المؤلفون: Piani F., Reinicke T., Lytvyn Y., Melena I., Lovblom L. E., Lai V., Tse J., Cham L., Orszag A., Perkins B. A., Cherney D. Z. I., Bjornstad P.

المساهمون: Piani F., Reinicke T., Lytvyn Y., Melena I., Lovblom L.E., Lai V., Tse J., Cham L., Orszag A., Perkins B.A., Cherney D.Z.I., Bjornstad P.

مصطلحات موضوعية: Copeptin, Intraglomerular hemodynamic function, RAAS, Type 1 diabete, Adult, Angiotensin II, Glycopeptide, Hemodynamic, Human, Renin, Vascular Resistance, Diabetes Mellitus, Type 1, Diabetic Nephropathie, Renin-Angiotensin System, Vasopressins

الوصف: Objective: Arginine vasopressin (AVP) and its surrogate, copeptin, have been implicated in diabetic kidney disease (DKD) pathogenesis, which develops in a subset of people with longstanding type 1 diabetes, but not in others (DKD Resistors). We hypothesized that patients with DKD would exhibit higher copeptin concentrations vs. DKD Resistors. Methods: Participants with type 1 diabetes (n = 62, duration ≥50 years) were stratified into 42 DKD Resistors and 20 with DKD (eGFR ≤60 mL/min/1.73m2 or ≥30 mg/day urine albumin), and age/sex-matched controls (HC, n = 74) were included. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were calculated by inulin and p-aminohippurate clearance before and after angiotensin II (ang II) infusion. Renal vascular resistance (RVR) was calculated as mean arterial pressure/renal blood flow. Plasma copeptin, renin, aldosterone, neutrophil gelatinase-associated lipocalin (NGAL), and urea concentrations were measured, along with 24-h urine volume. Results: DKD resistors had lower copeptin (95% CI: 4.0 [3.4–4.8] pmol/l) compared to DKD (5.8 [4.5–7.6] pmol/l, p = 0.02) and HC (4.8 [4.1–5.5] pmol/l, p = 0.01) adjusting for age, sex and HbA1c. In type 1 diabetes, higher copeptin correlated with lower GFR (r: −0.32, p = 0.01) and higher renin concentration (r: 0.40, p = 0.002) after multivariable adjustments. These relationships were not evident in HC. Copeptin inversely associated with RVR change following exogenous ang II only in participants with type 1 diabetes (β ± SE: −6.9 ± 3.4, p = 0.04). Conclusions: In longstanding type 1 diabetes, copeptin was associated with intrarenal renin–angiotensin–aldosterone system (RAAS) activation and renal hemodynamic function, suggesting interplay between AVP and RAAS in DKD pathogenesis.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33288413; info:eu-repo/semantics/altIdentifier/wos/WOS:000618629400020; volume:35; issue:3; firstpage:1; lastpage:6; numberofpages:6; journal:JOURNAL OF DIABETES AND ITS COMPLICATIONS; http://hdl.handle.net/11585/855572Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85097235169

الإتاحة: https://doi.org/10.1016/j.jdiacomp.2020.107807Test
http://hdl.handle.net/11585/855572Test

المؤلفون: Federica Piani, Trenton Reinicke, Leif E. Lovblom, Josephine Tse, Vesta Lai, Isabella Melena, Bruce A. Perkins, Yuliya Lytvyn, David Z.I. Cherney, Andrej Orszag, Petter Bjornstad, Leslie Cham

المساهمون: Piani F., Reinicke T., Lytvyn Y., Melena I., Lovblom L.E., Lai V., Tse J., Cham L., Orszag A., Perkins B.A., Cherney D.Z.I., Bjornstad P.

المصدر: J Diabetes Complications

مصطلحات موضوعية: Adult, medicine.medical_specialty, Type 1 diabete, Vasopressins, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Glycopeptide, Article, Renin-Angiotensin System, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Copeptin, RAAS, Internal medicine, Diabetes mellitus, Renin, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Hemodynamic, Type 1 diabetes, Aldosterone, business.industry, Angiotensin II, Glycopeptides, Hemodynamics, Effective renal plasma flow, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Intraglomerular hemodynamic function, Renal blood flow, Diabetic Nephropathie, Vascular Resistance, business, Human

الوصف: Objective Arginine vasopressin (AVP) and its surrogate, copeptin, have been implicated in diabetic kidney disease (DKD) pathogenesis, which develops in a subset of people with longstanding type 1 diabetes, but not in others (DKD Resistors). We hypothesized that patients with DKD would exhibit higher copeptin concentrations vs. DKD Resistors. Methods Participants with type 1 diabetes (n = 62, duration ≥50 years) were stratified into 42 DKD Resistors and 20 with DKD (eGFR ≤60 mL/min/1.73m2 or ≥30 mg/day urine albumin), and age/sex-matched controls (HC, n = 74) were included. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were calculated by inulin and p-aminohippurate clearance before and after angiotensin II (ang II) infusion. Renal vascular resistance (RVR) was calculated as mean arterial pressure/renal blood flow. Plasma copeptin, renin, aldosterone, neutrophil gelatinase-associated lipocalin (NGAL), and urea concentrations were measured, along with 24-h urine volume. Results DKD resistors had lower copeptin (95% CI: 4.0 [3.4–4.8] pmol/l) compared to DKD (5.8 [4.5–7.6] pmol/l, p = 0.02) and HC (4.8 [4.1–5.5] pmol/l, p = 0.01) adjusting for age, sex and HbA1c. In type 1 diabetes, higher copeptin correlated with lower GFR (r: −0.32, p = 0.01) and higher renin concentration (r: 0.40, p = 0.002) after multivariable adjustments. These relationships were not evident in HC. Copeptin inversely associated with RVR change following exogenous ang II only in participants with type 1 diabetes (β ± SE: −6.9 ± 3.4, p = 0.04). Conclusions In longstanding type 1 diabetes, copeptin was associated with intrarenal renin–angiotensin–aldosterone system (RAAS) activation and renal hemodynamic function, suggesting interplay between AVP and RAAS in DKD pathogenesis.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc299dccd224b7248c6cb37ed3223499Test
http://hdl.handle.net/11585/855572Test