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المؤلفون: Tatjana Weidner, Jessica Hartmann, Annika M. Frank, Christian J. Buchholz, Julia Brynza, Wolfgang Uckert
المصدر: Human Gene Therapy. 31:679-691
مصطلحات موضوعية: Recombinant Fusion Proteins, Genetic enhancement, Genetic Vectors, Receptors, Antigen, T-Cell, CD8-Positive T-Lymphocytes, Gene delivery, Biology, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Transduction, Genetic, In vivo, Neoplasms, Genetics, Animals, Humans, Cytotoxic T cell, Molecular Biology, 030304 developmental biology, 0303 health sciences, Lentivirus, Gene Transfer Techniques, Genetic Therapy, Macaca mulatta, Ankyrin Repeat, Cell biology, HEK293 Cells, DARPin, 030220 oncology & carcinogenesis, Chronic Disease, Ribosome display, Leukocytes, Mononuclear, Molecular Medicine, Ankyrin repeat, Macaca nemestrina, CD8, Single-Chain Antibodies, T-Lymphocytes, Cytotoxic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd89e510e4fb194b27cf13b3f13b8e5aTest
https://doi.org/10.1089/hum.2019.248Test -
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المؤلفون: Uwe Zangemeister-Wittke, Fabian Brandl, Andreas Plückthun, Martina Zimmermann, Martin Béhé, Hannes Merten
المصدر: Journal of Controlled Release. 307:379-392
مصطلحات موضوعية: Biodistribution, Recombinant Fusion Proteins, Pharmaceutical Science, 02 engineering and technology, DNA-binding protein, Mice, 03 medical and health sciences, chemistry.chemical_compound, Neoplasms, Animals, Distribution (pharmacology), Tissue Distribution, 030304 developmental biology, Tumor marker, 0303 health sciences, Chemistry, Epithelial cell adhesion molecule, Epithelial Cell Adhesion Molecule, 021001 nanoscience & nanotechnology, Fusion protein, Extravasation, Ankyrin Repeat, Cell biology, DARPin, Female, Peptides, 0210 nano-technology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2118c77f5bc0663751dc5d252d686eaTest
https://doi.org/10.1016/j.jconrel.2019.06.030Test -
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المساهمون: University of Zurich, Sedlák, Erik
مصطلحات موضوعية: 1303 Biochemistry, 2100 General Energy, Flavodoxin, Recombinant Fusion Proteins, 610 Medicine & health, 2002 Economics and Econometrics, Protein Engineering, Affinity chromatography, Biochemistry, Chromatography, Affinity, Maltose-Binding Proteins, Green fluorescent protein, protein-protein interaction, chemistry.chemical_compound, Maltose-binding protein, 1315 Structural Biology, Structural Biology, Protein purification, 10019 Department of Biochemistry, 1312 Molecular Biology, Escherichia coli, Designed Ankyrin Repeat Proteins, Molecular Biology, biology, General Medicine, Maltose, Fusion protein, DARPin, chemistry, biology.protein, 570 Life sciences
وصف الملف: Nemergut_et_al_2021.pdf - application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6a2228a9d2463322129cde2930c8fcTest
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المؤلفون: Daniel Brigger, Pascal Guntern, Theodore S. Jardetzky, Pascal Gasser, Alexander Eggel, Luke F. Pennington
المصدر: J Allergy Clin Immunol
مصطلحات موضوعية: 0301 basic medicine, Allergy, Ovalbumin, Recombinant Fusion Proteins, Immunology, Mice, Transgenic, Yeast display, Immunoglobulin E, Article, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Immunology and Allergy, Medicine, Animals, Humans, 610 Medicine & health, Receptor, Anaphylaxis, biology, Molecular Structure, business.industry, Receptors, IgE, Allergens, medicine.disease, Basophils, 030104 developmental biology, 030228 respiratory system, DARPin, Drug Design, biology.protein, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d4146795d788ed6fb76b6035e78caaTest
https://europepmc.org/articles/PMC8502201Test/ -
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المؤلفون: Erin A. Stephens, Lutz Kummer, Andreas Plückthun, Fabian Brandl, Dujduan Waraho-Zhmayev, Matthew P. DeLisa, Allen Jiang, Morgan B. Ludwicki, Bunyarit Meksiriporn, Hyeon-Cheol Lee
المساهمون: University of Zurich, DeLisa, Matthew P
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, High-throughput screening, Recombinant Fusion Proteins, Science, Protein design, General Physics and Astronomy, 610 Medicine & health, 1600 General Chemistry, 02 engineering and technology, Computational biology, Protein Engineering, DNA-binding protein, General Biochemistry, Genetics and Molecular Biology, Article, beta-Lactamases, Substrate Specificity, Applied microbiology, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, 10019 Department of Biochemistry, Protein phosphorylation, Phosphorylation, lcsh:Science, Mitogen-Activated Protein Kinase 1, Multidisciplinary, Chemistry, Escherichia coli Proteins, General Chemistry, Protein engineering, 021001 nanoscience & nanotechnology, 3100 General Physics and Astronomy, Ankyrin Repeat, 030104 developmental biology, DARPin, 570 Life sciences, biology, Ankyrin repeat, lcsh:Q, Target protein, 0210 nano-technology, Carrier Proteins, Protein Processing, Post-Translational
وصف الملف: Meksiriporn_et_al._2019.pdf - application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d302b192cdf01bc46106cd7c539ecc11Test
https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0bTest -
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المؤلفون: Giovanni Staurenghi, Francisco J. López, Kimmie Kim, Hohman Thomas C, Derek Y Kunimoto, David Callanan, Susan Schneider, Janet K. Cheetham, Sunil S. Patel, Sebastian Wolf, Raj K Maturi
المصدر: Journal of Ocular Pharmacology and Therapeutics
Callanan, David; Kunimoto, Derek; Maturi, Raj K; Patel, Sunil S; Staurenghi, Giovanni; Wolf, Sebastian; Cheetham, Janet K; Hohman, Thomas C; Kim, Kimmie; López, Francisco J; Schneider, Susan (2018). Double-Masked, Randomized, Phase 2 Evaluation of Abicipar Pegol (an Anti-VEGF DARPin Therapeutic) in Neovascular Age-Related Macular Degeneration. Journal of ocular pharmacology and therapeutics, 34(10), pp. 700-709. Mary Ann Liebert 10.1089/jop.2018.0062 <http://dx.doi.org/10.1089/jop.2018.0062Test>مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, 0301 basic medicine, genetic structures, abicipar pegol, Visual Acuity, Angiogenesis Inhibitors, Macular Degeneration, chemistry.chemical_compound, 0302 clinical medicine, Pharmacology (medical), 610 Medicine & health, Anti vegf, vascular endothelial growth factor, humanities, Vascular endothelial growth factor, Treatment Outcome, Choroidal neovascularization, DARPin, anti-VEGF, Intravitreal Injections, Female, medicine.symptom, Tomography, Optical Coherence, medicine.drug, medicine.medical_specialty, Recombinant Fusion Proteins, Abicipar Pegol, choroidal neovascularization, Retina, 03 medical and health sciences, Double-Blind Method, Ranibizumab, Ophthalmology, medicine, Humans, age-related macular degeneration, Aged, Pharmacology, optical coherence tomography, business.industry, Original Articles, Macular degeneration, medicine.disease, eye diseases, 030104 developmental biology, chemistry, 030221 ophthalmology & optometry, sense organs, business, Vascular endothelial growth factor binding
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316feb66c16cd86ddf896bd0bb94c63cTest
https://doi.org/10.1089/jop.2018.0062Test -
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المؤلفون: O N Shilova, Sergey M. Deyev, R. V. Petrov, E O Kuzichkina
المصدر: Doklady Biochemistry and Biophysics. 482:245-248
مصطلحات موضوعية: 0301 basic medicine, Receptor, ErbB-2, Recombinant Fusion Proteins, media_common.quotation_subject, education, Biophysics, Biochemistry, Fluorescence, law.invention, 03 medical and health sciences, law, Cell Line, Tumor, Humans, Her2 receptor, Receptor, Internalization, media_common, Flavoproteins, Chemistry, General Chemistry, General Medicine, Recombinant Proteins, Fluorescence intensity, 030104 developmental biology, DARPin, Cell culture, Recombinant DNA, Female, Single-Chain Antibodies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cde34da2656d5a82f347c0185bdb698Test
https://doi.org/10.1134/s1607672918050046Test -
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المؤلفون: Analia Azaro, Jordi Rodon, Constanza Linossi, Richard D. Baird, Ulrike Fiedler, Simon Lord, Keith M. Dawson, Aurelius Omlin, Nicolas Leupin, Andreas Harstrick, Stefanie Fischer, Michael T. Stumpp, Christof Zitt, Mark R. Middleton, Adrian L. Harris
المصدر: Journal of Clinical Oncology
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Vascular Endothelial Growth Factor A, Cancer Research, VEGF receptors, Recombinant Fusion Proteins, Antineoplastic Agents, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Neoplasms, Tumor Microenvironment, Medicine, Humans, In patient, Clinical Trials, Molecular Targeted Therapy, Infusions, Intravenous, Aged, biology, Dose-Response Relationship, Drug, business.industry, Drug candidate, Hepatocyte Growth Factor, First in human, ORIGINAL REPORTS, Middle Aged, Phase i study, Vascular endothelial growth factor, 030104 developmental biology, Oncology, DARPin, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Hepatocyte growth factor, Female, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16b0da7e7ca61c956dcd61166c92f95Test
https://pubmed.ncbi.nlm.nih.gov/33301375Test -
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المؤلفون: Charles C. Wykoff, Christina Y. Weng, Seenu M. Hariprasad, Rehan M. Hussain, Raya A. Gandhi
المصدر: Expert opinion on biological therapy. 20(9)
مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, medicine.medical_specialty, genetic structures, VEGF receptors, medicine.medical_treatment, Recombinant Fusion Proteins, Clinical Biochemistry, Abicipar Pegol, Angiogenesis Inhibitors, 03 medical and health sciences, chemistry.chemical_compound, Macular Degeneration, 0302 clinical medicine, Ophthalmology, Age related, Drug Discovery, Choroidal neovascular membrane, medicine, Humans, Pharmacology, Inflammation, Clinical Trials as Topic, biology, business.industry, Growth factor, Macular degeneration, medicine.disease, eye diseases, Vascular endothelial growth factor, 030104 developmental biology, Treatment Outcome, chemistry, DARPin, 030220 oncology & carcinogenesis, biology.protein, sense organs, business, Half-Life, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afc5aba83a743ff1b2d99f32be29a9bTest
https://pubmed.ncbi.nlm.nih.gov/32552072Test -
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المؤلفون: Pierluigi Navarra, Achille P. Caputi
المصدر: Current opinion in pharmacology. 51
مصطلحات موضوعية: 0301 basic medicine, Ankyrins, Biomedical Research, Settore BIO/14 - FARMACOLOGIA, Recombinant Fusion Proteins, Pharmacology, Antibodies, Monoclonal, Humanized, 030226 pharmacology & pharmacy, Epitope, 03 medical and health sciences, 0302 clinical medicine, Basic research, Drug Discovery, medicine, Drug approval, Ankyrin, Animals, Humans, Drug Approval, chemistry.chemical_classification, Clinical Trials as Topic, biology, 030104 developmental biology, N/A, DARPin, chemistry, biology.protein, Ankyrin repeat, Ranibizumab, Antibody, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd090b82c2b2246193dd5c71bd9d5f0cTest
https://pubmed.ncbi.nlm.nih.gov/32674998Test
