A New Implantable Closed-Loop Clinical Neural Interface
| العنوان: | A New Implantable Closed-Loop Clinical Neural Interface |
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| المؤلفون: | Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L. F. Janssen, Alberto Priori, Sara Marceglia |
| المساهمون: | Arlotti, M., Colombo, M., Bonfanti, A., Mandat, T., Lanotte, M. M., Pirola, E., Borellini, L., Rampini, P., Eleopra, R., Rinaldo, S., Romito, L., Janssen, M. L. F., Priori, A., Marceglia, S., Klinische Neurowetenschappen, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: MHeNs - R3 - Neuroscience |
| المصدر: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience Frontiers in Neuroscience, 15:763235. Frontiers Media S.A. |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | deep brain stimulation, neuromodulation, closed-loop, local field potential (LFP), Parkinson’s disease, neural interface, implantable device, closed-loop, ARTIFACT, General Neuroscience, Parkinson's disease, LEVODOPA, DBS, Neurosciences. Biological psychiatry. Neuropsychiatry, DEVICE, LOCAL-FIELD POTENTIALS, deep brain stimulation, local field potential (LFP), PERSPECTIVES, neuromodulation, implantable device, Parkinson’s disease, OSCILLATIONS, neural interface, Deep Brain Stimulation Neuromodulation Closed-loop Parkinson's disease Local field potential Neural interface Implantable device, Neuroscience, Original Research, RC321-571, DEEP BRAIN-STIMULATION, SUPPRESSION |
| الوصف: | Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson’s disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson’s disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place. |
| اللغة: | English |
| تدمد: | 1662-453X 1662-4548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8398232f8102902c788a3754ff11caTest https://cris.maastrichtuniversity.nl/en/publications/ede2c601-bea0-4f60-b043-8273433218d4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb8398232f8102902c788a3754ff11ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1662453X 16624548 |
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