المؤلفون: Susanna Wiegand, Barbara Wolters, Lex H.T. Van der Ploeg, Fred T. Fiedorek, K Mai, Katja Weiß, Heike Biebermann, Patrick Scheerer, Anne Müller, Peter Kühnen, Nicolas A. Heyder, Joachim Spranger, Gunnar Kleinau, Shubh D. Sharma, Oliver Blankenstein, Ulrike Blume-Peytavi, I. Sadaf Farooqi, Annette Grüters, Irina Jahnke, Heiko Krude, Jacek Mokrosinski, Keith Gottesdiener, Karine Clément, Lia Puder, Christine Poitou

المصدر: Nature Medicine. 24:551-555

مصطلحات موضوعية: 0301 basic medicine, Agonist, Setmelanotide, medicine.medical_specialty, Leptin Deficiency, medicine.drug_class, business.industry, Leptin, 030209 endocrinology & metabolism, NFAT, General Medicine, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Weight loss, Internal medicine, medicine, Signal transduction, medicine.symptom, Receptor, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::006ce506a03e3c1266b9811152cde775Test
https://doi.org/10.1038/s41591-018-0015-9Test

المؤلفون: Gunnar Kleinau, Harald Jüppner, Sarah Paisdzior, Heiko Krude, John Gregory, Dirk Schnabel, Mehul T. Dattani, Thomas J. Gardella, Louise C. Wilson, Michael Mannstadt, Detlef Bockenhauer, Ian Tully, Jeremy Allgrove, Sarah Kiff, Heike Biebermann, Patrick Scheerer, Monica Reyes, Annette Grüters

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Heterozygote, Gs alpha subunit, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, DNA Mutational Analysis, Puberty, Precocious, 030209 endocrinology & metabolism, Context (language use), Biology, medicine.disease_cause, Biochemistry, Bone and Bones, Adenylyl cyclase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Loss of Function Mutation, Internal medicine, medicine, GNAS complex locus, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Humans, Receptor, Pseudohypoparathyroidism, Clinical Research Articles, Alleles, G protein-coupled receptor, Mutation, Biochemistry (medical), medicine.disease, 030104 developmental biology, Phenotype, chemistry, Amino Acid Substitution, Gain of Function Mutation, biology.protein, Female, Maternal Inheritance, Hyponatremia

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6549249d249e21c347aa4043aa794a5dTest
https://europepmc.org/articles/PMC6380466Test/

المؤلفون: Lutz Schomburg, Josef Köhrle, Laura Kalveram, Annette Grüters-Kieslich, Heike Biebermann, Mariusz W. Szkudlinski, Gunnar Kleinau

المصدر: Molecular Endocrinology. 30:954-964

مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, medicine.drug_class, Mutant, Thyrotropin, 030209 endocrinology & metabolism, Biology, medicine.disease_cause, Chorionic Gonadotropin, Thyrotropin receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine, Humans, Receptor, Molecular Biology, Glycoproteins, Genetics, Mutation, Minireviews, General Medicine, Luteinizing Hormone, medicine.disease, Congenital hypothyroidism, 030104 developmental biology, Follicle Stimulating Hormone, Signal transduction, hormones, hormone substitutes, and hormone antagonists, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0415d665f63a2a387870eb723a370cTest
https://doi.org/10.1210/me.2016-1065Test

المؤلفون: Anne Rediger, Carolin L. Piechowski, Anne Müller, Gunnar Kleinau, Juliane Pratzka, Jessica Mühlhaus, Heike Biebermann, Christina Lagemann, Patrick Tarnow, Heiko Krude, Annette Grüters

المصدر: Journal of Molecular Endocrinology. 51:109-118

مصطلحات موضوعية: Models, Molecular, Dimer, Receptor expression, Cell Membrane, Protein Structure, Secondary, Energy homeostasis, Melanocortin 4 receptor, chemistry.chemical_compound, Transmembrane domain, Endocrinology, Amino Acid Substitution, chemistry, Mutation, Biophysics, Animals, Receptor, Melanocortin, Type 4, Protein Multimerization, Receptor, Molecular Biology, Intracellular, Protein Binding, Signal Transduction, G protein-coupled receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fc1363e9ef57476a967ecd5ec30bcfTest
https://doi.org/10.1530/jme-13-0061Test

المؤلفون: Anne Müller, Lars Niederstadt, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann

المساهمون: AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology

المصدر: Frontiers in endocrinology, 7:109
Front. Endocrin. 7:109 (2016)
Frontiers in Endocrinology, Vol 7 (2016)
Frontiers in endocrinology, 7. Frontiers Media S.A.
Frontiers in Endocrinology

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Receptor expression, Inflammation, G protein coupled receptor, Biology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Internal medicine, medicine, Receptor, Original Research, G protein-coupled receptor, protein network, lcsh:RC648-665, Melanocortin 3 receptor, Melanocortin 4 receptor, 030104 developmental biology, weight regulation, inflammation, G Protein Coupled Receptor, Protein Complementation Assay, Protein Network, Weight Regulation, Tumor necrosis factor alpha, medicine.symptom, Melanocortin, protein complementation assay, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2047967e5c6904a2dd0c25d8a198bfbeTest
https://doi.org/10.17169/refubium-25040Test

المؤلفون: Jessica Mühlhaus, Martin Klingenspor, Harald Brumm, S. Scherag, Johannes Hebebrand, Heike Biebermann, Anke Hinney, Susanna Wiegand, Florian Bolze, Heiko Krude, Annette Grüters

المصدر: Obesity. 20:1074-1081

مصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, Nonsense mutation, Mutant, Medizin, Medicine (miscellaneous), Biology, Endocrinology, Humans, Obesity, Receptor, Gene, Genetics, Oxadiazoles, Nutrition and Dietetics, Wild type, Stop codon, Cell biology, Melanocortin 4 receptor, Aminoglycosides, Blood-Brain Barrier, Codon, Nonsense, Codon, Terminator, Receptor, Melanocortin, Type 4, Female, Signal transduction, Energy Metabolism, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7816d403e052f25779dfc52229e0869Test
https://doi.org/10.1038/oby.2011.202Test

المؤلفون: Heike Biebermann, Daniela Handke, Heiko Krude, Peter Kühnen, Annette Grüters, Burkhard Wiesner, Gunnar Kleinau, Franziska Winkler, Jenny Eichhorst, Fergus J. Cameron, Burkhard Gerling, Anke Teichmann

المصدر: The Journal of Clinical Endocrinology & Metabolism. 97:E228-E232

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Amino Acid Motifs, Clinical Biochemistry, Biology, Transfection, Biochemistry, Protein Structure, Secondary, Receptors, G-Protein-Coupled, Substrate Specificity, Thyrotropin receptor, Endocrinology, Catalytic Domain, Internal medicine, Helix (Snails), Chlorocebus aethiops, medicine, Animals, Humans, Child, Receptor, Conserved Sequence, G protein-coupled receptor, Genetics, Biochemistry (medical), Infant, Newborn, Receptors, Thyrotropin, Transmembrane domain, HEK293 Cells, Structural Homology, Protein, COS Cells, Mutation, Motif (music), Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca878b66eaaf946d0d01a888dadc5d2Test
https://doi.org/10.1210/jc.2011-2106Test

المؤلفون: Annette Grüters, Heike Biebermann, Carolin L. Piechowski, Heiko Krude, Kirk M. Habegger, Matthias H. Tschöp, Anne Rediger, Gunnar Kleinau

المصدر: Neuroendocrinology. 95:277-288

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Growth hormone secretagogue receptor, Biology, Models, Biological, Cellular and Molecular Neuroscience, Endocrinology, Arcuate nucleus, Internal medicine, medicine, Animals, Humans, Receptors, Ghrelin, Receptor, G protein-coupled receptor, Appetite Regulation, Endocrine and Autonomic Systems, Body Weight, Arcuate Nucleus of Hypothalamus, Melanocortin 3 receptor, Melanocortin 4 receptor, Hypothalamus, Receptor, Melanocortin, Type 4, Protein Multimerization, Melanocortin, hormones, hormone substitutes, and hormone antagonists, Paraventricular Hypothalamic Nucleus, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a7736f337464add9a82eab6f6a8f03Test
https://doi.org/10.1159/000334903Test

المؤلفون: Eva Rettenbacher, Kurt Widhalm, Johannes Hebebrand, Heike Biebermann, Anke Hinney, Harald Brumm, Patrick Tarnow, Petra Ambrugger, Michael Schaefer, Annette Grüters, Anne Rediger, Gerd Krause, Gunnar Kleinau

المصدر: Obesity Facts. 1:155-162

مصطلحات موضوعية: Adult, Male, Models, Molecular, Heterozygote, Health (social science), Adolescent, Mutant, Transfection, Physiology (medical), Chlorocebus aethiops, Animals, Humans, Medicine, Obesity, Receptor, Genes, Dominant, COS cells, business.industry, Wild type, Hydrogen Bonding, Heterozygote advantage, Middle Aged, Cell biology, Transmembrane domain, Child, Preschool, COS Cells, Mutation, Mutation (genetic algorithm), Receptor, Melanocortin, Type 4, Original Article, Female, Signal transduction, business, Dimerization, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54e6a42c15827f45fdbf7c2bbab6c74Test
https://doi.org/10.1159/000138251Test

المؤلفون: Anne Müller, Carolin S. Hoefig, Maxi Cöster, Carolin Leonie Wienchol, Heiko Krude, Jens Mittag, Jessica Mühlhaus, Annette Grüters, Torsten Schöneberg, Heike Biebermann, Jaroslawna Meister, Juliane Dinter, Josef Köhrle, Gunnar Kleinau, Simon Friedrich Jacobi

المصدر: Journal of molecular endocrinology. 54(3)

مصطلحات موضوعية: MAPK/ERK pathway, Male, Mice, 129 Strain, Adrenergic receptor, Drug Evaluation, Preclinical, Gene Expression, GTP-Binding Protein alpha Subunits, Gi-Go, Receptors, G-Protein-Coupled, 3-Iodothyronamine, chemistry.chemical_compound, Islets of Langerhans, Norepinephrine, Endocrinology, Receptors, Adrenergic, alpha-2, TAAR1, Adrenergic alpha-2 Receptor Agonists, Thyronines, Glucose homeostasis, Animals, Humans, Receptor, Molecular Biology, G protein-coupled receptor, Chemistry, Cell biology, Mice, Inbred C57BL, Glucose, HEK293 Cells, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa88e1dab741a73ddd0ec8e5dea8c33aTest
https://pubmed.ncbi.nlm.nih.gov/25878061Test