التفاصيل البيبلوغرافية
| العنوان: |
Animal models of COPD: What do they tell us? |
| المؤلفون: |
Jones, B, Donovan, C, Liu, G, Gomez, HM, Chimankar, V, Harrison, CL, Wiegman, CH, Adcock, IM, Knight, DA, Hirota, JA, Hansbro, PM |
| المساهمون: |
Commission of the European Communities, UCB Celltech Ltd |
| بيانات النشر: |
Wiley, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
NUCLEOTIDE-BINDING DOMAIN, AIRWAY INFLAMMATION, RECEPTOR-ALPHA, Respiratory System, therapies, therapeutic targets, OBSTRUCTIVE PULMONARY-DISEASE, chronic obstructive pulmonary disease, Pulmonary Disease, Chronic Obstructive, disease mechanisms, SMOKE-INDUCED EMPHYSEMA, Animals, Humans, OXIDATIVE STRESS, INDUCED LUNG INFLAMMATION, Science & Technology, GUINEA-PIGS, MOUSE MODEL, 11 Medical And Health Sciences, animal models, respiratory tract diseases, Disease Models, Animal, Disease Progression, Airway Remodeling, MAINSTREAM CIGARETTE-SMOKE, Life Sciences & Biomedicine |
| الوصف: |
© 2016 Asian Pacific Society of Respirology COPD is a major cause of global mortality and morbidity but current treatments are poorly effective. This is because the underlying mechanisms that drive the development and progression of COPD are incompletely understood. Animal models of disease provide a valuable, ethically and economically viable experimental platform to examine these mechanisms and identify biomarkers that may be therapeutic targets that would facilitate the development of improved standard of care. Here, we review the different established animal models of COPD and the various aspects of disease pathophysiology that have been successfully recapitulated in these models including chronic lung inflammation, airway remodelling, emphysema and impaired lung function. Furthermore, some of the mechanistic features, and thus biomarkers and therapeutic targets of COPD identified in animal models are outlined. Some of the existing therapies that suppress some disease symptoms that were identified in animal models and are progressing towards therapeutic development have been outlined. Further studies of representative animal models of human COPD have the strong potential to identify new and effective therapeutic approaches for COPD. |
| وصف الملف: |
application/pdf |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c01f0701d91732f12c316399134abeaTest
http://hdl.handle.net/10044/1/41697Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.dedup.wf.001..2c01f0701d91732f12c316399134abea |
| قاعدة البيانات: |
OpenAIRE |
