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1دورية أكاديمية
المؤلفون: F Aghaei, M Mohsenzadeh, F Nameni, F Feizollahi
المصدر: Armaghane Danesh Bimonthly Journal, Vol 23, Iss 6, Pp 709-721 (2019)
مصطلحات موضوعية: HIIT, Retinol Binding Protein 4 (RBP4), AMP-activated protein kinase(AMPK), diabetes, Medicine (General), R5-920
الوصف: Background & aim: The positive effects of High Intensity Interval Training (HIIT) on reinforcement of healthy muscle tissue metabolism pathways have been long proven. One of the side effects of diabetes is the impairment of glucose metabolism and muscle fat. Therefore, the aim of the present study was to investigate the effect of HIIT on Retinol Binding Protein 4 (RBP) and AMP-activated protein kinase (AMPK) gene expression in skeletal muscle of rats with type II diabetes. Methods: Sixty male Wistar rats (age: 8 weeks, weighing 250 ± 20 g) were randomly divided into 5 groups (n = 12): basal, healthy control, diabetes, HIIT, diabetes and exercise group. Before the starting of the training program, all groups except the basal group and control and exercise were injected with nicotinamide - streptozotocin (STZ) by peritoneal injection to induce diabetic model. The training rats were treated for 8 weeks, 5 days a week, with an intensity of 80 to 85% of maximum speed to HIIT exercises. 48 hours after the last training session, after anesthesia, soleus muscle was removed and mRNA RBP4 and mRNA AMPK were measured. Data were analyzed by ANOVA and post hoc Tukey test (P
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: F Aghaei Borashan
المصدر: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 2, Iss 3 (2012)
مصطلحات موضوعية: Medicine (General), R5-920
الوصف: Background and ObjectivesRheumatoid arthritis (RA) is a chronic inflammatory disease which is characterized by joint swelling, and synovial inflammation. C reactive protein (CRP) and ceruloplasmin (CP) are identified as important biomarkers of RA and various inflammatory diseases. Curcumin, a widely used yellow color spice is the most active component of Curcuma longa L (Turmeric). Curcumin contains potent anti-inflammatory and antioxidant properties. The goal of this study is evaluation of the anti-inflammatory effect of curcumin on arthritic palm of rats and levels of the CRP and CP in the blood samples of arthritis induced male albino Wistar rats. Methods Arthritis was induced by subcutaneous injection of Freund’s Complete Adjuvant (FCA) into the palm of right rear foot of 8 different male albino Wistar rats. The rats were randomly divided into five groups after the injection. These groups were as follow:Group Ι, control normal ratsGroup II, carrier arthritic ratsGroup III, arthritic rats which were given 30mg/ kg of curcumin orally seven days prior to FCA injectionGroup IV, arthritic rats treated with 30mg/kg of curcuminGroup V, arthritic rats treated with 3 mg/kg of indomethacin.All the groups except group III received oral treatment with curcumin seven days after FCA injection and the treatment was continued fourteen days thereafter. The rear foot thicknesses of all the rats were measured on days 1, 5, 10, 15, 20 after FCA injection. The rats were destroyed after 20th day and their blood samples were collected. ResultsThe results of this study indicate that curcumin significantly decreases swelling of the rats rear foot (pOne-way variance analysis by ANOVA program and post test analysis by Tukey were used for analysis of the collected data. ConclusionEvaluation of the results of this experiment supports the anti-inflammatory, and possibly anti-arthritic properties of curcumin in the treatment of RA.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: F. Aghaei Borashan, M. Ilkhanipoor, M. Hashemi, F. Farrokhi
المصدر: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 2, Iss 3, Pp 9-16 (2008)
مصطلحات موضوعية: Rheumatoid Arthritis (RA), Freund’s Complete Adjuvant, Ceruloplasmin, C- Reactive Protein, Medicine (General), R5-920
الوصف: Background and ObjectivesRheumatoid arthritis (RA) is a chronic inflammatory disease which is characterized by joint swelling, and synovial inflammation. C reactive protein (CRP) and ceruloplasmin (CP) are identified as important biomarkers of RA and various inflammatory diseases. Curcumin, a widely used yellow color spice is the most active component of Curcuma longa L (Turmeric). Curcumin contains potent anti-inflammatory and antioxidant properties. The goal of this study is evaluation of the anti-inflammatory effect of curcumin on arthritic palm of rats and levels of the CRP and CP in the blood samples of arthritis induced male albino Wistar rats.Methods Arthritis was induced by subcutaneous injection of Freund’s Complete Adjuvant (FCA) into the palm of right rear foot of 8 different male albino Wistar rats. The rats were randomly divided into five groups after the injection. These groups were as follow: Group Ι, control normal rats Group II, carrier arthritic rats Group III, arthritic rats which were given 30mg/ kg of curcumin orally seven days prior to FCA injectionGroup IV, arthritic rats treated with 30mg/kg of curcumin Group V, arthritic rats treated with 3 mg/kg of indomethacin.All the groups except group III received oral treatment with curcumin seven days after FCA injection and the treatment was continued fourteen days thereafter. The rear foot thicknesses of all the rats were measured on days 1, 5, 10, 15, 20 after FCA injection. The rats were destroyed after 20th day and their blood samples were collected.ResultsThe results of this study indicate that curcumin significantly decreases swelling of the rats rear foot (p
وصف الملف: electronic resource
