دورية أكاديمية
Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
| العنوان: | Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus |
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| المؤلفون: | Jiménez-Alonso Juan, García-Hernández Francisco J, Garcia-Portales Rosa, de Ramón Enrique, Callejas José L, Sabio José M, Sánchez Elena, González-Escribano Ma Francisca, Martín Javier, Koeleman Bobby P |
| المصدر: | BMC Medical Genetics, Vol 7, Iss 1, p 48 (2006) |
| بيانات النشر: | BMC |
| سنة النشر: | 2006 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Background Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8 , IL-1α , and MCP-1 for systemic lupus erythematosus. Methods The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8 , IL-1α , and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay. Results No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the RANTES , IL-8 , IL-1α , and MCP-1 polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found. Conclusion These results suggest that the tested functional variation of RANTES , IL-8, IL-1α , and MCP-1 genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2350 |
| العلاقة: | http://www.biomedcentral.com/1471-2350/7/48Test; https://doaj.org/toc/1471-2350Test; https://doaj.org/article/f269459ae4c34f3c8a782cd653a14181Test |
| DOI: | 10.1186/1471-2350-7-48 |
| الإتاحة: | https://doi.org/10.1186/1471-2350-7-48Test https://doaj.org/article/f269459ae4c34f3c8a782cd653a14181Test |
| رقم الانضمام: | edsbas.4A150244 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712350 |
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| DOI: | 10.1186/1471-2350-7-48 |