التفاصيل البيبلوغرافية
| العنوان: |
盐酸小檗碱缓释片的研制. (Chinese) |
| العنوان البديل: |
Study on Preparation of Berberine Hydrochloride Sustained-release Tablets. (English) |
| المؤلفون: |
初明, 刘彦辰, 张明波, 初正云, 徐兰, 周鹏, 杨柯, 马小龙, 陈晓芹, 梁秀军, 王月丹 |
| المصدر: |
Progress in Modern Biomedicine; Aug2016, Vol. 16 Issue 23, p4415-4418, 4p |
| الملخص (بالإنجليزية): |
Objective: Study the formulation and preparation methods of Berberine hydrochloride sustained-release tablets, and investigate its release rate. Methods: With the release rate of Berberine hydrochloride as investigation index, using single factor test method, studied the impact of the amount of hydroxypropyl methyl cellulose (HPMC,) and lactose on release behavior in vitro drug, and determined the best prescription by orthogonal design to the optimize prescription. Results: Best formula is: HPMC-K4Min an amount of 10 %, the amount of lactose 20 %, PVP in an amount of 3 %, microcrystalline cellulose in an amount of 20 %. 2 h accumulated release amount is 30 %, 6 h cumulative release amount of 60 %, and 12 h accumulated release amount is 90 %. Conclusion: Berberine hydrochloride sustained-release tablets prepared according to the best recipes have better release behavior, can basically meet the requirements of sustained-release tablets. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的:研究盐酸小檗碱缓释片的配方与制备方法，考察其释放度。方法:以盐酸小檗碱释放度为考察指标，采用单因素试验 法，考察了羟丙基甲基纤维素(HPMC)和乳糖的用量对药物体外释放行为的影响，并采用正交设计实验对处方进行优化，确定最 佳处方。结果:最佳配方为HPMC-K4M的用量为10 %，乳糖用量为20 %，PVP 的用量为3 %，微晶纤维素的用量为20 %。2 h累 积释药量为30 %，6 h累积释药量为60 %，12 h 累积释药量为90 %。结论:按最佳配方制备的盐酸小檗碱缓释片有较好的缓释行 为，基本上能满足缓释片的释放要求。 [ABSTRACT FROM AUTHOR] |
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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
