دورية أكاديمية
Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm
| العنوان: | Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm |
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| المؤلفون: | Jake Goldstein, Robert S Dieter MD RVT ALM, Vinod Bansal MD, Keaton Wieschhaus, Robert S Dieter, Emily Bontekoe, Debra Hoppensteadt PhD, Jawed Fareed PhD |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study profiled biomarkers and laboratory parameters of endothelium dysfunction in patients with ESRD, categorized by additional AFIB and PAD conditions. Methods Citrated blood samples were collected from 95 patients with ESRD. Biomarker levels were measured from plasma samples using sandwich ELISAs, including tissue plasminogen activator (tPA), D-dimer, and nitrotyrosine. Lab parameters, including BUN, calcium, creatinine, parathyroid hormone, phosphate, alkaline phosphatase, ferritin, transferrin, and total iron capacity, and patient comorbidities were obtained from patient medical records. The comorbidities were determined through provider notes, and evidence of applicable testing. Results 14.89% of patients were found to have atrial fibrillation (n = 14), 30.85% of patients were found to have peripheral arterial disease (n = 29), and 6.38% of patients were found to have both peripheral arterial disease and atrial fibrillation (n = 6). When compared to patients with only ESRD, patients with ESRD and PAD showed elevated levels of D-Dimer (p = .0314) and nitrotyrosine (p = .0330). When compared to patients with only ESRD, patients with atrial fibrillation showed elevated levels of D-Dimer (p = .0372), nitrotyrosine (p = .0322), and tPA (p = .0198). Conclusion When compared to patients with just ESRD, patients with concomitant PAD had elevated levels of Nitrotyrosine and D-dimer; while patients with concomitant Afib had elevated levels of nitrotyrosine, D-dimer, as well as tPA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1938-2723 10760296 |
| العلاقة: | https://doaj.org/toc/1938-2723Test |
| DOI: | 10.1177/10760296211072820 |
| الوصول الحر: | https://doaj.org/article/e9a33cb79c1d438d8ed20d220d91c08dTest |
| رقم الانضمام: | edsdoj.9a33cb79c1d438d8ed20d220d91c08d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19382723 10760296 |
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| DOI: | 10.1177/10760296211072820 |