant No. 1601-0302, to Ji-Young Min).; Bulanova , D , Ianevski , A , Bugai , A , Akimov , Y , Kuivanen , S , Paavilainen , H , Kakkola , L , Nandania , J , Turunen , L , Ohman , T , Ala-Hongisto , H , Pesonen , H M , Kuisma , M S , Honkimaa , A , Walton , E L , Oksenych , V , Lorey , M B , Guschin , D , Shim , J , Kim , J , Than , T T , Chang , S Y , Hukkanen , V , Kulesskiy , E , Marjomaki , V S , Julkunen , I , Nyman , T A , Matikainen , S , Saarela , J S , Sane , F , Hober , D , Gabriel , G , De Brabander , J K , Martikainen , M , Windisch , M P , Min , J-Y , Bruzzone , R , Aittokallio , T , Vaha-Koskela , M , Vapalahti , O , Pulk , A , Velagapudi , V & Kainov , D E 2017 , ' Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins ' , Viruses (Basel) , vol. 9 , no. 10 , 271 . https://doi.org/10.3390/v9100271Test; ORCID: /0000-0001-6647-8873/work/45026374; ORCID: /0000-0003-2270-6824/work/39203955; ORCID: /0000-0001-7306-7175/work/39204449; ORCID: /0000-0002-0886-9769/work/41148342; ORCID: /0000-0003-1920-6044/work/39205482; ORCID: /0000-0001-5605-6714/work/39204246; ORCID: /0000-0002-7780-482X/work/68617255; ORCID: /0000-0003-0274-4794/work/155648892; http://hdl.handle.net/10138/228889Test; 975f3a2c-436c-4e66-a79c-c7b9743a5f75; 85030546123; 000414617500008

الإتاحة: http://hdl.handle.net/10138/228889Test

المؤلفون: Andersen, Petter I., Ianevski, Aleksandr, Lysvand, Hilde, Oksenych, Valentyn, Bjørås, Magnar, Telling, Kaidi, Lutsar, Irja, Dampis, Uga, Irie, Yasuhiko, Tenson, Tanel, Kantele, Anu, Kainov, Denis

المساهمون: Department of Medicine, HUS Inflammation Center, Institute for Molecular Medicine Finland

مصطلحات موضوعية: ZIKA VIRUS-INFECTION, Antiviral drug, 195 COUNTRIES, INHIBITION, GLOBAL BURDEN, Virus, BSAAs, ANIMAL-MODELS, 317 Pharmacy, Broad-spectrum antiviral agents, DISEASES, 3121 General medicine, internal medicine and other clinical medicine, REPLICATION, SYSTEMATIC ANALYSIS, DRUGS, Drug discovery and development, ROTAVIRUS INFECTION

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1593::4c7d3b2b3863a4d6bc47e2f7dd067ab4Test
http://hdl.handle.net/10138/316038Test