دورية أكاديمية
Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective
| العنوان: | Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective |
|---|---|
| المؤلفون: | Yingjing Xia, Vida Rebello, Stefanie C. Bodison, Deborah Jonker, Babette Steigelmann, Kirsten A. Donald, Weslin Charles, Dan J. Stein, Jonathan Ipser, Hedyeh Ahmadi, Eric Kan, Elizabeth R. Sowell, Katherine L. Narr, Shantanu H. Joshi, Hein J. Odendaal, Kristina A. Uban |
| المصدر: | Frontiers in Integrative Neuroscience, Vol 17 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | socioeconomic resources, prenatal substance exposure, neurodevelopment, adverse childhood experiences, prenatal alcohol exposure, prenatal tobacco exposure, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | BackgroundAlcohol and tobacco are known teratogens. Historically, more severe prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) have been examined as the principal predictor of neurodevelopmental alterations, with little incorporation of lower doses or ecological contextual factors that can also impact neurodevelopment, such as socioeconomic resources (SER) or adverse childhood experiences (ACEs). Here, a novel analytical approach informed by a socio-ecological perspective was used to examine the associations between SER, PAE and/or PTE, and ACEs, and their effects on neurodevelopment.MethodsN = 313 mother-child dyads were recruited from a prospective birth cohort with maternal report of PAE and PTE, and cross-sectional structural brain neuroimaging of child acquired via 3T scanner at ages 8–11 years. In utero SER was measured by maternal education, household income, and home utility availability. The child’s ACEs were measured by self-report assisted by the researcher. PAE was grouped into early exposure (=12 weeks), and no exposure controls. PTE was grouped into exposed and non-exposed controls.ResultsGreater access to SER during pregnancy was associated with fewer ACEs (maternal education: β = −0.293,p = 0.01; phone access: β = −0.968,p = 0.05). PTE partially mediated the association between SER and ACEs, where greater SER reduced the likelihood of PTE, which was positively associated with ACEs (β = 1.110,p = 0.01). SER was associated with alterations in superior frontal (β = −1336.036, q = 0.046), lateral orbitofrontal (β = −513.865, q = 0.046), caudal anterior cingulate volumes (β = −222.982, q = 0.046), with access to phone negatively associated with all three brain volumes. Access to water was positively associated with superior frontal volume (β=1569.527, q = 0.013). PTE was associated with smaller volumes of lateral orbitofrontal (β = −331.000, q = 0.033) and nucleus accumbens regions (β = −34.800, q = 0.033).ConclusionResearch on neurodevelopment following community-levels of PAE and PTE should more regularly consider the ecological context to accelerate understanding of teratogenic outcomes. Further research is needed to replicate this novel conceptual approach with varying PAE and PTE patterns, to disentangle the interplay between dose, community-level and individual-level risk factors on neurodevelopment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-5145 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fnint.2023.1104788/fullTest; https://doaj.org/toc/1662-5145Test |
| DOI: | 10.3389/fnint.2023.1104788 |
| الوصول الحر: | https://doaj.org/article/3460c67ba11a469ca93fee1ab5cec907Test |
| رقم الانضمام: | edsdoj.3460c67ba11a469ca93fee1ab5cec907 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16625145 |
|---|---|
| DOI: | 10.3389/fnint.2023.1104788 |