التفاصيل البيبلوغرافية
| العنوان: |
Alloimmunization In Patients And Donors Visiting Blood Bank of A Tertiary Care Hospital In North India. |
| المؤلفون: |
Gupta, Nidhi1, Mehdi, Syed Riaz2, Zaidi, Noorin3 noorinzaidi123@gmail.com, Ahmad, Sharique3 |
| المصدر: |
National Journal of Integrated Research in Medicine. Jul/Aug2018, Vol. 9 Issue 4, p49-54. 6p. |
| مصطلحات موضوعية: |
*IMMUNIZATION, *BLOOD banks, *ERYTHROCYTES |
| مستخلص: |
Objective: Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients and is an immune response against foreign RBC antigens; this generally occurs after sensitization due to blood transfusions and pregnancies. We undertook this study to determine prevalence and specificity of RBC alloantibodies in patients and donor attending blood bank of a tertiary care hospital in North India. Method: This was a prospective observational study carried out at Department of Pathology and Blood Bank of Eras Lucknow Medical College and Hospital, Lucknow. Study was carried out for a duration of six months, from July 2016 to December 2016. Proper approval was taken from the institution Ethics Committee. Antibody screening and indentification was carried out in Total 700 cases including 350 Patients and 350 Donors using the ID SYSTEM (ID - Centrifuge, 37° C Dry Incubator) ID-Dia Cell I-II-III and ID-Dia Panel reagents (Diamed- Biorad, India, Private Limited). ABO and Rh blood groups were done using ID DiaClon ABO/D Grouping cards, containing monoclonal anti-A, anti-B & anti-D suspended in the gel. Results: The incidence of alloimmunization was 0.9% among patients and 0.29% among donors. Among 3 patients detected positive for red cell alloantibody, 2 cases were positive for Anti-D and one was positive for Anti-K alloantibody. The single red cell alloantibody positive donor was positive for Anti-M antibody. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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