التفاصيل البيبلوغرافية
| العنوان: |
Prevalence and mortality associations of interstitial lung abnormalities in rheumatoid arthritis within a multicentre prospective cohort of smokers. |
| المؤلفون: |
McDermott, Gregory C1,2, Hayashi, Keigo1, Yoshida, Kazuki1,2, Moll, Matthew2,3,4,5, Cho, Michael H2,3,4, Doyle, Tracy J2,3, Kinney, Gregory L6, Dellaripa, Paul F1,2, Putman, Rachel K2,3, Estepar, Raul San Jose2,7, Hata, Akinori8, Hino, Takuya9, Hida, Tomoyuki9, Yanagawa, Masahiro8, Nishino, Mizuki7, Washko, George2,3, Regan, Elizabeth A10, Hatabu, Hiroto2,7, Hunninghake, Gary M2,3, Silverman, Edwin K2,3,4 |
| المصدر: |
Rheumatology. 2023 Special Issue, Vol. 62, pSI286-SI295. 10p. |
| مصطلحات موضوعية: |
*RESEARCH, *CONFIDENCE intervals, *INTERSTITIAL lung diseases, *RHEUMATOID arthritis, *RESEARCH funding, *DESCRIPTIVE statistics, *TOBACCO products, *SMOKING, *COMPUTED tomography, *ODDS ratio, *DATA analysis software, *LONGITUDINAL method, *DISEASE complications |
| مستخلص: |
Objective To investigate the prevalence and mortality impact of interstitial lung abnormalities (ILAs) in RA and non-RA comparators. Methods We analysed associations between ILAs, RA, and mortality in COPDGene, a multicentre prospective cohort study of current and past smokers, excluding known interstitial lung disease (ILD) or bronchiectasis. All participants had research chest high-resolution CT (HRCT) reviewed by a sequential reading method to classify ILA as present, indeterminate or absent. RA cases were identified by self-report RA and DMARD use; non-RA comparators had neither an RA diagnosis nor used DMARDs. We examined the association and mortality risk of RA and ILA using multivariable logistic regression and Cox regression. Results We identified 83 RA cases and 8725 non-RA comparators with HRCT performed for research purposes. ILA prevalence was 16.9% in RA cases and 5.0% in non-RA comparators. After adjusting for potential confounders, including genetics, current/past smoking and other lifestyle factors, ILAs were more common among those with RA compared with non-RA [odds ratio 4.76 (95% CI 2.54, 8.92)]. RA with ILAs or indeterminate for ILAs was associated with higher all-cause mortality compared with non-RA without ILAs [hazard ratio (HR) 3.16 (95% CI 2.11, 4.74)] and RA cases without ILA [HR 3.02 (95% CI 1.36, 6.75)]. Conclusions In this cohort of smokers, RA was associated with ILAs and this persisted after adjustment for current/past smoking and genetic/lifestyle risk factors. RA with ILAs in smokers had a 3-fold increased all-cause mortality, emphasizing the importance of further screening and treatment strategies for preclinical ILD in RA. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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